miR-135b: A Key Role in Cancer Biology and Therapeutic Targets DOI Creative Commons

Yingchun Shao,

Shuangshuang Zhang, Yuxin Pan

et al.

Non-coding RNA Research, Journal Year: 2025, Volume and Issue: 12, P. 67 - 80

Published: Feb. 21, 2025

miR-135b, a microRNA, is consistently up-regulated in various cancer tissues and cells, promoting progression. By inhibiting one or more target genes, miR-135b regulates phenotypes such as growth, apoptosis, migration, invasion, drug resistance, angiogenesis, establishing it critical driver of Additionally, regulated by oncogenes therapeutic drugs, highlighting its complexity potential. Significant progress has been made understanding miR-135b's impact on cell behavior, promising biomarker for diagnosis prognosis, well potential future therapies. However, despite the extensive research this topic, there no comprehensive review summarizing role mechanisms across different types. This aims to provide detailed overview biological characteristics regulatory targets, upstream signaling pathways, potential, including influence chemoresistance. The also addresses key controversies surrounding research, aiming deepen role, promote transformation clinical application, theoretical foundation developing effective treatment strategies.

Language: Английский

MicroRNAs in Parkinson’s disease: From pathogenesis to diagnostics and therapeutic strategies DOI

Dongying Zheng,

Jibing Chween

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
miR‐135b: A Potential Biomarker for Pathological Diagnosis and Biological Therapy DOI
Dezhi Yan,

Qingliu He,

Chunjian Wang

et al.

Wiley Interdisciplinary Reviews - RNA, Journal Year: 2025, Volume and Issue: 16(2)

Published: March 1, 2025

ABSTRACT MicroRNAs (miRNAs) are a class of endogenous non‐coding RNAs found in eukaryotes with post‐transcriptional regulatory functions. A variety miRNAs is differentially expressed cancer tissues and thus can be used as biomarkers. microRNA‐135b‐5p (miR‐135b) has been shown to involved the pathological processes neoplastic non‐neoplastic diseases. Under different conditions, miR‐135b tumor suppressive carcinogenic effects. regulates development cancer, including metabolism, proliferation, apoptosis, invasion, fibrosis, angiogenesis, immunomodulation, drug resistance. new biomarker for diagnosis prognosis, which potential clinical guidance. This article reviews relevant research on miR‐135B field tumors, biogenesis background miR‐135b, expression related targets signaling pathways mediating progression order sort out explore transformation value miR‐135b.

Language: Английский

Citations

0
miR-135b: A Key Role in Cancer Biology and Therapeutic Targets DOI Creative Commons

Yingchun Shao,

Shuangshuang Zhang, Yuxin Pan

et al.

Non-coding RNA Research, Journal Year: 2025, Volume and Issue: 12, P. 67 - 80

Published: Feb. 21, 2025

miR-135b, a microRNA, is consistently up-regulated in various cancer tissues and cells, promoting progression. By inhibiting one or more target genes, miR-135b regulates phenotypes such as growth, apoptosis, migration, invasion, drug resistance, angiogenesis, establishing it critical driver of Additionally, regulated by oncogenes therapeutic drugs, highlighting its complexity potential. Significant progress has been made understanding miR-135b's impact on cell behavior, promising biomarker for diagnosis prognosis, well potential future therapies. However, despite the extensive research this topic, there no comprehensive review summarizing role mechanisms across different types. This aims to provide detailed overview biological characteristics regulatory targets, upstream signaling pathways, potential, including influence chemoresistance. The also addresses key controversies surrounding research, aiming deepen role, promote transformation clinical application, theoretical foundation developing effective treatment strategies.

Language: Английский

Citations

0