Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Cryobiology, Journal Year: 2025, Volume and Issue: 118, P. 105199 - 105199
Published: Jan. 14, 2025
Language: Английский
Citations
0Published: Jan. 1, 2025
Language: Английский
Citations
0Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 737 - 737
Published: Feb. 21, 2025
The health benefits of tea are primarily attributed to its chemical composition, particularly phenolic compounds. As a renowned from Guangdong, China, Xianhu (XHT) has not been thoroughly studied in terms composition or health-promoting properties. This study characterized the compounds water extract using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and evaluated antioxidant activity vitro. Furthermore, effects XHT extracts on reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), lipofuscin levels, lifespan Caenorhabditis elegans were assessed, alongside their modulation aging-related genes. Compared with Xinyang Maojian (XYMJ) Yingde black (YDBT), exhibited significantly higher polyphenol content, 23 identified as characteristic markers. demonstrated superior 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) inhibition capacities, greatest reductions ROS, MDA, highest upregulation SOD CAT activities. was 23.50% 21.07% longer than nematodes control group. Moreover, modulated 13 genes, which strongly correlated research results above indicators all obtained without affecting normal feeding reproductive capabilities C. elegans. These findings suggest that these phenolics key bioactive components responsible for anti-aging XHT.
Language: Английский
Citations
0American Journal of Analytical Chemistry, Journal Year: 2024, Volume and Issue: 15(09), P. 303 - 332
Published: Jan. 1, 2024
Language: Английский
Citations
3Folia Histochemica et Cytobiologica, Journal Year: 2024, Volume and Issue: 62(3), P. 145 - 153
Published: Aug. 28, 2024
Introduction. Periodontitis (PD) is a chronic inflammatory disease leading to alveolar bone loss. This study investigates the effect of nootkatone and regulatory mechanism in reducing periodontal inflammation loss rat model. Material methods. Twenty male Sprague-Dawley rats were divided into control, periodontitis, nootkatone-treated groups (45 or 90 mg/kg). Ligature induction method was adopted establish PD After 21 days, received daily gavage either saline for 10 days. Alveolar assessed using micro-CT. Histological analyses included hematoxylin eosin (H&E), tartrate-resistant acid phosphatase (TRAP), Masson's trichrome stainings. Immunohistochemistry heme oxygenase 1 (HO-1) nuclear factor erythroid-2 related 2 (Nrf2) performed tissues. Content cytokines IL-1β, IL-6, TNF-α gingival tissues around ligature ELISA kits. Malondialdehyde (MDA) level superoxide dismutase (SOD) activity analyzed Western blot NF-κB expression performed. Results. Nootkatone significantly reduced distance from cementoenamel junction crest (CEJ-ABC), enhanced mineral density (BMD), volume (BV), BV/total (TV) ratio ligature-induced rats. Higher dose (90 mg/kg) did not show more significant therapeutic than lower staining showed decreased osteoclasts' number improved architecture group. cell infiltration by nootkatone-treatment increased Nrf2 HO-1 protein level, suppressing MDA levels enhancing SOD activity. Conclusions. In model, effectively mitigates through Nrf2/HO-1 pathways. These findings suggest as promising agent treatment periodontitis.
Language: Английский
Citations
1Research in Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(5), P. 591 - 605
Published: Sept. 1, 2024
Doxorubicin chemotherapy is a widely used treatment for various cancers, including breast, ovarian, and uterine among others. However, long-term use can cause nephrotoxicity side effects. Some citrus flavonoids have demonstrated nephroprotective activity; therefore, this study aimed to test the effectiveness of
Language: Английский
Citations
1Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0