Evaluation of ATR–FTIR, HPLC–DAD, GC–MS, and GC–IR for the Analysis of 145 Street Drug Samples From Drug Checking Services DOI Open Access
Manuela Carla Monti, Melanie Bauer,

Konrad R. Koch

et al.

Drug Testing and Analysis, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Drug checking services (DCS) are entities that allow recreational drug users to have street samples analyzed. Diverse analytical methods applied for DCS, ranging from test strips mass spectrometry (MS). This work evaluates the performance and utility of common methodologies used DCS operating with off-site testing, while additionally assessing potential gas chromatography coupled vapor phase infrared spectroscopy (GC-IR). Gas MS (GC-MS), GC-IR, high-performance liquid diode array detector (HPLC-DAD) were evaluated based on analysis 145 obtained two Swiss DCS. Additionally, attenuated total reflection Fourier-transform (ATR-FTIR) was is briefly discussed. A combined 245 analytes (including adulterants cutting agents) detected. GC-MS presented greatest number detected compounds, a sensitivity 96% compared sum all analytes, followed by HPLC-DAD 82%, GC-IR showed limited 70%. underperformed regarding detection low-abundant main active ingredients in strongly adulterated samples. study discusses limitations strengths specific context providing insights into occurrence false declarations (differing results alleged identity) distributions agents Based our results, complementary approaches considered most valuable. Finally, promotion comprehensive guidelines quality suitability would be highly desired.

Language: Английский

The UHPLC-MS/MS method for the determination of 26 synthetic benzimidazole opioids (nitazene analogs) with isomers separation DOI
Olga Wachełko, Kaja Tusiewicz, Paweł Szpot

et al.

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2025, Volume and Issue: 260, P. 116796 - 116796

Published: March 5, 2025

Language: Английский

Citations

1
Navigating nitazenes: A pharmacological and toxicological overview of new synthetic opioids with a 2-benzylbenzimidazole core DOI
Marthe M. Vandeputte, Christophe P. Stove

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110470 - 110470

Published: April 1, 2025

Language: Английский

Citations

0
Evaluation of ATR–FTIR, HPLC–DAD, GC–MS, and GC–IR for the Analysis of 145 Street Drug Samples From Drug Checking Services DOI Open Access
Manuela Carla Monti, Melanie Bauer,

Konrad R. Koch

et al.

Drug Testing and Analysis, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Drug checking services (DCS) are entities that allow recreational drug users to have street samples analyzed. Diverse analytical methods applied for DCS, ranging from test strips mass spectrometry (MS). This work evaluates the performance and utility of common methodologies used DCS operating with off-site testing, while additionally assessing potential gas chromatography coupled vapor phase infrared spectroscopy (GC-IR). Gas MS (GC-MS), GC-IR, high-performance liquid diode array detector (HPLC-DAD) were evaluated based on analysis 145 obtained two Swiss DCS. Additionally, attenuated total reflection Fourier-transform (ATR-FTIR) was is briefly discussed. A combined 245 analytes (including adulterants cutting agents) detected. GC-MS presented greatest number detected compounds, a sensitivity 96% compared sum all analytes, followed by HPLC-DAD 82%, GC-IR showed limited 70%. underperformed regarding detection low-abundant main active ingredients in strongly adulterated samples. study discusses limitations strengths specific context providing insights into occurrence false declarations (differing results alleged identity) distributions agents Based our results, complementary approaches considered most valuable. Finally, promotion comprehensive guidelines quality suitability would be highly desired.

Language: Английский

Citations

1