LIPUS activated piezoelectric pPLLA/SrSiO3 composite scaffold promotes osteochondral regeneration through P2RX1 mediated Ca2+ signaling pathway

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123084 - 123084

Published: Jan. 2, 2025

Language: Английский

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A phase-transited lysozyme coating doped with strontium on titanium surface for bone repairing via enhanced osteogenesis and immunomodulatory

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 6, 2025

Titanium is currently recognized as an excellent orthopedic implant material, but it often leads to poor osseointegration of the implant, and prone aseptic loosening leading failure. Therefore, biofunctionalization titanium surfaces needed enhance their immunomodulation properties reduce risk loosening. We concluded that utilization PTL-Sr a direct effective method for fabrication multifunctional implants. In this Study, phase-transited lysozyme (PTL) deposited onto surface (Ti) construct functional coating strontium chloride solution was utilized produce PTL coatings with Sr2+. The characterization strontium-doped (PTL-Sr) tested by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) inductively coupled plasma atomic emission (ICP-AES). A series cell animal experiments were conducted investigate biological functions coatings. indicates successful preparation vitro cellular have demonstrated promotes M2 macrophage polarization reduces inflammatory mediator production while promoting osteogenic differentiation bone merrow mesenchymal stem cells (BMSCs). in vivo subcutaneous implantation model its good immunomodulatory angiogenic properties. promote biomineralization immunomodulation, which suitable applications. Further mechanistic exploration studies using models necessary understanding clinical applicability modified titanium.

Language: Английский

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Mechanisms and Countermeasures for Muscle Atrophy in Microgravity

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2120 - 2120

Published: Dec. 20, 2024

Previous studies have revealed that muscle atrophy emerges as a significant challenge faced by astronauts during prolonged missions in space. A loss mass results weakening of skeletal strength and function, which will not only contribute to decline overall physical performance but also elevate the risk various age-related diseases. Skeletal microgravity environment is thought be associated with changes energy metabolism, protein calcium ion homeostasis, myostatin levels, apoptosis. Modulating some pathways could promising approach mitigating environment. This review serves comprehensive summary research on impact muscle, aim providing insights into its pathogenesis development effective treatments.

Language: Английский

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Addressing musculoskeletal disorders through new treatment strategies

Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 48, P. A1 - A2

Published: Sept. 1, 2024

Language: Английский

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