Investigating causal relationships between the gut microbiota and inflammatory skin diseases: A Mendelian randomization study DOI Creative Commons
Yunfan Gu, Weimin Zhang, Wenting Zhao

et al.

Australasian Journal of Dermatology, Journal Year: 2024, Volume and Issue: 65(4), P. 319 - 327

Published: Feb. 28, 2024

Abstract Background Numerous inflammatory skin diseases are associated with the gut microbiota. Studies of association between microbiota and have yielded conflicting results owing to confounding factors, causal relationship them remains undetermined. Methods Two‐sample Mendelian randomization (MR) was used examine four common diseases: acne, psoriasis, urticaria atopic dermatitis. The summary statistics from largest available genome‐wide study meta‐analysis ( n = 13,266) conducted by MiBioGen consortium along were obtained FinnGen consortium. Causal relationships assessed using inverse variance weighted (IVW), median, MR‐Egger maximum likelihood methods, several sensitivity analyses performed ensure accuracy results. Finally, reverse multivariable MR verify robustness Results We found associations Bacteroidaceae [odds ratio (OR), 2.25; 95% confidence interval (CI), 1.48–3.42; p ivw 0.0001], Allisonella (OR, 1.42; CI, 1.18–1.70; 0.0002) Bacteroides 0.0001) Eubacterium fissicatena group psoriasis 1.22; 1.10–1.35; Intestinibacter 1.28; 1.13–1.45; 0.0001). These corrected for a false discovery rate. Sensitivity validate confirmed that not influenced effect. Conclusion Our revealed some risk factors diseases, providing new information on potential therapeutic targets. Additionally, possible gut–skin axis confirmed. Further research is required elucidate mechanisms underlying these relationships.

Language: Английский

Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier to alleviate intestinal inflammation by modulating Akkermansia muciniphila abundance DOI Creative Commons
Yumeng Wang, Chengxi Li, Jianping Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3901 - 3915

Published: June 8, 2024

The intestinal mucus barrier is an important line of defense against gut pathogens. Damage to this brings bacteria into close contact with the epithelium, leading inflammation. Therefore, its restoration a promising strategy for alleviating This study showed that

Language: Английский

Citations

15
Ginsenoside CK Alleviates DSS-Induced IBD in Mice by Regulating Tryptophan Metabolism and Activating Aryl Hydrocarbon Receptor via Gut Microbiota Modulation DOI
Yuan Liu, Xue Bai,

Huanyan Wu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(17), P. 9867 - 9879

Published: April 11, 2024

Dysbiosis of gut microbiota is believed to be associated with inflammatory bowel disease (IBD). Ginsenoside compound K (CK), the main metabolite Panax ginseng ginsenoside, has proven effective as an anti-inflammatory agent in IBD. However, mechanisms by which CK modulates ameliorate IBD remain poorly understood. Herein, demonstrated potential suppress release proinflammatory cytokines modulation. Notably, supplementation promoted restoration a harmonious balance microbiota, primarily enhancing populations Lactobacillus and Akkermansia. Furthermore, considerably elevated concentrations tryptophan metabolites derived from that could activate aryl hydrocarbon receptor. Overall, promising alleviative efficacy stemmed promotion growth production metabolites, suggesting should regarded prospective prebiotic for future.

Language: Английский

Citations

11
Postbiotic Administration Ameliorates Colitis and Inflammation in Rats Possibly through Gut Microbiota Modulation DOI
Cuijiao Feng, Chuantao Peng,

Weiqin Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: April 10, 2024

Postbiotics are preparations of inanimate microorganisms and/or their components that beneficial to host health. Compared with probiotics, the postbiotic dose required for exerting obvious protective effects is unknown. Thus, we conducted a dose-dependent intervention study in dextran sulfate sodium (DSS)-induced colitis rats. The trial included five rat groups, including: control without DSS/postbiotic treatment, group C; 7-day DSS D; 14-day low, medium, and high probiotic doses (0.1, 0.2, 0.4 g/kg; groups L, M, H, respectively) after induction. We found effectively mitigated symptoms inflammation rats, evidenced by improved spleen index, less severe colon tissue damage, changes serum cytokine levels (decreases tumor necrosis factor-α interleukin-1β; increase interleukin-10) compared D. Moreover, therapeutic effect was dose-dependent. Fecal metabolomics analysis revealed recipients had more anti-inflammatory metabolites, namely, salicyloyl phytophingosine, podophylloxin, securinine, baicalein, diosmetin. metagenomics microbes pro-inflammatory bacteria. This confirmed postbiotics effective alleviating manner. Our findings interest food scientists, clinicians, health industry.

Language: Английский

Citations

9
An Evaluation of Sex-Specific Pharmacokinetics and Bioavailability of Kokusaginine: An In Vitro and In Vivo Investigation DOI Creative Commons

Kaiqi Shang,

Chengyu Ge,

Yindi Zhang

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1053 - 1053

Published: Aug. 9, 2024

Kokusaginine is a bioactive ingredient extracted from Ruta graveolens L., which has range of biological activities. Its pharmacokinetic (PK) properties are particularly important for clinical applications; however, they have not been fully elucidated. In addition, the effect sex differences on drug metabolism increasingly being recognized, but most studies ignored this factor. This study aims to fill knowledge gap by taking an in-depth look at PK kokusaginine and how gender affects its distribution in body. It also lays foundation development. study, sensitive ultra-high-performance liquid chromatography (UPLC) method was developed validated quantifying Sprague Dawley (SD) rat plasma tissue homogenates. Metabolic stability evaluated vitro using gender-specific liver microsomes. Innovatively, we incorporated as variable into both vivo SD rats, analyzing key parameters with Phoenix 8.3.5 software. The UPLC demonstrated high sensitivity precision, essential analysis. Notably, revealed pronounced sex-dependent metabolic variability (p < 0.05). vivo, significantly affected Area Under Moment Curve (AUMC)(0-∞) parameter 0.05) AUMC(0-t) brain 0.0001), underscoring necessity sex-specific assessments. calculated absolute bioavailability 71.13 ± 12.75% confirmed favorable oral absorption kokusaginine. Additionally, our innovative tissue-plasma partition coefficient (Kp) analysis highlighted rapid uniform pattern. presents sex-inclusive evaluation kokusaginine, offering novel insights profile distribution. These findings instrumental informing medication practices, dosage optimization, nuanced understanding efficacy safety context.

Language: Английский

Citations

9
Amplification of benzo[a]pyrene toxicity persistence in earthworms by polystyrene nanoplastics: From organismal health to molecular responses DOI
Ning Sun, Shaoyang Hu, Xingchen Zhao

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137091 - 137091

Published: Jan. 5, 2025

Language: Английский

Citations

1
Integrating network pharmacology to investigate the mechanism of quercetin's action through AKT inhibition in co-expressed genes associated with polycystic ovary syndrome and endometrial cancer DOI
Mengyuan Li,

Yewei Cui,

Xue‐Ru Wu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 297, P. 139468 - 139468

Published: Jan. 5, 2025

Language: Английский

Citations

1
Cannabidiol restores hematopoietic stem cell stemness in mouse through Atf2–Lrp6 axis after acute irradiation DOI Creative Commons
Zhijie Bai,

Congshu Huang,

Huanhua Xu

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(2)

Published: Feb. 1, 2025

Abstract Bone marrow serves as the residence of hematopoietic stem cells and is recognized one most radiosensitive tissues. Exposure to acute radiation leads severe damage bone hematopoiesis which can be fatal, while few clinically applicable medication or specific therapeutic targets have been discovered. In this study, we found that administration cannabidiol significantly enhanced individual survival restored reconstitution capacity within 14 days after irradiation. Single‐cell RNA sequencing analysis demonstrated expression levels genes associated with stemness along Wnt BMP signaling pathways were by treatment through upregulation Atf2 , a transcription factor possessing multifunctional properties. induced potentially upregulated Lrp6 improve cells. Further functional experiments validated crucial role in regulating multilineage differentiation potential progenitor Overall, our findings provide evidence for promising radioprotective function candidate target radiation‐induced injury, thereby paving way future research field.

Language: Английский

Citations

1
Polygonatum cyrtonema Hua polysaccharide alleviates ulcerative colitis via gut microbiota-independent modulation of inflammatory immune response DOI

Jin-Yang Shi,

Yong‐Jian Wang, Qing Bao

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 356, P. 123387 - 123387

Published: Feb. 16, 2025

Language: Английский

Citations

1
The causal relationship between gut microbiota and bone mineral density: a Mendelian randomization study DOI Creative Commons
Ying Wang, Xuejian Zhang, Guangjun Tang

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 23, 2023

Background The gut microbiota has emerged as an intriguing and potentially influential factor in regulating bone health. However, the causal effect of on mineral density (BMD) appears to differ throughout various life stages. Methods We conducted a Mendelian randomization (MR) analysis investigate potential relationship between BMD five distinct age groups: 0–15, 15–30, 30–45, 45–60, 60 years older. employed three different methods, namely MR-Egger, weighted median, Inverse-variance weighting, ensure robustness our findings, series sensitivity analyses were also conducted, such horizontal pleiotropy tests, heterogeneity leave-one-out tests. Results In group 0–15 years, Eubacterium_fissicatena _group Eubacterium_hallii identified risk factors for BMD. During 15–30 group, Phascolarctobacterium , Roseburia Ruminococcaceae _UCG_003 found be protective 30–45 Lachnospira genus demonstrated BMD, while Barnesiella Lactococcus Moving 45–60 Eubacterium_ventriosum _group, Lachnospiraceae _UCG_004, Subdoligranulum observed Eubacterium_coprostanoligenes Fusicatenibacter associated with increased individuals aged older, _UCG_002 noted Conversely, Eubacterium_ruminantium Ruminococcus_gauvreauii Alistipes Coprococcus _3 whereas Sellimonas Conclusion A robust exists all stages life, Firmicutes phylum being primary across groups. Gut linked primarily belong diversity phyla depicts relatively stable patterns during ages 0–45 years. 45 above, there is increase number species by trend toward Bacteroidetes categories proposed.

Language: Английский

Citations

17
Mesenchymal Stromal Cells: New Generation Treatment of Inflammatory Bowel Disease DOI Creative Commons

Shulin Wei,

Mingxing Li, Qin Wang

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 3307 - 3334

Published: May 1, 2024

Abstract: Inflammatory bowel disease (IBD) is a chronic inflammatory of the gastrointestinal tract, which has high recurrence rate and incurable due to lack effective treatment. Mesenchymal stromal cells (MSCs) are class pluripotent stem that have recently received lot attention their strong self-renewal ability immunomodulatory effects, large number experimental clinical models confirmed positive therapeutic effect MSCs on IBD. In preclinical studies, MSC treatment for IBD relies paracrine cell-to-cell contact, its mediated mitochondrial transfer immune regulation. It also plays role in restoring intestinal mucosal barrier through homing effect, regulation microbiome, repair epithelial cells. latest trials, safety efficacy been by transfusion autologous or allogeneic bone marrow, umbilical cord, adipose MSCs, as well derived extracellular vesicles. However, regarding stable use several concerns emerge, including cell sources, management (dose, route frequency administration, pretreatment MSCs) adverse reactions. This article comprehensively summarizes effects mechanisms advantages over conventional drugs, trial progress The current challenges future directions discussed. review would add knowledge into understanding applying MSCs. Keywords: mesenchymal cells, immunomodulation, disease, ulcerative colitis, Crohn's therapy

Language: Английский

Citations

7