From Genetics to Psychosocial Functioning: Unraveling the Mediating Roles of Cognitive Reserve, Cognition, and Negative Symptoms in First‐Episode Psychosis DOI Creative Commons
María Florencia Forte, Derek Clougher, Àlex G. Segura

et al.

Acta Psychiatrica Scandinavica, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

ABSTRACT Background Studies have shown associations between polygenic risk scores for educational attainment (PRS EA ), cognitive reserve (CR), cognition, negative symptoms (NS), and psychosocial functioning in first‐episode psychosis (FEP). However, their specific interactions remain unclear. This study aimed to investigate the mediating roles of CR, NS relationship PRS one year after a FEP. Additionally, we sought explore impact two subtypes on this relationship: diminished Expression (EXP‐NS) Motivation Pleasure (MAP‐NS). Methods A total 138 FEP participants, predominantly male (70%), with mean age 24.77 years (SD = 5.29), underwent genetic, clinical, assessments months enrollment. Functioning evaluation followed at one‐year follow‐up. To role functioning, serial mediation model was employed. Two further models were tested differential EXP‐NS MAP‐NS. Mediation analysis performed using PROCESS macro version 4.1 within SPSS 26. Results The revealed causal chain > CR cognition ( β −3.08, 95%CI [−5.73, −0.43], p 0.023). When differentiating by type NS, only significantly associated casual −0.17, 95% CI [−0.39, −0.01], < 0.05). Conclusions ‐specifically EXP‐NS‐ mediate association follow‐up patients. These results highlight potential personalized interventions based genetic predisposition.

Language: Английский

From Genetics to Psychosocial Functioning: Unraveling the Mediating Roles of Cognitive Reserve, Cognition, and Negative Symptoms in First‐Episode Psychosis DOI Creative Commons
María Florencia Forte, Derek Clougher, Àlex G. Segura

et al.

Acta Psychiatrica Scandinavica, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

ABSTRACT Background Studies have shown associations between polygenic risk scores for educational attainment (PRS EA ), cognitive reserve (CR), cognition, negative symptoms (NS), and psychosocial functioning in first‐episode psychosis (FEP). However, their specific interactions remain unclear. This study aimed to investigate the mediating roles of CR, NS relationship PRS one year after a FEP. Additionally, we sought explore impact two subtypes on this relationship: diminished Expression (EXP‐NS) Motivation Pleasure (MAP‐NS). Methods A total 138 FEP participants, predominantly male (70%), with mean age 24.77 years (SD = 5.29), underwent genetic, clinical, assessments months enrollment. Functioning evaluation followed at one‐year follow‐up. To role functioning, serial mediation model was employed. Two further models were tested differential EXP‐NS MAP‐NS. Mediation analysis performed using PROCESS macro version 4.1 within SPSS 26. Results The revealed causal chain > CR cognition ( β −3.08, 95%CI [−5.73, −0.43], p 0.023). When differentiating by type NS, only significantly associated casual −0.17, 95% CI [−0.39, −0.01], < 0.05). Conclusions ‐specifically EXP‐NS‐ mediate association follow‐up patients. These results highlight potential personalized interventions based genetic predisposition.

Language: Английский

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