Elevated plasma Tau-PT217 linked to decreased hippocampal functional connectivity in patients with knee osteoarthritis

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149478 - 149478

Published: Jan. 1, 2025

Language: Английский

Locus coeruleus microstructural integrity is associated with vigilance vulnerability to sleep deprivation

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(13)

Published: Sept. 1, 2024

Insufficient sleep compromises cognitive performance, diminishes vigilance, and disrupts daily functioning in hundreds of millions people worldwide. Despite extensive research revealing significant variability vigilance vulnerability to deprivation, the underlying mechanisms these individual differences remain elusive. Locus coeruleus (LC) plays a crucial role regulation sleep-wake cycles has emerged as potential marker for deprivation. In this study, we investigate whether LC microstructural integrity, assessed by fractional anisotropy (FA) through diffusion tensor imaging (DTI) at baseline before can predict impaired psychomotor test (PVT) performance during deprivation cohort 60 healthy individuals subjected rigorously controlled in-laboratory study. The findings indicate that with high FA experience less impairment from compared those low FA. accounts 10.8% variance sleep-deprived PVT lapses. Importantly, relationship between is anatomically specific, suggesting integrity may serve biomarker loss.

Language: Английский

Effects of Dexmedetomidine on Depression-like Behaviour in Chronic Restraint Stress Mice: Involvement of Specific Brain Regions

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 734, P. 150479 - 150479

Published: July 30, 2024

Language: Английский