A novel ratiometric BenzoBODIPY-Based fluorescent probe for the detection and imaging of Cysteine in living cells and zebrafish models DOI

Jiangming Fan,

Bin Lin,

Shuqi Tang

et al.

Talanta, Journal Year: 2024, Volume and Issue: 285, P. 127332 - 127332

Published: Dec. 5, 2024

Language: Английский

A lysosome-targeted fluorescent probe for fluorescence imaging of hypochlorous acid in living cells and in vivo DOI
Ke An, Jiaxin Fan, Bin Lin

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 316, P. 124316 - 124316

Published: April 19, 2024

Language: Английский

Citations

8
Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor DOI Creative Commons
Beatriz S. Cugnasca,

Frederico Duarte,

João L. Petrarca de Albuquerque

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: 457, P. 115881 - 115881

Published: July 9, 2024

A new chemosensor based on Seleno-BODIPY (4) was designed and synthesized for the rapid sensitive detection of CN–, F−, OH– ions in THF, exhibiting ultra-low limits 26.26 nM, 43.05 8.64 respectively, through a turn-on fluorescent process. The seleno-funcionalization step novel methodology developed by our group, allowing direct functionalization BODIPY core. This procedure involves quick reaction utilizing Ph2Se2 as selenium source, BPO (benzoyl peroxide), p-TSA (p-toluenesulfonic acid) acetonitrile, enabling production corresponding chalcogenated BODIPYs containing one to four groups, demonstrating its versatility. structure 4 confirmed HRMS, 1H, 13C, 77Se NMR, IR spectra, photophysical properties were also evaluated. applied detect dual-mode (UV–Vis fluorescence spectra), displaying ratiometric response. probe exhibited fast response time, visual color change from blue yellow, high sensitivity selectivity these analytes over other selected anions. Mechanistic investigation mass analysis revealed that anions occurs via an Aromatic Nucleophilic Substitution with phenylselenide leaving group.

Language: Английский

Citations

8
Elucidating Cuproptosis-Linked Redox Dynamics in Wilson Disease via a Reversible Ratiometric Fluorescence Strategy DOI

Shunping Zang,

Qingguo He, Yuyang Zeng

et al.

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Redox dynamics in Wilson's disease and cuproptosis were elucidated using a reversible ratiometric fluorescent probe, WD-Redox, providing insights into oxidative stress, copper metabolism disorders, therapeutic evaluations of d -penicillamine.

Language: Английский

Citations

0
Ammonia and temperature sensing applications using fluorometric and colorimetric microparticles and polymeric films doped with BODIPY-emitters DOI
Beatriz S. Cugnasca,

Frederico Duarte,

Hugo M. Santos

et al.

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(12)

Published: Nov. 17, 2024

Language: Английский

Citations

3
A selenide-based coumarin fluorescent probe for fluorescence imaging of hypochlorous acid in cells and zebrafish DOI
Yan He,

Taorui Yang,

Bin Lin

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(19), P. 8809 - 8817

Published: Jan. 1, 2024

A new selenide-based fluorescent probe was developed for rapid and sensitive detection of HOCl in living cells zebrafish.

Language: Английский

Citations

2
Imidazole-based probe for the “light-up” detection of hypochlorite ion based on protonation-deprotonation strategy: Applications in real samples DOI

Megha,

Paramjit Kaur, Kamaljit Singh

et al.

Dyes and Pigments, Journal Year: 2024, Volume and Issue: 228, P. 112249 - 112249

Published: May 29, 2024

Language: Английский

Citations

2
BODIPY: synthesis, modification, and applications in sensing and biomedicine DOI

Daniil Spector,

Daniil Abramchuk,

Vladislav Bykusov

et al.

Russian Chemical Reviews, Journal Year: 2024, Volume and Issue: 93(10), P. RCR5136 - RCR5136

Published: Oct. 1, 2024

BODIPY chromophores (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) are one of the most versatile fluorophores which commonly used in a variety scientific fields. The combination excellent photophysical properties with possibility easy chemical modification structure, and photostability determines application biomedicine, photocatalysis, analytical chemistry materials science. This review summarizes approaches to synthesis BODIPY, discussing both classical recently-published synthetic postfunctionalization approaches. An influence structure various methods on their potential applications science biosensorics also discussed.<br> bibliography includes 344 references.

Language: Английский

Citations

2
Fluorescent Discrimination of Cysteine, Homocysteine, and Glutathione in Urine Samples Using a novel Seleno-BODIPY Probe DOI
Beatriz S. Cugnasca, Hugo M. Santos,

Frederico Duarte

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(46), P. 12038 - 12049

Published: Jan. 1, 2024

Biothiols, such as cysteine (Cys), glutathione (GSH), and homocysteine (Hcy), play crucial roles in various physiological processes serve biomarkers for oxidative stress redox homeostasis.

Language: Английский

Citations

1
Leveraging Chlorination-Based Mechanism for Resolving Subcellular Hypochlorous Acid DOI Creative Commons

Fung Kit Tang,

L. C. N. TUCKER,

Maheshwara Reddy Nadiveedhi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 23, 2024

Abstract Hypochlorous acid (HOCl) is crucial for pathogen defense, but an imbalance in HOCl levels can lead to tissue damage and inflammation. Existing indicators employ oxidation approach, which may not truly reveal the chlorinative stress environment. We designed a suite of with new chlorination-based mechanism, termed HOClSense dyes, resolve sub-cellular compartments. dyes allow visualization both switch-on switch-off detection modes diverse emission colors, as well unique redshift emission. features minimalistic design impressive sensing performance terms selectivity, our also facilitates functionalization through click chemistry resolving subcellular HOCl. As proof concept, we targeted plasma membrane lysosomes mapping. With utilizing HOClSense, discovered STING pathway-induced production abnormal Niemann-Pick diseases. To best knowledge, this first indicator series

Language: Английский

Citations

0
A colorimetric and ratiometric fluorescent probe of hypochlorous acid and its bio-imaging application DOI

Yumiao Sheng,

Kedian Xu,

Zhenzhen Wang

et al.

Photochemical & Photobiological Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Language: Английский

Citations

0