Bridging basic science and clinical practice in orthopaedic translational research

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 50, P. A1 - A4

Published: Jan. 1, 2025

Language: Английский

Inhibiting synovial inflammation and promoting cartilage repair in rheumatoid arthritis using a matrix metalloproteinase-binding hydrogel

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101792 - 101792

Published: April 23, 2025

Originating from synovial tissue, matrix metalloproteinase-9 (MMP-9) is a key inflammatory factor that promotes the formation and invasion of pannus, leading to cartilage destruction in rheumatoid arthritis (RA). However, clinical trials systemic use MMP-9 inhibitors are not successful due severe side effects. Thus, locally inhibiting may be an alternative treatment RA. Herein, we developed binding peptide-functionalized copper sulfide nanoparticles (CuS-T NPs) delivered them with light crosslinking chondroitin sulfate methacrylate (ChSMA) hydrogel. We found CuS NP-doped hydrogels could inhibit inflammation. Specifically, CuS-T/ChSMA hydrogel rapidly bind MMP-9, thereby only RA fibroblast-like synoviocytes but also polarization M1-type macrophages. The underlying mechanism involved inhibition MAPK pathway. Moreover, ChSMA provided matrix-mimic microenvironment synergistically promoted generation collagen-2 aggrecan NPs. In adjuvant-induced mouse model, intra-articular injection ChSMA/CuS-T significantly alleviated inflammation accelerated repair without causing any effects, killing two birds one stone therapy.

Language: Английский

Cascade-Targeting Hydrogel Microspheres with Biomimetic Nanoparticles Enable Multifaceted Anti-Inflammatory and Antioxidant Defense for Osteoarthritis Management

Published: Jan. 1, 2025

Language: Английский