Green Extraction Strategies and Bioactivity of Rheum cordatum Losinsk: Antioxidant, Antimicrobial, and Molecular Docking Insights
Plants,
Journal Year:
2025,
Volume and Issue:
14(7), P. 1071 - 1071
Published: April 1, 2025
This
study
aimed
to
compare
the
efficiency
of
different
green
extraction
methods
for
obtaining
bioactive
compounds
from
roots
Rheum
cordatum
Losinsk
and
evaluate
their
antioxidant
antimicrobial
properties.
The
presence
some
important
phytochemicals
in
extracts
obtained
using
ultrasound-assisted
(UAE),
subcritical
ethanol
(Sbc-EtOH),
supercritical
CO2
(ScCO2)
was
determined
by
LC-MS/MS,
properties
were
examined
against
Staphylococcus
aureus,
Enterococcus
faecalis,
Pseudomonas
aeruginosa,
Escherichia
coli.
goal
determine
optimal
conditions
that
maximize
yield
while
preserving
biological
Different
pressures
(100
bar
400
bar)
tested
UAE
extraction,
solvents
times
Sbc-EtOH
ScCO2
extraction.
Most
53
phenolic
have
been
extracted
method,
either
exclusively
or
highest
amounts.
It
has
observed
more
higher
amounts
at
lower
pressure.
activity
exhibited
extracts.
Additionally,
ScCO2-100
extract
100
showed
strong
activity,
with
a
minimum
inhibitory
concentration
(MIC)
ranging
31.25
250
μg/mL.
Gallic
acid,
epicatechin
gallate,
epigallocatechin
catechin
found
molecular
docking
studies
1QWZ,
2ANQ,
3H77,
6QXS
proteins
revealed
scores
-6.127,
-9.479,
-5.836,
-7.067
kcal/mol,
respectively.
Language: Английский
Novel Vanillin-Derived Schiff Bases: Synthesis, Characterization, Antibacterial Activity, Enzyme inhibition, Antioxidant activity, Anti-Inflammatory Activity on LPS-Induced RAW264.7 Macrophage Cell Line, and In Silico Studies
Journal of Molecular Structure,
Journal Year:
2025,
Volume and Issue:
unknown, P. 142320 - 142320
Published: April 1, 2025
Language: Английский
Boron Compounds as Key Drivers of Innovation: Exploring Their Role in Environmental Remediation, Sustainable Agriculture, Advanced Biomedical Applications, and Green Chemistry
Journal of Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 123688 - 123688
Published: April 1, 2025
Language: Английский
Antioxidant, anti-acetylcholinesterase potentials, ADME estimations and molecular docking studies of green algae extracts
European Journal of Life Sciences,
Journal Year:
2025,
Volume and Issue:
4(1), P. 24 - 35
Published: April 30, 2025
Algae
have
become
the
center
of
attention
due
to
their
strong
antioxidants
and
enzyme-inhibitory
activities.
In
this
study,
green
algae
(Enteromorpha
linza)
extracts
obtained
using
acetone,
hexane
methanol
were
investigated.
antioxidant
properties,
anti-acetylcholinesterase
(AChE)
potential,
ADME
estimations
molecular
docking
analyses
The
best
binding
position
was
by
sirsimaritin,
daidzein,
kaempferol,
morin
myricetin
active
site
acetylcholinesterase
receptor.
Docking
score
values
calculated
as
-10.0,
-10.3,
-9.9,
-9.8
kcal/mol,
respectively.
Experimental
analysis
revealed
that
showed
inhibitory
activity
against
enzyme.
Acetone
extract
good
inhibition
performance
with
IC50
0.0379
mg/ml
0.0414
mg/ml,
value
for
determined
0.997
mg/ml.
When
results
evaluated
in
terms
both
DPPH
ABTS
radical
scavenging
capacities,
it
acetone-based
had
a
higher
capacity
(DPPH:
17.48%,
ABTS:
83.58%)
compared
other
solvents.
general,
examined
can
be
used
source
natural
agents
beneficial
human
health.
Language: Английский