Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 48, P. A1 - A2
Published: Sept. 1, 2024
Language: Английский
Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 50, P. 333 - 353
Published: Jan. 1, 2025
Bone and soft tissues are connected by a complex interface that is crucial for the smooth transfer of mechanical stress. Effective repair this requires bio-scaffolds specifically designed to support regeneration diverse cell types signalling molecules. With advances in micro- nanotechnologies, gradient biomaterial scaffolds have demonstrated significant potential tissue regeneration. This paper reviews structure bone-soft interface, various scaffold types, construction methods. It also discusses recent developments future directions engineering, emphasizing restore natural function interfaces. Overall, provides valuable insights into application offering inspiration biomimetic approaches soft-hard medical engineering. First, emphasis on could significantly impact clinical practices related integration, ultimately improving patient outcomes quality life. Second, it aligns with growing trend potentially inspiring new innovations strategies.
Language: Английский
Citations
1
Orthopedic Research and Reviews, Journal Year: 2025, Volume and Issue: Volume 17, P. 105 - 113
Published: March 1, 2025
Tendon healing after ligament or tendon reconstruction remains a significant challenge. Regenerative tissue engineering, an interdisciplinary field that combines biology, materials science, and offers promising solutions. Recent developments have introduced scaffold designed to enhance the proliferation differentiation of tendon-to-bone cells. These scaffolds possessing three-dimensional composites cells biomaterials, proven effective in facilitating curing post-surgery. The successful development interface is critical factor for early rehabilitation functional recovery. In this mini-review, we present comprehensive update on contemporary strategies synthetic scaffold-based their influence healing. We described compositions, structures features single-layer, multi-layer, gradient with special mechanical properties. examined construction engineering from perspectives biomaterials design strategies, providing evaluation advantages disadvantages associated each approach. Ultimately, review articulates clear research directions aimed at achieving breakthroughs future studies.
Language: Английский
Citations
0
Next research., Journal Year: 2025, Volume and Issue: unknown, P. 100261 - 100261
Published: March 1, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 4, 2025
With an increasing incidence of orthopedic fractures due to the growing aging population, demand for novel bone tissue engineering treatments is rising. Existing biopolymeric scaffolds have hierarchical structure, are biocompatible, and biodegradable, but struggle control pore size interconnectivity, essential features regulate cell alignment mechanobiological signaling. This highlights need design a scaffold with well-defined structure optimized surface properties improve regeneration. To accomplish this, we proposed grid-in-grid manufacturing approach fabricated solvent-free 3D polycaprolactone (PCL) pores using precision extruding deposition (PED) printing technology. The exhibit both global multi-scale local pores. Notably, in vitro cultured human mesenchymal stem cells (hMSCs), controlled induced contact guidance bridging, roughness strands effectively led alignment. study demonstrates that technology can directly manipulate structures migration Furthermore, it could be applied combined connective regeneration, where gradient essential. Our has potential serve as customizable platform advanced applications.
Language: Английский
Citations
0
Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 48, P. A1 - A2
Published: Sept. 1, 2024
Language: Английский
Citations
0