Cardiac Magnetic Resonance Guidance for the Pathogenetic Definition of Cardiomyopathies
Current Cardiology Reports,
Journal Year:
2025,
Volume and Issue:
27(1)
Published: April 16, 2025
Abstract
Purpose
of
Review
Pathogenetics
is
the
study
genetics
in
disease
pathogenesis.
Many
abnormal
gene
alleles
have
been
identified
cardiomyopathies,
but
their
clinical
utility
remains
limited.
This
review
aims
to
examine
integration
cardiac
MRI
(CMR)
with
genetic
data
enhance
early
detection,
prognostication,
and
treatment
strategies
for
cardiomyopathies.
Recent
Findings
CMR
gold
standard
imaging
modality
cardiomyopathy
evaluation,
capable
detecting
subtle
structural
functional
changes
throughout
course.
When
applied
patients
mutations,
or
without
phenotypic
expression,
aids
diagnosis
risk
stratification.
Cardiomyopathies
can
be
categorized
into
at
least
seven
groups
based
on
morphology,
function,
associations:
(1)
Dilated
(DCM),
(2)
Hypertrophic
(HCM),
(3)
Restrictive
cardiomyopathy,
including
transthyretin
amyloidosis
(ATTR-CM),
iron
overload,
Anderson-Fabry
disease,
(4)
Arrhythmogenic
(ACM),
(5)
Non-dilated
left
ventricular
(NDLVC),
(6)
Peripartum
(7)
Muscular
dystrophy-related
cardiomyopathy.
We
described
noncompaction
(LVNC)
as
a
morphological
trait
rather
than
distinct
Emerging
suggest
an
inflammatory
component
DCM
ACM,
potential
therapeutic
implications
immunotherapy.
Advanced
techniques,
such
quantitative
perfusion,
distinguish
cardiomyopathies
from
ischemic
heart
detect
microvascular
dysfunction,
particularly
ATTR-CM
HCM.
Late
gadolinium
enhancement
(LGE)
parametric
mapping
(T1
extracellular
volume
[ECV])
further
diagnosis,
prognostication
response
by
assessing
fibrosis
myocardial
composition.
Summary
The
insights
improves
our
understanding
pathogenesis,
aiding
prognostic
assessment.
Future
research
should
leverage
artificial
intelligence
(AI)
analyze
radiomic
features,
perfusion
data,
establish
comprehensive
pathogenetic
framework.
approach
could
refine
classification,
identify
novel
targets,
advance
precision
medicine
management.
Language: Английский
Risk Stratification of Left Ventricle Hypertrabeculation Versus Non‐Compaction Cardiomyopathy Using Echocardiography, Magnetic Resonance Imaging, and Cardiac Computed Tomography
Echocardiography,
Journal Year:
2025,
Volume and Issue:
42(5)
Published: May 1, 2025
Non-compaction
cardiomyopathy
(NCCM)
is
a
rare,
congenital
form
of
characterized
by
excessive
trabeculations
in
the
left
ventricle
myocardium.
NCCM
often
an
underdiagnosed
heart
condition
abnormal
myocardial
trabeculations,
which
can
lead
to
wide
range
clinical
outcomes,
from
asymptomatic
cases
severe
failure
and
arrhythmias.
It
diagnosed
using
imaging
techniques
like
echocardiography,
cardiac
magnetic
resonance
(CMR),
computed
tomography
(CT),
help
assess
heart's
structure
function.
Although
echocardiography
remains
key
tool,
CMR
gold
standard
for
diagnosis,
structural
functional
assessment,
accurate
trabecular
quantification,
detects
fibrosis
with
late
gadolinium
enhancement,
superior
risk
stratification
sudden
death.
CT
has
gained
importance
diagnosing
NCCM,
especially
ruling
out
coronary
artery
disease
evaluating
complications
such
as
thrombus.
Accurate
crucial
identifying
high-risk
patients
providing
timely
interventions.
This
review
examined
contributions
CMR,
assessing
severity,
guiding
treatment
decisions.
We
highlighted
strengths
limitations
each
modality,
discussing
their
ability
detect
abnormalities,
evaluate
function,
identify
or
other
changes.
also
emphasized
integrating
findings
genetic
data
enhance
patient
management
outcomes.
Finally,
we
explored
potential
future
applications
artificial
intelligence
improving
diagnostic
accuracy
refining
assessment
NCCM.
Language: Английский