Design and synthesis of new 1,3,4-thiadiazoles as antimicrobial and antibiofilm agents
Zeitschrift für Naturforschung C,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Abstract
This
study
assessed
the
in
vitro
antibacterial
and
antibiofilm
properties
of
new
1,3,4-thiadiazole
derivatives.
1
H
NMR
13
C
analyses
were
employed
to
confirm
structure
synthesized
compounds,
characterization
is
followed
by
assessments
their
efficacy
against
Bacillus
subtilis
NRRL
B478,
Staphylococcus
aureus
ATCC
29213,
Escherichia
coli
25922,
Pseudomonas
aeruginosa
27853,
as
well
for
antifungal
activity
Candida
albicans
90028
krusei
6258,
using
broth
microdilution
method.
Notably,
among
tested
compound
4a
exhibited
highest
antimicrobial
activity,
with
a
minimal
inhibitory
concentration
125
μg/mL
P.
27853
significant
achieving
94
%,
98
%
100
biofilm
inhibition
at
250,
500
1,000
μg/mL,
respectively.
Besides,
4h
achieved
81
89
S.
29213
respectively,
displayed
potent
this
bacterium.
Finally,
theoretical
ADME
compounds
-
analyzed
calculations.
has
consolidated
base
development
agents
advanced
our
understanding
potential
mode
action
biofilm-associated
infections.
Language: Английский
Design, Synthesis, and Antimicrobial Evaluation of Novel 5-Chloropyridine Oxalamide Conjugates as In Vitro and In Silico Inhibitors of E. coli DNA Gyrase and C. albicans Sterol 14α-Demethylase (CYP51)
Russian Journal of Bioorganic Chemistry,
Journal Year:
2025,
Volume and Issue:
51(2), P. 827 - 849
Published: April 1, 2025
Language: Английский