Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107367 - 107367

Published: Aug. 25, 2024

The metformin molecule dates back to over a century, but its clinical use started in the '50s. Since then, diabetics has grown constantly, with 150 million users today. therapeutic profile also expanded, improved understanding of novel mechanisms. Metformin major activity on insulin resistance, by acting receptors and mitochondria, most likely activation adenosine monophosphate-activated kinase. These associated mechanisms lead significant lipid lowering body weight loss. An anti-cancer action come up recent years, partly dependent mitochondrial phosphatidylinositol 3-kinase resistance occurring some malignant tumors. potential raise life-length is object large ongoing studies several basic investigations. present review article will attempt investigate behind these diverse activities benefits. may act transcriptional histone modification, DNA methylation miRNAs. age-associated inflammation (inflammaging) occur via nuclear factor erythroid 2 related changes gut microbiota. A senolytic activity, leading reduction cells senescent secretory phenotype, be crucial lifespan prolongation as well ancillary properties diseases, such Parkinson's disease. Telomere respiratory 1 peroxisome gamma proliferator coactivator 1-alpha. Very observations severe neurological disorders, amyotrophic lateral sclerosis frontotemporal dementia, have raised considerable hope.

Language: Английский