International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11888 - 11888

Published: Nov. 5, 2024

The structure-tissue exposure/selectivity relationship (STR) aids in lead optimization to improve drug candidate selection and balance clinical dose, efficacy, toxicity. In this work, butyrocholinesterase (BuChE)-targeted cannabidiol (CBD) carbamates were used study the STR correlation with observed efficacy/toxicity. CBD similar structures same molecular target showed similar/different pharmacokinetics.

Language: Английский