Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 802 - 802

Published: June 14, 2024

This comprehensive review consolidates insights from two sources to emphasize the transformative impact of scaffold-based drug delivery systems in revolutionizing oral cancer therapy. By focusing on their core abilities facilitate targeted and localized administration, these enhance therapeutic outcomes significantly. Scaffolds, notably those coated with anti-cancer agents such as cisplatin paclitaxel, have proven effective inhibiting cell proliferation, establishing a promising avenue for site-specific delivery. The application synthetic scaffolds, including Poly Ethylene Glycol (PEG) poly(lactic-co-glycolic acid) (PLGA), natural materials, like collagen or silk, 3D has been pivotal controlled release agents, executing diverse strategies. A key advancement this field is advent smart scaffolds designed sequential therapy, which strive refine systems, minimizing surgical interventions, accentuating significance management. These encompassing local drug-coated other platforms, hold potential transform treatment through precise yielding improved patient outcomes. Local via can mitigate systemic side effects typically associated chemotherapy, nausea, alopecia, infections, gastrointestinal issues. Post-drug release, foster conducive environment non-cancerous growth, adhering demonstrating restorative potential. Strategies therapy span injectable self-assembling peptide hydrogels, nanocarriers, dual drug-loaded nanofibrous scaffolds. ensure prolonged synergistic effects, tunable targeting, enhancing efficiency while reducing exposure. Smart capable transitioning cell-friendly surfaces, enabling combinatorial promise revolutionize by delivering interventions optimized In essence, varied forms functionalities, are reshaping They target efficiency, diminish present avenues personalization. Challenges fabrication intricacy, biocompatibility, scalability call additional research. Nonetheless, perspective optimistic, ongoing advancements aim surmount current limitations fully leverage

Language: Английский

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Improving Cancer Therapy: Design, Synthesis, and Evaluation of Carboplatin-Based Nanoliposomes against Breast Cancer Cell Lines

Asian Pacific Journal of Cancer Biology, Journal Year: 2024, Volume and Issue: 9(2), P. 121 - 127

Published: April 22, 2024

Objective: Cancer poses a significant challenge to modern medicine, with breast carcinoma being one of the most prevalent forms disease. Carboplatin is commonly used chemotherapy drug for treating cancer, but its efficacy can be limited due poor water solubility and associated side effects. This study intended enhance therapeutic potency carboplatin by encapsulating it within liposomal nanocarriers. Methods: We fabricated nanoscale liposomes loaded via technique called reverse phase evaporation, examined their physical attributes. also studied toxicity these nanoliposomes on MDA-MB 231 cancer cells. Results: Our findings indicated that nanoparticles possessed negative zeta potential -18.2 mV an average size 278 nm. The loading level was 2.2%, while efficiency encapsulation reached 58.5%. Of note, cytotoxicity in nanoliposomal form markedly more potent against cell line than free (p-value less 0.05). Conclusion: suggest carboplatin-loaded nanocarriers could potentially serve as advanced chemotherapeutic approach treatment offering enhanced reduced effects compared conventional therapy. Further research warranted explore this novel delivery system’s benefits fully.

Language: Английский

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Environmental Determinants of Oral Cancer Development: An Overview

Asian Pacific Journal of Environment and Cancer, Journal Year: 2024, Volume and Issue: 7(1), P. 103 - 111

Published: May 29, 2024

Overview: This review article delves into the influence of environmental factors on onset oral cancer. It examines crucial part played by air pollution, occupational exposure and sun in initiation Methods: For this extensive literature survey, we examined relevant publications centered causes cancer, taking account case-control research appraisals. Our selection consisted works chosen for alignment with our topic areas, robust methodologies, recent publishing timelines. Results: investigation revealed that are significant contributing to development When present together, they pose an even greater risk. In other words, combination these three elements significantly increases likelihood cancer occurrence. is take measures reduce exposure, pollution UV rays from mitigate Conclusion: The emergence arises intricate relationship encompassing hereditary ecological variables. Efforts devoted prevention ought prioritize diminishing direct established threats, refining general wellbeing guidelines, informing individuals prone elevated risk circumstances. Expanded exploration stays imperative illuminating contributions made obscured facets, notably plus devising groundbreaking precautionary tactics.

Language: Английский

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Studying the Characteristics of Curcumin-Loaded Liposomal Nanoparticles

Asian Pacific Journal of Cancer Biology, Journal Year: 2024, Volume and Issue: 9(2), P. 183 - 189

Published: May 29, 2024

Overview: In this study, the physical and chemical properties of curcumin are extensively examined when it is incorporated into liposome nanoparticles, to enhance its therapeutic potency bioavailability. Curcumin, a plant-derived polyphenol, has garnered attention for anti-inflammatory, antioxidant, anti-cancer activities. However, clinical utility hindered by several limitations, including poor water solubility, inadequate absorption, rapid metabolism. By leveraging potential nanoparticles improve drug delivery efficacy, research aims overcome these obstacles unlock full curcumin. Methods: Curcumin-loaded (CLLNs) were fabricated employing thin-film hydration method, after sonication. The physicochemical attributes CLLNs subsequently characterized, encompassing particle size zeta assessment utilizing dynamic light scattering (DLS), encapsulation efficiency (EE%) loading (DLE%) determination through high-performance liquid chromatography (HPLC), investigation in vitro release patterns simulated biological fluids. Results: optimized study had mean diameter less than 250 nm negative surface charge, implying good stability cellular uptake. both found be high, indicating that was effectively loaded liposomes. testing showed sustained pattern from CLLNs. Conclusion: offered important observations about advantageous features curcumin-loaded highlighting their as cutting-edge system demonstrated have high efficiencies, well controlled improved stability, which suggests ability benefits These findings set stage future vivo trials fully investigate medical applications.

Language: Английский

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