international journal high risk behaviors & addiction, Journal Year: 2024, Volume and Issue: 13(3)

Published: Sept. 30, 2024

Context: Non-alcoholic substance abuse is a major public health concern worldwide, with methamphetamine being the second most widely used non-alcoholic globally, and Iran ranks fifth in addiction. To date, no approved pharmacological or non-pharmacological treatment by Food Drug Administration has been introduced for use disorder (MUD). Therefore, various methods are currently utilized. One approach that gained attention transcranial-direct current stimulation (tDCS), clinical evaluations focused on it. Objectives: The aim of this review to assess effectiveness method improving symptoms individuals MUD. Methods: Databases were reviewed up October 10, 2023, both Persian English languages, using PubMed, Scopus, Web Science, Google Scholar, Science Direct, Scientific Information Database (SID), Noormags. Keywords MUD, tDCS, Addiction, Craving, Cognitive Function. Studies included based Population, Intervention, Comparison (sham active control), Outcomes (craving cognition), Study Design (randomized controlled trial). excluded if they involved brain mapping neuroimaging. Meta-analysis was conducted Standardized Mean Difference (SMD) compare tDCS sham intervention (P ≤ 0.05, two-tailed). Random effects models individual MUD data from studies reported end-of-treatment craving data. risk bias calculated Cochrane Risk-of-Bias Tool (RoB-2), meta-analysis Comprehensive Meta-Analysis Software. Results: A total 870 initially identified; twenty-three (mean age 30.13 ± 6.67) identified examined outcomes (e.g., craving, cognition). After removing heterogeneous studies, meta-analyses performed vs. control domain. We found reduced indicated medium large effect sizes (Hedges' g: -0.64; SMD -0.58, 95% CI -0.85 -0.30; I² = 10.71%, Q value: 8.96). Results showed complementary can be useful. DLPFC (F3, F4) commonly targeted region inhibition. However, number sessions their duration varied significantly across studies. Conclusions: This systematic reduce momentary cue-induced cravings. quality sample size different scales assessing cravings cognitive functions, leading inconsistencies. highlighted importance targeting due its role executive functions self-control, right-sided showing greater effectiveness. Emotional dysregulation such as anxiety depression, also noted, limited support emotion regulation. need larger RCTs, standardized measurement tools, detailed participant information improve understanding treating

Language: Английский