Bibliometric analysis of research trends and emerging insights of osteoarthritis and chondrocyte hypertrophy

Frontiers in Surgery, Journal Year: 2025, Volume and Issue: 12

Published: April 10, 2025

This study aims to systematically analyze the intersection of OA and chondrocyte hypertrophy using bibliometric methods, providing an quantitative comprehensive overview current research status emerging trends in this field. Relevant publications were retrieved from Web Science Core Collection database search query TS = ("chondrocyte* hypertroph*" OR "hypertrophic chondrocyte*" "cartilage hypertroph*") AND ("osteoarthriti*" "OA" "degenerative arthritis"). Several tools, including Vosviewer, CiteSpace, R package (bibliometrix), Excel 2021, utilized on OA. A total 639 publications, published between 1995 2025, identified. The findings indicate a steady global increase hypertrophy, with increasing number studies being high-impact journals, suggesting promising developmental trajectory. China United States are leading OSTEOARTHRITIS CARTILAGE is identified as core journal area, while ANNALS OF THE RHEUMATIC DISEASES has highest impact factor among top publishing journals. Keyword analysis reveals that hotspots primarily focus stem cells, tissue engineering, cartilage repair, inflammation, oxidative stress, autophagy, apoptosis, senescence, related bioactive factors. elucidates at crucial references for future research. Future should continue these potential therapeutic approaches, key phenotypes, regulatory mechanisms, enhance international cooperation develop more effective strategies treatments

Language: Английский

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Therapeutic potential of CHI3L1 in osteoarthritis: Inhibition of cartilage matrix degradation and inflammation through TLR4-MAPK-STAT1 pathway

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114684 - 114684

Published: April 19, 2025

CHI3L1 has been identified as a protein expressed in various tissues and tumor tissues, playing critical roles diverse physiological pathological processes such inflammation, oxidative stress, cell death, immune regulation. Previous studies have indicated that the elevated levels synovial fluid serum of osteoarthritis patients may serve biomarker for osteoarthritis. However, mechanisms by which affects chondrocytes significance its upregulated expression remain to be fully elucidated. This study aims investigate effects on elucidate molecular mechanisms. Interleukin-1 beta (IL-1β) was utilized vitro induce an inflammatory injury model chondrocytes. The destabilization medial meniscus (DMM) surgery employed establish mouse vivo. Experimental techniques, including Western blot, RT-qPCR, immunofluorescence, transcriptome sequencing, co-immunoprecipitation, were applied Microcomputed tomography (micro-CT), X-ray imaging, IHC used evaluate impact knee joint mice. In experiments demonstrated enhanced matrix synthesis markers, suppressed degradation indicators, reduced factors vivo showed intra-articular overexpression via rAAV-Chi3l1 alleviated cartilage degeneration inflammation murine model. Mechanistically, integrated transcriptomic profiling functional assays revealed interacts with TLR4 attenuate MAPK phosphorylation, thereby inhibiting STAT1 phosphorylation nuclear translocation. is alleviates through TLR4-MAPK-STAT1 pathway, progression These findings indicate cytokine protective represent promising therapeutic target alleviating objective this further underlying exerts influence study, it proposed maintains homeostasis activation signaling pathway. We established role maintaining homeostasis, potential receptors pathways associated CHI3L1, elucidated action. osteoarthritic tissue not yet investigated. Further research needed secreted

Language: Английский

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Therapeutic application of regulatory T cell in osteoarthritis

Journal of Microbiology Immunology and Infection, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Regulatory T cells (Tregs) are the specific cell population that suppress inflammatory immunity. Independent of their inhibitory activities, Tregs exhibit unique capacity to repair tissue damage. Rapid progresses made in processing and engineering for clinical applications. have been used treatment autoimmune diseases, transplantation rejection graft-versus-host disease. Osteoarthritis is one major diseases affect at least 600 million people worldwide. characterized by physical erosion cartilage, accompanied with chronic low-grade inflammation. possess abilities increase osteoclast differentiation bone resorption, damage, mass. therefore candidate therapeutics osteoarthritis both inflammation resolution repairing. In this review, we will summarize recent development using immunotherapy, potential osteoarthritis.

Language: Английский

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RNA-binding protein HuR interacts with UFM1 mRNA to ameliorate chondrocyte inflammation, apoptosis and extracellular matrix degradation

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 28, 2025

Language: Английский

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Are Osteoarthritis Inflammation and Its Related Sensorimotor Interactions Both Noteworthy and Modifiable Key Players?

Published: May 22, 2025

Joints are sensitive structures whose qualitative and quantitative components depend not only on the harmonious interactions of hormones, enzymes, vitamins, minerals protein, but also stresses put upon them by function as well their intrinsic extrinsic neuromotor environments, activity integrity. This paper reviews some recent pathological insights regarding synovial joint’s lining its immune cellular responses that indicate when traumatized may evoke a possible unstoppable cascade inflammation cartilage destruction unless abated in timely way. One essential movement correlate especially fail to limit spread osteoarthritis oftentimes severe repercussions, namely muscle dysfunction is specifically discussed. Based what known we argue favor untapped utility efforts reverse or mitigate post traumatic arthritis, face persistent mechanical impacts.

Language: Английский

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Protective Effects of Vitamin D on Proteoglycans of Human Articular Chondrocytes through TGF-β1 Signaling

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2991 - 2991

Published: Sept. 4, 2024

The extracellular matrix of cartilage primarily constitutes collagen and aggrecan. Cartilage degradation starts with aggrecan loss in osteoarthritis (OA). Vitamin D (VD) plays an essential role several inflammation-related diseases can protect the during OA. present study focused on VD turnover human articular chondrocytes treated tumor necrosis factor α (TNF-α) possible mechanism. Treatment different doses periods intervention TNF-α TGF-β1 receptor (TGFβR1) inhibitor SB525334 were investigated. viability secretion measured. expression intracellular TGFβR1 was examined. Transcriptional translational levels related metabolic factors analyzed. results showed that markedly reduced viability, expressions chondrocytes, increased disintegrin metalloproteinase thrombospondin motifs. alterations partially inhibited by treatment. Furthermore, effects blocked TNF-α-treated cells. may prevent proteoglycan due to via signaling chondrocytes.

Language: Английский

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Controlled Stimulus-Responsive Delivery Systems for Osteoarthritis Treatment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11799 - 11799

Published: Nov. 2, 2024

Osteoarthritis (OA), a common and disabling degenerative joint disease, affects millions of people worldwide imposes considerable burden on patients society due to its high prevalence economic costs. The pathogenesis OA is closely related the progressive degradation articular cartilage accompany inflammation; however, itself cannot heal modulate inflammation lack nerves, blood vessels, lymph-vessels. Therefore, reliable effective methods treat remain highly desired. Local administration drugs or bioactive materials by intra-articular injection delivery system represents promising approach OA, especially considering prolonged retention, chondrocytes targeting, stimuli-responsive release achieve precision therapy. This article summarizes discusses advances in currently used systems (nanoparticle, hydrogel, liposome, microsphere) then focuses their applications treatment from perspective endogenous stimulus (redox reactions, pH, enzymes, temperature) exogenous (near-infrared, magnetic, ultrasound)-responsive release. Finally, challenges potential future directions for development nano-delivery are summarized.

Language: Английский

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Relationship between systemic immune-inflammation index and osteoarthritis: a cross-sectional study from the NHANES 2005–2018

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 14, 2024

Objective The study aimed to explore the relationship between systemic inflammatory response index (SIRI) levels and osteoarthritis (OA) using cross-sectional data from National Health Nutrition Examination Survey (NHANES) database 2005 2018. Methods Using NHANES 2018, we included 11,381 participants divided into OA ( n = 1,437) non-OA 9,944) groups. Weighted multivariable regression models subgroup analyses were employed investigate SIRI OA. Additionally, restricted cubic spline used nonlinear relationships. Results This enrolled aged ≥20 years, including 1,437 (14%) with analysis in fully adjusted Model 3 indicated a correlation higher of (log 2 -transformed) an increased risk (odds ratio: 1.150; 95% confidence interval: 1.000–1.323, p < 0.05). Interaction tests showed that variables did not significantly affect this for interaction all >0.05). model revealed log risk, threshold effect showing 4.757 as critical value SIRI. <4.757 almost unchanged whereas >4.757 rapidly increasing risk. Conclusion positive 4.757, holds clinical practical applications. our indicates is novel, clinically valuable, convenient biomarker can be predict adults.

Language: Английский

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Association between sarcopenic obesity and osteoarthritis: The potential mediating role of insulin resistance

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 197, P. 112611 - 112611

Published: Oct. 21, 2024

Sarcopenic obesity (SO) and osteoarthritis (OA) are highly prevalent musculoskeletal conditions that significantly impair health-related quality of life.

Language: Английский

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Association between systemic immune inflammation index and osteoarthritis in US adults: a cross-sectional study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 17, 2024

Abstract Background The relationship between systemic immune inflammation index (SII) and the osteoarthritis (OA) has not been well established. This study aimed to investigate associations SII OA risk using data from National Health Nutrition Examination Survey (NHANES) 2005–2016. Methods A cross-sectional was conducted participants in NHANES is calculated as platelet count × neutrophil count/lymphocyte count. Multivariable logistic regression models were used explore link osteoporosis, adjusting for potential confounders. Results total of 18,459 included, which 1130 reported having OA. After confounders, an inverse association observed (OR = 1.27; 95% CI 1.07–1.51, p 0.006). Moreover, we also identify that 515.56 optimal cut-off value, indicating when value exceeds increases rapidly. Conclusions In this large, nationally representative sample U.S. adults, higher negatively associated with Further prospective studies are needed confirm these findings elucidate underlying mechanisms.

Language: Английский

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