Portable Homemade Magnetic Hyperthermia Apparatus: Preliminary Results DOI Creative Commons
Teresa Castelo-Grande, Paulo A. Augusto,

Lobinho Gomes

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(22), P. 1848 - 1848

Published: Nov. 19, 2024

This study aims to describe and evaluate the performance of a new device for magnetic hyperthermia that can produce an alternating field with adjustable frequency without need change capacitors from resonant bank, as required by other commercial devices. innovation, among others, is based on using capacitator bank dynamically adjusts frequency. To validate novel system, series experiments were conducted nanoparticles (MNPs) demonstrating device's effectiveness allowing us identify challenges associated design more powerful A computational model was also used allow determine best system configuration. The results obtained are consistent those studies same MNPs but equipment, confirming good developed (e.g., SAR values between 1.37 10.80 W/gMNP obtained, reaching temperatures above 43 °C obtained). equipment offers additional advantages, including being economical, user-friendly, portable.

Language: Английский

Fiber Bragg Grating Thermometry and Post-Treatment Ablation Size Analysis of Radiofrequency Thermal Ablation on Ex Vivo Liver, Kidney and Lung DOI Creative Commons
Sanzhar Korganbayev, Leonardo Bianchi,

Clara Girgi

et al.

Sensors, Journal Year: 2025, Volume and Issue: 25(1), P. 245 - 245

Published: Jan. 3, 2025

Radiofrequency ablation (RFA) is a minimally invasive procedure that utilizes localized heat to treat tumors by inducing tissue thermal damage. The present study aimed evaluate the temperature evolution and spatial distribution, size, reproducibility of zones in ex vivo liver, kidney, lung using commercial device, i.e., Dophi™ R150E RFA system (Surgnova, Beijing, China), compare results with manufacturer’s specifications. Optical fibers embedding arrays fiber Bragg grating (FBG) sensors, characterized 0.1 °C accuracy 1.2 mm resolution, were employed for thermometry during procedures. Experiments conducted all organs two different configurations: single-electrode (200 W 12 min) double-electrode 9 min). Results demonstrated consistent reproducible across organ types, variations distribution size influenced characteristics settings. Higher temperatures achieved liver; conversely, exhibited smallest zone lowest maximum temperatures. found electrodes min produced larger, more rounded areas compared single electrode min. Our findings support efficacy highlight need tailored parameters based on type tumor properties. This research provides insights into characterization systems optimizing techniques underscores importance accurate precise procedural planning enhance clinical outcomes.

Language: Английский

Citations

0
Solid lipid nanoparticles in pancreatic cancer treatment DOI Creative Commons
Matthew D. Dunn,

Lewis Dymock,

Clare Hoskins

et al.

BJC Reports, Journal Year: 2025, Volume and Issue: 3(1)

Published: April 11, 2025

Pancreatic cancer comes with one of the poorest prognoses all cancers and as such it is crucial that new therapies are developed to improve on current statistics. Currently, chemotherapy cornerstone pancreatic treatment several drugs, combinations drugs being utilised for their anti-cancer effect. However, has a dense stroma around tumour intratumoral bacteria which result in having difficulty penetrating or metabolised by rendering them inactive. The utilisation nanotechnology been huge area focus researchers worldwide most lipid-based, inorganic polymer-based nanoparticles. Solid lipid nanoparticles have studied since first published 1990s, poorly researched applications. Being composed physiological lipids, solid offer greatly reduced risk acute chronic toxicities arising compared polymeric They also possess ability circulation time, permeability, bioavailability many first-line chemotherapeutics.

Language: Английский

Citations

0
Advanced functionalized chitosan nanocomposites for hyperthermia-based cancer therapy DOI
Mohamed J. Saadh, Jayanti Makasana,

Suhas Ballal

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)

Published: May 12, 2025

Language: Английский

Citations

0
Portable Homemade Magnetic Hyperthermia Apparatus: Preliminary Results DOI Creative Commons
Teresa Castelo-Grande, Paulo A. Augusto,

Lobinho Gomes

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(22), P. 1848 - 1848

Published: Nov. 19, 2024

This study aims to describe and evaluate the performance of a new device for magnetic hyperthermia that can produce an alternating field with adjustable frequency without need change capacitors from resonant bank, as required by other commercial devices. innovation, among others, is based on using capacitator bank dynamically adjusts frequency. To validate novel system, series experiments were conducted nanoparticles (MNPs) demonstrating device's effectiveness allowing us identify challenges associated design more powerful A computational model was also used allow determine best system configuration. The results obtained are consistent those studies same MNPs but equipment, confirming good developed (e.g., SAR values between 1.37 10.80 W/gMNP obtained, reaching temperatures above 43 °C obtained). equipment offers additional advantages, including being economical, user-friendly, portable.

Language: Английский

Citations

0