Non-Coding RNAs and Innate Immune Responses in Cancer

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2072 - 2072

Published: Sept. 11, 2024

Non-coding RNAs (ncRNAs) and the innate immune system are closely related, acting as defense mechanisms regulating gene expression immunity. Both modulators in initiation, development progression of cancer. We aimed to review major types ncRNAs, including small interfering (siRNAs), microRNAs (miRNAs), piwi-interacting (piRNAs), long non-coding (lncRNAs), with a focus on cancer, immunity, inflammation. found that ncRNAs related epigenetics, chronic inflammation, cancer share properties such inducibility, specificity, memory, transfer. These similarities interrelationships suggest trained together control can be combined develop novel therapeutic approaches for personalized treatment. In conclusion, close relationship between system, inflammation highlights their importance pathways potential targets strategies.

Language: Английский

Non-Coding RNAs in Breast Cancer: Diagnostic and Therapeutic Implications

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 127 - 127

Published: Dec. 26, 2024

Breast cancer (BC) is one of the most prevalent forms globally, and has recently become leading cause cancer-related mortality in women. BC a heterogeneous disease comprising various histopathological molecular subtypes with differing levels malignancy, each patient an individual prognosis. Etiology pathogenesis are complex involve considerable number genetic alterations dozens non-coding RNA expression. Non-coding RNAs part abundant family single-stranded molecules acting as key regulators DNA replication, mRNA processing translation, cell differentiation, growth, overall genomic stability. In context breast cancer, involved cycle control tumor migration invasion, well treatment resistance. Alterations expression may contribute to development progression making them promising biomarkers targets for novel therapeutic approaches. Currently, use not yet been applied routine practice; however, their potential very studied. The present review literature overview current knowledge its objective delineate function diverse classes particular emphasis on utility diagnostic prognostic markers or tools.

Language: Английский

Eugenol inhibits NEAT1 as a ceRNA in pre-cancerous breast lesions

Heliyon, Journal Year: 2024, Volume and Issue: 11(1), P. e41353 - e41353

Published: Dec. 19, 2024

Language: Английский