Women s Health, Journal Year: 2024, Volume and Issue: 20

Published: Jan. 1, 2024

Background: Physiological and psychosocial changes experienced by women during the perinatal period may put them at risk for postpartum mental health disturbances. Accumulating evidence suggests that dietary patterns influence through modulation of gut microbiota its effects on host immune activity. Thus, targeting via intake could serve as both a preventative therapeutic strategy in improving health. Objectives: Here, we present protocol prospective cohort study primarily aims to determine if diet quality pregnancy is protective against depression severity. Secondary objectives will examine microbiota- blood-based inflammatory markers be associated with relationship between prenatal severity, well associations additional outcomes. Methods Analysis: Dietary symptoms documented 100 pregnant 4 time points postpartum. Participants also provide stool blood samples same composition predicted function factors, respectively. Stool analyzed using 16S ribosomal RNA gene sequencing bioinformatics tools (QIIME 2/PICRUSt2). Inflammatory factors determined high-sensitivity antibody-based immunoassays. Statistical analyses include linear mixed models hierarchical effect models. Ethics: The was approved Research Ethics Boards Royal Ottawa Health Care Group (#2022002) University (#H-06-22-8013). Informed consent obtained from all participants before their enrollment. Discussion: Findings this help develop evidence-based recommendations potential interventions susceptible or suffering issues are accessible, noninvasive, have play role prevention treatment.

Language: Английский