Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 5545 - 5553
Published: April 1, 2025
We
aimed
to
explore
the
differences
of
neutrophil
elastase
(NE)
levels
between
intensive
care
unit
(ICU)
and
non-ICU
patients
with
COVID-19
infection,
as
well
its
predictive
value
for
progression.
enrolled
admitted
a
primary
diagnosis
COVID-19.
All
in
ICU
were
diagnosed
critical
type
upon
admission.
Blood
was
taken
within
24
hours,
followed
by
examination
blood
NE
level
urine
level.
Other
clinical
features
recorded.
A
logistic
regression
model
used
predict
total
83
diagnosed,
including
52
cases
31
cases.
The
group
showed
significantly
elevated
Neutrophil%,
Cr,
D-dimer
(DD),
Procalcitonin
(PCT),
C-reactive
protein
(CRP).
Meanwhile,
CD3-cell,
T4-cell,
Lymphocyte%
lower
group.
Notably,
similar
groups,
whereas
highly
higher
vs
After
dimension
reduction,
we
constructed
(UD)
using
only
two
factors:
DD
overall
accuracy
86.1%.
has
strong
efficacy
prediction
(AUC
=
0.893),
performance
UD
even
better
0.933).
Urine
is
useful
predictor
progression,
particularly
requiring
care.
positive
correlation
neutrophil%,
DD,
PCT,
negative
lymphocyte
levels.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 27, 2025
Although
an
ongoing
understanding
of
psoriasis
vulgaris
(PV)
pathogenesis,
little
is
known
about
the
proteomic
differences
between
moderate
and
severe
psoriasis.
In
this
cross-sectional
study,
we
evaluated
using
data-independent
acquisition
mass
spectrometry
(DIA-MS).
173
differentially
expressed
proteins
(DEPs)
were
significantly
two
groups.
Among
them,
85
upregulated,
while
88
downregulated
(FC
≥
±
1.5,
P
<
0.05).
Eighteen
DEPs
mainly
enriched
in
IL
−
17
signalling
pathway,
Neutrophil
extracellular
trap
formation,
degranulation
NF
kappa
B
which
associated
with
pathogenesis.
Ingenuity
pathway
Analysis
(IPA)
identified
TNF
TDP53
as
top
upstream
up-regulators,
Lipopolysaccharide
YAP1
potential
down-regulators.
The
main
active
pathways
antimicrobial
peptides
PTEN
signalling,
inhibitory
neutrophil
degranulation,
IL-8
signalling.
4D-parallel
reaction
monitoring
(4D-PRM)
suggested
that
KRT6A
Our
data
identify
biomarkers
disease
severity,
are
defence
response
to
bacterium.
Targeting
these
molecules
measures
manage
infection
may
improve
psoriasis's
severity
therapeutic
efficacy.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 7, 2025
It
is
estimated
that
more
than
150
million
individuals
alive
in
2020
had
survived
tuberculosis
(TB).
A
portion
of
this
large
population
continues
to
experience
chronic
respiratory
abnormalities,
with
or
without
symptoms,
due
previous
active
pulmonary
TB.
This
condition
known
as
Post-TB
Lung
Disease
(PTLD),
involves
a
complex
interaction
between
pathogen,
host
and
environmental
factors.
These
interactions
are
believed
drive
hyperinflammatory
process
the
lungs
during
TB,
resulting
tissue
damage,
which
may
lead
radiological
sequelae,
impaired
function,
clinical
such
cough,
dyspnea,
hemoptysis,
infections.
Such
complications
impose
significant
health,
financial,
social
burdens,
remain
poorly
understood
inadequately
addressed
by
health
care
systems.
Given
heterogeneity
immune
cells
their
products
infiltrating
airways
lung
parenchyma
acute
inflammation
caused
Mycobacterium
infection,
it
evident
TB
immunopathology
multifactorial.
Among
various
components
involved,
neutrophils
have
recently
emerged
critical
contributors
deleterious
response
against
leading
severe
damage.
In
translational
narrative
review,
we
aim
summarize
role
primary
-
proteases
(such
elastase),
matrix
metalloproteinases
extracellular
traps
(NETs)
We
highlight
new
concepts
emerging
evidence
neutrophil
involvement
disease,
translating
these
insights
from
"bench
bedside"
facilitate
dialogue
fundamental
researchers
practitioners.
Additionally,
present
potential
targets
for
future
treatment
strategies
could
mitigate
even
prevent
PTLD.
