New Insights into Contradictory Changes in Brain-Derived Neurotrophic Factor (BDNF) in Rodent Models of Posttraumatic Stress Disorder (PTSD)

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(12), P. 3226 - 3243

Published: Sept. 16, 2024

Language: Английский

Treating Cognition in Schizophrenia: A Whole Lifespan Perspective

Healthcare, Journal Year: 2024, Volume and Issue: 12(21), P. 2196 - 2196

Published: Nov. 4, 2024

Background/Objectives: Cognitive impairment is a core feature of schizophrenia, affecting attention, memory, and executive function contributing significantly to the burden disorder. These deficits often begin before onset psychotic symptoms persist throughout life, making their treatment essential for improving outcomes functionality. This work aims explore impact these impairments at different life stages interventions that have been developed mitigate effects. Methods: narrative review examined literature searching approaches treat cognitive in schizophrenia across lifespan. Results: alterations appear psychosis onset, suggesting window primary prevention. Then, period relative stability with slight decline gives secondary eventually tertiary prevention more than two decades. Finally, another occurs from third decade illness until later illness, when progression could be accelerated some cases. remediation physical exercise are evidence-based should provided all patients disabilities. Conclusions: Treating cognition whole lifespan crucial functional outcomes. It necessary consider need personalized, stage-specific strategies enhance functioning patients.

Language: Английский

NRN1 genetic variability and methylation changes as biomarkers for cognitive remediation therapy response in schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 136, P. 111175 - 111175

Published: Oct. 18, 2024

Language: Английский