Inhibition of ERK1/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 51, P. 163 - 175

Published: March 1, 2025

Language: Английский

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Oxidized low-density lipoprotein induced ferroptosis in nucleus pulposus cell contributes to intervertebral disc degeneration via LOX-1/NF-κB/NOX signal

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114455 - 114455

Published: March 20, 2025

Language: Английский

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Redox modulatory role of DJ-1 in Parkinson’s disease

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: March 30, 2025

Language: Английский

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Impact of Pathogenic Mutations on the Refolding Ability and Stability of Human Mitochondrial Phenylalanyl-tRNA Synthetase

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110430 - 110430

Published: April 1, 2025

Language: Английский

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REDOX Imbalance and Oxidative Stress in the Intervertebral Disc: The Effect of Mechanical Stress and Cigarette Smoking on ER Stress and Mitochondrial Dysfunction

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 613 - 613

Published: April 19, 2025

Low back pain is a widespread condition that significantly impacts quality of life, with intervertebral disc degeneration (IDD) being major contributing factor. However, the underlying mechanisms IDD remain poorly understood, necessitating further investigation. Environmental risk factors, such as mechanical stress and cigarette smoke, elevate reactive oxygen species levels from both endogenous exogenous sources, leading to redox imbalance oxidative stress. The endoplasmic reticulum (ER) mitochondria, two key organelles responsible for protein folding energy production, respectively, are particularly vulnerable Under conditions, ER mitochondrial dysfunction occur, resulting in unfolded response activation, impaired biosynthetic processes, disruptions tricarboxylic acid cycle electron transport chain, ultimately compromising metabolism. Prolonged excessive can trigger apoptosis through ER–mitochondrial crosstalk. Given unique microenvironment (IVD)—characterized by hypoxia, glucose starvation, region-specific cellular heterogeneity—the differential effects environmental stressors on distinct IVD cell populations require This review explores potential which factors alter activities, progression, discusses future therapeutic strategies aimed at mitigating degeneration.

Language: Английский

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The BATF2-ATF3 axis exacerbates intervertebral disc degeneration via inducing mitochondrial dysfunction

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114661 - 114661

Published: April 22, 2025

Language: Английский

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Role of oxidative stress in intervertebral disc degeneration: mechanisms, pathogenesis, and therapeutic strategies

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: May 2, 2025

Language: Английский

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Global, regional, and national burdens of low back pain in women of childbearing age from 1990 to 2021: an analysis based on the global burden of disease study 2021

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 7, 2025

Low back pain (LBP) is very common in women of child bearing age (WCBA) and a major burden on individuals society, but studies about it have not been reported. Trend analyses were based data from the Global Burden Disease, Injuries, Risk Factors Study (GBD) 2021. We investigated global trends number prevalence cases, years lived with disability (YLDs), YLDs rate for LBP WCBA. used joint point regression to report average annual changes identify most variable trend. Simultaneously, we further analyzed these by stratifying them region, nation, age. Globally, increased substantially 1990 2021(the prevalence: 39.65%) (the YLDs: 39.53%), whereas WCBA decreased AAPC: -0.1355 [95% CI -0.1419 -0.1288) -0.1365 -0.1427 -0.1302]). Regionally, among medium socio-demographic index region showed an increasing trend(the 0.1291 CI: 0.118 0.1396]) 0.1371 0.1251 0.1499]). Nationally, Thailand Vietnam countries largest increases YLD rates(Thailand: 0.7742 0.7589 0.7904]) (Vietnam: 0.7364 0.7263 0.7468]). In patterns, highest rates found 45–49 group(the 14,412.77 per 100,000 2021 UI: 10,482.27 19,077.3]) 1,639.56 population (95% 1,035.24 2,494.9]). Despite declines LBP, remains high. Age- region-specific prevention healthcare strategies should be optimized meet needs reduce disease.

Language: Английский

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Single-cell RNA sequencing-guided engineering of mitochondrial therapies for intervertebral disc degeneration by regulating mtDNA/SPARC-STING signaling

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 564 - 582

Published: March 1, 2025

Language: Английский

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SHLP6: a novel NLRP3 and Cav1 modulating agent in Cu-induced oxidative stress and neurodegeneration

Frontiers in Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: April 1, 2025

Introduction Copper sulfate exposure induces oxidative stress by triggering excessive reactive oxygen species (ROS) production, leading to inflammatory responses, neuroinflammation, and cellular dysfunction. Small humanin-like peptide-6 (SHLP-6), a mitochondria-derived peptide with anti-aging anti-cancer properties, has not been explored for its protective effects against copper toxicity. This study investigates the antioxidant, anti-inflammatory, neuroprotective potential of SHLP-6 in zebrafish larvae exposed sulfate. Methods Zebrafish were treated at concentrations ranging from 10 50 μg/mL. ROS-scavenging activity was assessed using vitro assays, enzymatic antioxidant markers, lipid peroxidation, nitric oxide levels, acetylcholine esterase (AChE) activity, locomotor behavior evaluated. Additionally, gene expression analysis performed markers. Results Treatment 40 μg/mL significantly reduced malformations, improved heart rate (178 bpm), increased survival rates (85%) larvae. The highest ROS inhibition observed 58.7% 74.3%, while enzyme enhanced, superoxide dismutase (68.3 U/mg), catalase (82.40 glutathione (79.3 U/mg). Lipid peroxidation levels decreased 3.86 3.41 U/mg, respectively. AChE (78.3 U/mg) (43.53 m distance travelled). Discussion upregulated TNF-α (2.16-fold), NLRP3 (1.78-fold), COX-2 (0.705-fold), increasing IL-10 (1.84-fold), suggesting neuroinflammation modulation. Antioxidant (SOD, CAT, GST, GSH) upregulated. These findings indicate SHLP-6’s as agent sulfate-induced

Language: Английский

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