Bioanalysis,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 20
Published: March 24, 2025
Bioanalytical
laboratories
face
significant
challenges
in
sample
preparation
due
to
the
complexity
of
biological
matrices
and
low
concentrations
target
analytes.
This
review
focuses
on
advances
green
(GSP)
techniques
tailored
meet
these
while
promoting
sustainability.
Innovations
sorbents,
including
metal-organic
frameworks
(MOFs),
magnetic
nanoparticles
(MNPs),
sol-gel-based
materials,
molecularly
imprinted
polymers
(MIPs),
carbon-based
natural
sorbents
like
cellulose
kapok
fiber,
have
enhanced
extraction
efficiency
selectivity.
Green
solvents
such
as
deep
eutectic
(DES),
ionic
liquids
(ILs),
supramolecular
(SUPRAs),
switchable
hydrophilicity
(SHSs)
further
reduce
environmental
impact
by
minimizing
toxic
solvent
use.
highlights
their
use
drug
analysis,
emphasizing
roles
enhancing
efficiency,
selectivity,
Recent
applications
demonstrate
integration
into
bioanalytical
workflows,
significantly
improving
analytical
performance
adhering
Analytical
Chemistry
(GAC)
principles.
It
is
anticipated
that
this
comprehensive
will
aid
scholars
formulation
selective,
rapid,
environmentally
friendly,
straightforward,
sensitive,
precise
methodologies
for
bioanalysis,
thereby
innovation
sustainability
within
analysis
protocols.
Journal of Separation Science,
Journal Year:
2024,
Volume and Issue:
47(17)
Published: Aug. 31, 2024
In
this
work,
an
easy,
safe,
simple,
and
efficient
pH‐switchable
deep
eutectic
solvents
(DESs)‐based
liquid
phase
microextraction
followed
by
high‐performance
chromatography‐diode
array
detector
analysis
was
developed
for
the
determination
of
1,3‐dimethylamylamine
(DMAA).
The
switchability
obtained
DESs
investigated
changing
pH.
Then
best‐selected
DES
characterized
application
selected
in
extraction
DMAA
from
sports
nutrition
bodybuilding
supplements
investigated.
synthesized
l
‐menthol:
oleic
acid
a
molar
ratio
1:2
had
highest
efficiency
target
compound.
Under
optimum
conditions,
(50
µL
DES,
100
4
mol/L
KOH,
HCl,
time
40
s
without
salt
addition)
calibration
graph
linear
range
0.05–100
µg/kg
limit
detection
0.02
µg/kg.
relative
standard
deviations
including
intra‐day
inter‐day
10.0
real
samples
were
2.7%
(
n
=
7)
5.3%
7),
respectively.
enrichment
factor
percentage
recovery
method
283
85%,
recoveries
different
90%–109%.
