PlacentalIgf1Overexpression Sex-Specifically Impacts Mouse Placenta Structure, Altering Offspring Striatal Development and Behavior DOI Creative Commons
Annemarie Carver,

Faith M Fairbairn,

Robert J. Taylor

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

ABSTRACT Insulin-like growth factor 1 (IGF1) is produced primarily in the placenta utero and an essential hormone for neurodevelopment. Specifically, how placental IGF1 production persistently influences brain unclear. This study evaluated effects of Igf1 overexpression on embryonic postnatal development, particularly striatum, a region highly linked to neurodevelopmental disorders. Placental was overexpressed via placental-targeted CRISPR manipulation. altered structure function distinctly females males. Early differences trajectory striatal as adult showed persistent changes cell composition dependent behavior while males were less affected outcomes. Overall, these results demonstrate that expression alters development ways relevant These findings expand our understanding influence neurodevelopment will aid identifying preventive interventions. GRAPHICAL

Language: Английский

PlacentalIgf1Overexpression Sex-Specifically Impacts Mouse Placenta Structure, Altering Offspring Striatal Development and Behavior DOI Creative Commons
Annemarie Carver,

Faith M Fairbairn,

Robert J. Taylor

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

ABSTRACT Insulin-like growth factor 1 (IGF1) is produced primarily in the placenta utero and an essential hormone for neurodevelopment. Specifically, how placental IGF1 production persistently influences brain unclear. This study evaluated effects of Igf1 overexpression on embryonic postnatal development, particularly striatum, a region highly linked to neurodevelopmental disorders. Placental was overexpressed via placental-targeted CRISPR manipulation. altered structure function distinctly females males. Early differences trajectory striatal as adult showed persistent changes cell composition dependent behavior while males were less affected outcomes. Overall, these results demonstrate that expression alters development ways relevant These findings expand our understanding influence neurodevelopment will aid identifying preventive interventions. GRAPHICAL

Language: Английский

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