Substance Addiction Rehabilitation Drugs DOI Creative Commons
Shu Yuan, Sicong Jiang, Zhongwei Zhang

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 615 - 615

Published: May 10, 2024

The relapse rate of substance abusers is high, and addiction rehabilitation adjunct drugs need to be developed urgently. There have been numerous reports on blocking the formation addiction, but studies that can alleviate withdrawal symptoms are very limited. Both dopamine transporter (DAT) hypothesis D3 receptor (D3R) proposed. DAT activators reduce extracellular level, D3R antagonists neuron’s sensitivity dopamine, both which may exacerbate subsequently. partial agonist SK608 has biased signaling properties via G-protein-dependent pathway did not induce desensitization and, thus, a promising drug for symptoms. Drugs serotoninergic neurons or GABAergic anti-inflammatory auxiliary effects treatments. promote structural synaptic plasticity also discussed.

Language: Английский

The interaction between central and peripheral immune systems in methamphetamine use disorder: current status and future directions DOI Creative Commons
Sai Shi,

Yiwen Sun,

Gui‐Ying Zan

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 15, 2025

Methamphetamine (METH) use disorder (MUD) is characterized by compulsive drug-seeking behavior and substantial neurotoxicity, posing a considerable burden on individuals society. Traditionally perceived as localized central nervous system disorder, recent preclinical clinical studies have elucidated that MUD multifaceted influenced various biological systems, particularly the immune system. Emerging evidence suggests both peripheral responses play crucial role in initiation persistence of MUD. Conceptualizing it systemic process prompts significant inquiries regarding mechanisms communication between compartments. Also, whether this intercommunication could serve diagnostic biomarkers or therapeutic targets. This review begins offering an overview mechanistic pertaining to neuroimmune systems. Finally, future directions are suggested through integration innovative technologies multidimensional data promote translation basic research into interventions.

Language: Английский

Citations

1
High-cellulose diet ameliorates cognitive impairment by modulating gut microbiota and metabolic pathways in mice DOI
Moeka Tanabe, Kazuo Kunisawa, Isao Saito

et al.

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

1
Circuit-specific neural perturbations and recovery in methamphetamine addiction in a mouse model DOI

Pongpanot Wongveerakul,

Dania Cheaha,

Ekkasit Kumarnsit

et al.

Neuroscience Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138201 - 138201

Published: March 1, 2025

Language: Английский

Citations

0
Substance Addiction Rehabilitation Drugs DOI Creative Commons
Shu Yuan, Sicong Jiang, Zhongwei Zhang

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 615 - 615

Published: May 10, 2024

The relapse rate of substance abusers is high, and addiction rehabilitation adjunct drugs need to be developed urgently. There have been numerous reports on blocking the formation addiction, but studies that can alleviate withdrawal symptoms are very limited. Both dopamine transporter (DAT) hypothesis D3 receptor (D3R) proposed. DAT activators reduce extracellular level, D3R antagonists neuron’s sensitivity dopamine, both which may exacerbate subsequently. partial agonist SK608 has biased signaling properties via G-protein-dependent pathway did not induce desensitization and, thus, a promising drug for symptoms. Drugs serotoninergic neurons or GABAergic anti-inflammatory auxiliary effects treatments. promote structural synaptic plasticity also discussed.

Language: Английский

Citations

2