Targeting NEDD8 in pediatric acute myeloid leukemia: an integrated bioinformatics and experimental approach DOI Creative Commons
Jian‐Jun Sun, Cui Liu, Guangli Yang

et al.

Hematology, Journal Year: 2025, Volume and Issue: 30(1)

Published: March 18, 2025

This study systematically explored the role of NEDD8 in pediatric acute myeloid leukemia (AML) through patient sample analysis, database mining, and vitro experiments. Our results demonstrated that was significantly overexpressed newly diagnosed AML patients associated with poor survival outcomes. Functional enrichment analysis TARGET further revealed a strong correlation between cancer-related pathways. In experiments showed knockdown inhibited proliferation cells (THP-1 MV4-11) induced cell cycle arrest. Collectively, these findings highlight critical pathogenesis suggest its potential as both prognostic biomarker therapeutic target.

Language: Английский

Targeting NEDD8 in pediatric acute myeloid leukemia: an integrated bioinformatics and experimental approach DOI Creative Commons
Jian‐Jun Sun, Cui Liu, Guangli Yang

et al.

Hematology, Journal Year: 2025, Volume and Issue: 30(1)

Published: March 18, 2025

This study systematically explored the role of NEDD8 in pediatric acute myeloid leukemia (AML) through patient sample analysis, database mining, and vitro experiments. Our results demonstrated that was significantly overexpressed newly diagnosed AML patients associated with poor survival outcomes. Functional enrichment analysis TARGET further revealed a strong correlation between cancer-related pathways. In experiments showed knockdown inhibited proliferation cells (THP-1 MV4-11) induced cell cycle arrest. Collectively, these findings highlight critical pathogenesis suggest its potential as both prognostic biomarker therapeutic target.

Language: Английский

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