Discover Oncology,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Dec. 18, 2024
N-Acetyltransferase
8
Like
(NAT8L)
inhibits
natural
killer
(NK)/T-cell
cytotoxicity
by
impairing
the
formation
of
immunological
synapse
via
N-acetylaspartate
(NAA).
Existing
research
has
predominantly
focused
on
metabolic
functions
NAT8L,
particularly
in
adipose
tissues
and
myelination
brain.
However,
contrast
to
other
N-acetyltransferases
such
as
NAT1
NAT2,
role
NAT8L
cancer
been
less
extensively
studied.
In
this
study,
we
conducted
a
comprehensive
pan-cancer
analysis
investigate
carcinogenic
human
cancers.
We
utilized
standardized
TCGA
dataset
analyze
differential
expression,
clinical
prognosis,
gene
mutation,
immune
infiltration,
epigenetic
modification,
tumor
stemness,
heterogeneity.
Additionally,
evaluated
sensitivity
small
molecule
drugs
using
GDSC
CTRP
databases.
identified
that
expression
was
upregulated
6
cancers
downregulated
12
compared
normal
tissues.
analyzed
its
prognostic
value
5
types
(KIRP,
COAD,
COADREAD,
GBMLGG,
LUSC)
found
correlations
with
overall
survival
(OS),
disease-specific
(DSS),
progression-free
interval
(PFI).
Furthermore,
significantly
correlated
levels
most
checkpoints,
immunomodulators,
cell
infiltration.
The
mutation
frequencies
for
bladder
(BLCA),
glioblastoma
multiforme
glioma
(GBMLGG),
lower-grade
(LGG),
KIRP
were
1.2%,
0.9%,
0.8%,
0.4%,
respectively.
Our
findings
suggest
may
serve
potential
marker
therapeutic
target
across
variety
cancers,
KIRP,
lung
squamous
carcinoma
(LUSC).
Life Medicine,
Journal Year:
2024,
Volume and Issue:
3(2)
Published: April 1, 2024
Abstract
The
advent
of
single-cell
sequencing
techniques
has
not
only
revolutionized
the
investigation
biological
processes
but
also
significantly
contributed
to
unraveling
cellular
heterogeneity
at
unprecedented
levels.
Among
various
methods,
transcriptome
stands
out
as
best
established,
and
been
employed
in
exploring
many
physiological
pathological
activities.
recently
developed
epigenetic
techniques,
especially
chromatin
accessibility
sequencing,
have
further
deepened
our
understanding
gene
regulatory
networks.
In
this
review,
we
summarize
recent
breakthroughs
methodologies.
Additionally,
describe
current
bioinformatic
strategies
integrate
data
obtained
through
these
methods
highlight
application
analysis
strategy
on
a
deeper
tumorigenesis
tumor
progression.
Finally,
discuss
challenges
anticipated
developments
field.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 15, 2024
Abstract
Background
Colorectal
cancer
(CRC)
progression
is
closely
related
to
the
tumor
microenvironment
(TME).
Tumor-associated
macrophages
(TAMs),
predominant
immune
cells
in
TME,
facilitate
proliferation,
invasion,
metastasis,
angiogenesis,
chemoresistance,
and
immunosuppression
CRC.TAMs
play
significant
roles
both
pathological
processes
therapeutic
strategies
of
CRC.
The
mutual
mechanisms
remain
unclear,
necessitating
an
in-depth
study
relationship
between
TAMs
This
paper
employs
bibliometric
methods
analyze
CRC
research
literature,
aiming
assess
current
trends,
evaluate
status,
forecast
future
directions
emerging
topics.
Methods
Publications
from
Web
Science
Core
Collection
(WOSCC)
database
were
searched
January
1,
2001,
July
31,
2024.
Following
establishment
specific
search
criteria
for
time,
publication
type,
language,
analysis
data
visualization
conducted
using
Microsoft
Excel,
R
software,
VOSviewer,
CiteSpace.
Results
included
1218
publications,
written
by
8,302
authors
61
countries
1,657
institutions,
published
427
journals,
covering
4,451
keywords
citing
65,174
references.
During
period
2017–2023,
number
publications
increased
rapidly.
most
cited
country
China.
leading
institutions
Sun
Yat
Sen
University,
Zhejiang
Chinese
Academy
Sciences,
all
located
Mantovani,
Alberto,
was
prolific
author
Humanitas
University.
primary
disciplines
molecular,
biology,
immunology,
medicine,
genetics.
Keyword
co-occurrence
literature
co-citation
identified
NF-κB
(nuclear
factor
kappa-B),
endothelial
growth
factor,
polarization,
response,
PD-1
blockade,
checkpoint
inhibitors,
metabolism
as
hotspots
trends
this
field.
Conclusion
employed
comprehensively
visualize
papers
2001
objective
hotspots,
development
targeting
CRC,
provide
a
reference
point
information
establish
novel
driving
force
treatment.
Discover Oncology,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Dec. 18, 2024
N-Acetyltransferase
8
Like
(NAT8L)
inhibits
natural
killer
(NK)/T-cell
cytotoxicity
by
impairing
the
formation
of
immunological
synapse
via
N-acetylaspartate
(NAA).
Existing
research
has
predominantly
focused
on
metabolic
functions
NAT8L,
particularly
in
adipose
tissues
and
myelination
brain.
However,
contrast
to
other
N-acetyltransferases
such
as
NAT1
NAT2,
role
NAT8L
cancer
been
less
extensively
studied.
In
this
study,
we
conducted
a
comprehensive
pan-cancer
analysis
investigate
carcinogenic
human
cancers.
We
utilized
standardized
TCGA
dataset
analyze
differential
expression,
clinical
prognosis,
gene
mutation,
immune
infiltration,
epigenetic
modification,
tumor
stemness,
heterogeneity.
Additionally,
evaluated
sensitivity
small
molecule
drugs
using
GDSC
CTRP
databases.
identified
that
expression
was
upregulated
6
cancers
downregulated
12
compared
normal
tissues.
analyzed
its
prognostic
value
5
types
(KIRP,
COAD,
COADREAD,
GBMLGG,
LUSC)
found
correlations
with
overall
survival
(OS),
disease-specific
(DSS),
progression-free
interval
(PFI).
Furthermore,
significantly
correlated
levels
most
checkpoints,
immunomodulators,
cell
infiltration.
The
mutation
frequencies
for
bladder
(BLCA),
glioblastoma
multiforme
glioma
(GBMLGG),
lower-grade
(LGG),
KIRP
were
1.2%,
0.9%,
0.8%,
0.4%,
respectively.
Our
findings
suggest
may
serve
potential
marker
therapeutic
target
across
variety
cancers,
KIRP,
lung
squamous
carcinoma
(LUSC).
