High-Altitude Medicinal Plants as Promising Source of Phytochemical Antioxidants to Combat Lifestyle-Associated Oxidative Stress-Induced Disorders

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 975 - 975

Published: July 23, 2024

Oxidative stress, driven by reactive oxygen, nitrogen, and sulphur species (ROS, RNS, RSS), poses a significant threat to cellular integrity human health. Generated during mitochondrial respiration, inflammation, UV exposure pollution, these damage cells contribute pathologies like cardiovascular issues, neurodegeneration, cancer, metabolic syndromes. Lifestyle factors exert substantial influence on oxidative stress levels, with mitochondria emerging as pivotal players in ROS generation equilibrium. Phytochemicals, abundant plants, such carotenoids, ascorbic acid, tocopherols polyphenols, offer diverse antioxidant mechanisms. They scavenge free radicals, chelate metal ions, modulate signalling pathways mitigate damage. Furthermore, plants thriving high-altitude regions are adapted extreme conditions, synthesize secondary metabolites, flavonoids phenolic compounds bulk quantities, which act form robust defence against including radiation temperature fluctuations. These promising sources for drug development, offering innovative strategies manage stress-related ailments enhance Understanding harnessing the potential of phytochemicals from represent crucial steps combating stress-induced disorders promoting overall wellbeing. This study offers comprehensive summary production physio-pathological aspects lifestyle-induced explores antioxidants. Additionally, it presents an appraisal medicinal antioxidants, highlighting their development creation therapeutic approaches.

Language: Английский

---

A comprehensive review of anti-cancer mechanisms of polyphenol honokiol and nano carrier-based approaches to enhance its therapeutic potential

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

---

Ferulic Acid: A Comprehensive Review

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Ferulic acid (FA), a phenolic compound abundant in the cell walls of seeds, leaves, and roots various fruits, vegetables, cereals, grains, is renowned for its wide range biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer properties. Despite therapeutic potential, clinical application FA hindered by challenges such as poor water solubility, limited bioavailability, rapid metabolism, instability under physiological conditions. To address these issues, nanotechnology has emerged transformative approach, enhancing FA's pharmacokinetic profile. Various nanoparticle-based systems, polymer-based lipid-based nanoparticles, have been developed to encapsulate FA. These systems demonstrated significant improvements stability, with studies showing enhanced antioxidant activity controlled release profiles. Further, surface engineering nanoparticles provides targeted drug/phytochemical delivery potential. The drugs/phytochemicals significantly enhances efficacy minimizes systemic side effects. This review explores potential FA, limitations application, advancements that are paving way effective use.

Language: Английский

---

Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 201 - 218

Published: Jan. 1, 2025

Purpose: Phytosome technology, an advanced lipid-based delivery system, offers a promising solution for enhancing the bioavailability and therapeutic efficacy of secondary metabolites, particularly in cancer treatment. These such as flavonoids, terpenoids, alkaloids, possess significant anticancer potential but are often limited by poor solubility low absorption. This review aims to investigate how phytosome encapsulation improves pharmacokinetic profiles effectiveness these bioactive compounds. Patients Methods: comprehensive is based on analysis recent literature retrieved from PubMed, Scopus, ScienceDirect databases. It focuses findings preclinical vitro studies that examine enhancements provided technology when applied metabolites. Results: Phytosome-encapsulated metabolites exhibit significantly improved solubility, absorption, distribution, cellular uptake compared non-encapsulated forms. enhanced facilitates more effective inhibition pathways, including NF-κB PI3K/AKT, leading increased models. Conclusion: has demonstrated its overcome challenges, resulting safer options highlights phytosome-based formulations novel approach therapy, supporting further development preclinical, vitro, clinical applications. Keywords: phytosome, cancer,

Language: Английский

---

Nanotechnology Assisted Drug Delivery Strategies for Chemotherapy: Recent Advances and Future Prospects

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

In pursuit of the treatment cancer, nanotechnology engineering has emerged as simplest and most effective means, with potential to deliver antitumor chemotherapeutics at targeted site. Employing for drug delivery provides diverse nanosize particles ranging from one a thousand nanometers. Reduced size improves bioavailability by increasing diffusion decreasing efflux rate. These nanocarriers offer an enormous scope modification following chemical biological properties both its disease. Moreover, these nanoformulations assist in targeting pharmaceutically active molecules desired site have gained importance recent years. Their modern use revolutionized action many therapeutic agents. Higher loading efficiency, thermal stability, easy fabrication, low production cost, large-scale industrial draw attention application better platform molecules. Furthermore, interaction nanocarrier technology-assisted agents lowers drug's toxicity dosage, reduces tolerance, enhances concentration neoplasm tissue, thus healthy tissue. Nanotechnology-based medications are being widely explored depicted cancer management vivo vitro systems, leading clinical trials promising results. This review summarizes innovative impact different developed years therapy. Subsequently, it also describes essential findings methodologies their effects on treatment. Compared conventional therapy, nanomedicines can significantly improve effectiveness drugs. Thus, adverse associated tissues decreased, scaled back through enhanced permeability retention effects. Lastly, future insights assisting therapeutics been discussed.

Language: Английский

---

Antibiotic Loaded Phytosomes as a Way to Develop Innovative Lipid Formulations of Polyene Macrolides

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 665 - 665

Published: May 16, 2024

The threat of antibiotic resistance fungal pathogens and the high toxicity most effective drugs, polyene macrolides, force us to look for new ways develop innovative antifungal formulations.

Language: Английский

---

Simultaneous estimation of paclitaxel and bortezomib via LC-MS/MS: pharmaceutical and pharmacokinetic applications

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(24), P. 1995 - 2010

Published: Aug. 8, 2024

This study evaluates the potential of combining paclitaxel (PTX) and bortezomib (BTZ) for breast cancer therapy.

Language: Английский

---