A pan-cancer analysis of the oncogenic role of N-acetyltransferase 8 like in human cancer DOI Creative Commons
Jiamin Chen, Fanglin Shao, Shuxia Zhang

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 18, 2024

N-Acetyltransferase 8 Like (NAT8L) inhibits natural killer (NK)/T-cell cytotoxicity by impairing the formation of immunological synapse via N-acetylaspartate (NAA). Existing research has predominantly focused on metabolic functions NAT8L, particularly in adipose tissues and myelination brain. However, contrast to other N-acetyltransferases such as NAT1 NAT2, role NAT8L cancer been less extensively studied. In this study, we conducted a comprehensive pan-cancer analysis investigate carcinogenic human cancers. We utilized standardized TCGA dataset analyze differential expression, clinical prognosis, gene mutation, immune infiltration, epigenetic modification, tumor stemness, heterogeneity. Additionally, evaluated sensitivity small molecule drugs using GDSC CTRP databases. identified that expression was upregulated 6 cancers downregulated 12 compared normal tissues. analyzed its prognostic value 5 types (KIRP, COAD, COADREAD, GBMLGG, LUSC) found correlations with overall survival (OS), disease-specific (DSS), progression-free interval (PFI). Furthermore, significantly correlated levels most checkpoints, immunomodulators, cell infiltration. The mutation frequencies for bladder (BLCA), glioblastoma multiforme glioma (GBMLGG), lower-grade (LGG), KIRP were 1.2%, 0.9%, 0.8%, 0.4%, respectively. Our findings suggest may serve potential marker therapeutic target across variety cancers, KIRP, lung squamous carcinoma (LUSC).

Language: Английский

Lebanese cannabis oil as a potential treatment for acute myeloid leukemia: In vitro and in vivo evaluations DOI

Anthony Lteif,

Wassim N. Shebaby, Marissa El Hage

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118512 - 118512

Published: July 2, 2024

Language: Английский

Citations

3
Cannabidiol Enhances Atezolizumab Efficacy by Upregulating PD-L1 Expression via the cGAS–STING Pathway in Triple-Negative Breast Cancer Cells DOI Creative Commons
Bu Gyeom Kim,

Bo Ram Kim,

Dae Yeong Kim

et al.

Cancer Immunology Research, Journal Year: 2024, Volume and Issue: 12(12), P. 1796 - 1807

Published: Sept. 3, 2024

Abstract The treatment of patients with triple-negative breast cancer (TNBC) relies on cytotoxic therapy. Currently, atezolizumab and chemotherapy can be combined in TNBC. However, this approach is not effective for all patients, many tumors showing low responsiveness to atezolizumab. As there a lack alternative options, new anticancer drugs are urgently needed enhance activity against Recent strategies have focused regulating the expression programmed cell death ligand 1 (PD-L1) or enhancing immune response activation by combining checkpoint inhibitors. Cannabidiol (CBD), cannabinoid component derived from cannabis plant, has been reported therapeutic potential because its capacity induce apoptotic tumor cells while avoiding cytotoxicity normal cells. Previous studies demonstrated effects CBD apoptosis various types. role as an modulator regulation PD-L1 responses remains explored. In study, we found that stimulated TNBC occurred downstream CBD-mediated cyclic guanosine monophosphate-adenosine monophosphate synthase–stimulator interferon genes (cGAS–STING) pathway activation. Taken together, combination anti–PD-L1 enhances vitro vivo experiments. Our findings identified mechanism suggested could candidate development combinatorial inhibitors

Language: Английский

Citations

3
Molecular Targets for Cannabinoids in Natural Killer Cells: Do They Modulate the Antitumor Activity? DOI Creative Commons
Miguel Olivas-Aguirre,

Cecilia Gutiérrez-Iñiguez,

Igor Pottosin

et al.

Receptors, Journal Year: 2024, Volume and Issue: 3(2), P. 122 - 144

Published: March 25, 2024

Recent research has emphasized the potential of natural and synthetic cannabinoids as anticancer agents. Yet it remains unclear whether in which sense affect activity NK cells, an important branch immunity. Similar uncertainty exists regarding cells-based immunotherapy. Here we presented overview multiple cannabinoid targets canonical (mainly CB2) non-canonical receptors, ion channels, transporters, enzymes, expressed along with underlying molecular mechanisms. Through them, can viability, proliferation, migration, cytokine production, overall cells. Respective holistic studies are limited, and, mostly, phenomenological, not linking observed effects certain targets. Another problem existing is lack standardisation, so that diverse at variable concentrations ways administration applied, often, instead purified whole lymphocyte population used. Therefore, there urgent need for more focused, systemic, in-depth impact toolkit on cell function, to critically address compatibility synergies between utilization realm interventions.

Language: Английский

Citations

2
Integrated metabolomics and proteomics analyses to reveal anticancer mechanism of hemp oil extract in colorectal cancer DOI

Hengyuan Yu,

Chen Yang, Jiayin Deng

et al.

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 249, P. 116379 - 116379

Published: July 22, 2024

Language: Английский

Citations

2
Multi-omics strategy reveals that Cordyceps sinensis ameliorates sepsis-associated acute kidney injury via reprogramming of mitochondrial energy metabolism and macrophage polarization DOI Creative Commons
Lin Chen, Tong Yang,

Jiangpeng Wu

et al.

Acta Materia Medica, Journal Year: 2024, Volume and Issue: 3(3)

Published: Jan. 1, 2024

Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional medicine for the prevention, treatment, and prognostication of various diseases, because its pleiotropic pharmacological properties. However, potential action CS in sepsis-associated acute kidney injury (S-AKI) remains poorly understood. Herein, we investigated against S-AKI underlying mechanisms. treatment effectively ameliorated renal dysfunction mice with lipopolysaccharide (LPS)-induced S-AKI, indicated by suppression inflammatory cytokine expression secretion. Multi-omic analyses suggested that promotion mitochondrial energy metabolism might be mechanism through which protects induced LPS. Subsequent validation assays confirmed substantially restored activity complexes, membrane potential, ATP production. Moreover, concomitantly promoted transition M1 macrophages to M2 increased oxidative phosphorylation, thus indicating macrophage polarization may also target treatment. Our findings demonstrated significantly inflammation regulating polarization, providing new insights into clinical use prevention S-AKI.

Language: Английский

Citations

2
Lapachol inhibits the growth of lung cancer by reversing M2-like macrophage polarization via activating NF-κB signaling pathway DOI
Zhengzheng Zhang,

Luyao Bai,

Chunhua Lu

et al.

Cellular Signalling, Journal Year: 2023, Volume and Issue: 112, P. 110902 - 110902

Published: Sept. 24, 2023

Language: Английский

Citations

6
Research Progress on the Mechanism of the Antitumor Effects of Cannabidiol DOI Creative Commons
Li Ma, Mengke Liu,

Chuntong Liu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 1943 - 1943

Published: April 24, 2024

Cannabidiol (CBD), a non-psychoactive ingredient extracted from the hemp plant, has shown therapeutic effects in variety of diseases, including anxiety, nervous system disorders, inflammation, and tumors. CBD can exert its antitumor effect by regulating cell cycle, inducing tumor apoptosis autophagy, inhibiting invasion, migration, angiogenesis. This article reviews proposed mechanisms CBD, aiming to provide references for clinical treatment diseases rational use CBD.

Language: Английский

Citations

1
Icariside I enhances the effects of immunotherapy in gastrointestinal cancer via targeting TRPV4 and upregulating the cGAS-STING-IFN-I pathway DOI Creative Commons
Zhenhao Li, Zhian Chen, Yutong Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117134 - 117134

Published: July 15, 2024

Language: Английский

Citations

1
Natural compounds modulate the mechanism of action of tumour-associated macrophages against colorectal cancer: a review DOI Creative Commons
Weichen Yuan,

Jiexiang Zhang,

Haibin Chen

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(11)

Published: Nov. 15, 2024

Colorectal cancer (CRC) exhibits a substantial morbidity and mortality rate, with its aetiology pathogenesis remain elusive. It holds significant importance within the tumour microenvironment (TME) exerts crucial regulatory influence on tumorigenesis, progression, metastasis. TAMs possess capability to foster CRC pathogenesis, proliferation, invasion, metastasis, as well angiogenesis, immune evasion, resistance. Furthermore, can mediate prognosis of CRC. In this paper, we review mechanisms by which natural compounds target exert anti-CRC effects from perspective promotional CRC, mainly regulating polarization TAMs, reducing infiltration recruitment enhancing phagocytosis macrophages, signalling pathways cytokines, discuss potential value therapeutic strategies compounds-targeting pathway in clinical treatment.

Language: Английский

Citations

1
A cautionary tale of paradox and false positives in cannabidiol research DOI
Peter S. Cogan

Expert Opinion on Drug Discovery, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Decades of research on cannabidiol (CBD) have identified thousands purported cellular effects and many these been proposed to correlate with a vast therapeutic potential. Yet despite the large volume findings fueling broad optimism in this regard, few translated into any demonstrable clinical benefit or even notable side effects. Therein resides great paradox CBD: drug that appears affect almost everything

Language: Английский

Citations

1