Sulfation pathways in times of change DOI Creative Commons
Jonathan Wolf Mueller, Daniela Fietz, Irundika H.K. Dias

et al.

Essays in Biochemistry, Journal Year: 2024, Volume and Issue: 68(4), P. 379 - 382

Published: Dec. 1, 2024

Abstract Sulfation pathways are an essential part of overall sulfur metabolism. mainly about sulfate activation, and the making breaking biological esters. This special issue features some extended reflection on what was presented at SUPA 2023 meeting Pathways. Novel insights into synthesis analytics sulfate, sulfated conjugates, protein persulfides presented. Oxysterol sulfates as emerging sulfo-metabolites. enzymes discussed in various disease settings. also presents polysaccharide sulfotransferases their functional characterization. Finally, cytoplasmic highlighted with regards to impact DNA-modification, context endocrine disruptors. All all, thought-provoking findings, potential guide stimulate future research field sulfation beyond.

Language: Английский

Complex roles for sulfation in the toxicities of polychlorinated biphenyls DOI
Michael W. Duffel, Hans‐Joachim Lehmler

Critical Reviews in Toxicology, Journal Year: 2024, Volume and Issue: 54(2), P. 92 - 122

Published: Feb. 7, 2024

Polychlorinated biphenyls (PCBs) are persistent organic toxicants derived from legacy pollution sources and their formation as inadvertent byproducts of some current manufacturing processes. Metabolism PCBs is often a critical component in toxicity, relevant metabolic pathways usually include initial oxidation to form hydroxylated polychlorinated (OH-PCBs). Subsequent sulfation OH-PCBs was originally thought be primarily means detoxication; however, there strong evidence that it may also contribute toxicities associated with OH-PCBs. These contributions either the direct interaction PCB sulfates receptors or serving localized precursor for The catalyzed by cytosolic sulfotransferases, and, when transported into serum, these metabolites retained, taken up other tissues, subjected hydrolysis intracellular sulfatase(s) regenerate Dynamic cycling between lead further activation resulting Ultimate toxic endpoints such processes endocrine disruption, neurotoxicities, many others exposures This review highlights understanding complex roles can have research on varied mechanisms control roles.

Language: Английский

Citations

7
Steroid sulfatase and sulfotransferases in the estrogen and androgen action of gynecological cancers: current status and perspectives DOI Creative Commons
Tea Lanišnik Rižner,

Marija Gjorgoska

Essays in Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: July 12, 2024

Abstract Sulfatase (STS) and sulfotransferases (SULT) have important role in the biosynthesis action of steroid hormones. STS catalyzes hydrolysis estrone-sulfate (E1-S) dehydroepiandrosterone-sulfate (DHEA-S), while catalyze reverse reaction require 3-phosphoadenosine-5-phosphosulfate as a sulfate donor. These enzymes control concentration active estrogens androgens peripheral tissues. Aberant expression SULT genes has been found both, benign hormone-dependent diseases cancers. The aim this review is to present current knowledge on gynecological cancers, endometrial (EC) ovarian cancer (OC). EC most common OC lethal cancer. cancers primarily affect postmenopausal women therefore rely local production hormones from inactive precursors, either DHEA-S or E1-S. Following cellular uptake by organic anion transporting polypeptides (OATP) transporters (OAT), regulate formation androgens, thus disturbed balance between can contribute onset progression importance these estrogen long recognized, provides new data their regulation inhibition, potential prognostic biomarkers.

Language: Английский

Citations

1
Sulfation pathways in the maintenance of functional beta-cell mass and implications for diabetes DOI Creative Commons
Jonathan Wolf Mueller, Patricia Thomas, Louise T. Dalgaard

et al.

Essays in Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Abstract Diabetes Type 1 and 2 are widely occurring diseases. In spite of a vast amount biomedical literature about diabetic processes in general, links to certain biological only becoming evident these days. One such area biology is the sulfation small molecules, as steroid hormones or metabolites from gastrointestinal tract, well larger biomolecules, proteins proteoglycans. Thus, modulating physicochemical propensities different sulfate acceptors, resulting enhanced solubility, expedited circulatory transit, macromolecular interaction. This review lists evidence for involvement pathways maintenance functional pancreatic beta-cell mass implications diabetes, grouped into various classes sulfated biomolecule. Complex heparan sulfates might play role development beta-cells. The sulfolipids sulfatide sulfo-cholesterol contribute health. beta-cells, there very few with confirmed on some tyrosine residues, IRS4 molecule being one them. Sulfated hormones, estradiol-sulfate vitamin-D-sulfate, may facilitate downstream signaling following de-sulfation. Indoxyl metabolite intestine, that causes kidney damage, contributing disease. Finally, technological perspective, sulfate, heparin, chondroitin all be involved next-generation transplantation. Sulfation beta-cells through multiple mechanisms. A more coherent understanding diabetes will discussion guide future research.

Language: Английский

Citations

1
Sulphotransferase-mediated toxification of chemicals in mouse models: effect of knockout or humanisation of SULT genes DOI Creative Commons
Hansruedi Glatt, Walter Meinl

Essays in Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Abstract Cytosolic sulphotransferase (SULT) enzymes catalyse reactions involved in xenobiotic elimination and hormone regulation. However, SULTs can also generate electrophilic reactive intermediates from certain substrates, including the activation of carcinogens. Here, we review toxicological studies mouse strains with SULT status altered by genetic modification. Knockout have been constructed for Sult1a1, 1d1, 1e1, 2b1 4a1. In addition, transgenic are available human SULT1A1/2. Among knockout strains, reduced fertility (Sult1e1) early postnatal death (Sult4a1) were observed. contrast, Sult1a1 or Sult1d1 knockouts SULT1A1/2 transgenics healthy showed no obvious deficiencies. These used 13 chemicals. Manipulation system dramatically adverse effects many compounds; thus, very large differences levels DNA adducts formed liver other tissues seen some chemicals – up to 99.2% decreases 83-fold increases transgenics. cases, these changes restricted which corresponding expressed, arguing local activation. compounds, kidney was an important target tissue, due active transfer that organ, via circulation, sulphuric acid esters.

Language: Английский

Citations

1
Sulfation pathways in times of change DOI Creative Commons
Jonathan Wolf Mueller, Daniela Fietz, Irundika H.K. Dias

et al.

Essays in Biochemistry, Journal Year: 2024, Volume and Issue: 68(4), P. 379 - 382

Published: Dec. 1, 2024

Abstract Sulfation pathways are an essential part of overall sulfur metabolism. mainly about sulfate activation, and the making breaking biological esters. This special issue features some extended reflection on what was presented at SUPA 2023 meeting Pathways. Novel insights into synthesis analytics sulfate, sulfated conjugates, protein persulfides presented. Oxysterol sulfates as emerging sulfo-metabolites. enzymes discussed in various disease settings. also presents polysaccharide sulfotransferases their functional characterization. Finally, cytoplasmic highlighted with regards to impact DNA-modification, context endocrine disruptors. All all, thought-provoking findings, potential guide stimulate future research field sulfation beyond.

Language: Английский

Citations

0