Synergistic effects of Lespedeza and artichoke extracts in the therapy of chronic kidney disease: mechanisms and perspectives DOI Creative Commons
Zoya Serebrovska, Denis Tolstun, Nina Sykalo

et al.

KIDNEYS, Journal Year: 2025, Volume and Issue: 14(1), P. 63 - 70

Published: March 25, 2025

Chronic kidney disease (CKD) is a major global health issue associated with oxidative stress, inflammation, and fibrosis. Traditional pharmacological approaches have limitations due to side effects insufficient efficacy in the late stages of disease. This study explores potential combining Lespedeza (Lespedeza spp.) artichoke (Cynara scolymus) extracts CKD treatment. The nephroprotective effect extract manifested reduction albuminuria, nitrogen, creatinine levels urine. achieved through both direct antioxidant action, protecting membrane structures, DNA, mitochondria, indirect anti-inflammatory reducing NF-κB inflammasome activity, as well release pro-inflammatory cytokines chemokines. primarily attributed inhibition Wnt/β-catenin signaling pathway, which reduces fibrosis, suppression (IL-1β, IL-2, IL-6, TNF-α, NF-κB, TGF-β1), preventing progression chronic inflammation kidneys. Additionally, inhi­bits angiotensin-converting enzyme, renal hypertension tissue from damage. synergistic may provide multifactorial nephron protection, minimizing slowing fibrosis progression. A li­terature review confirms promise this approach highlights necessity further preclinical clinical stu­dies determine optimal dosing regimens for therapy.

Language: Английский

Synergistic effects of Lespedeza and artichoke extracts in the therapy of chronic kidney disease: mechanisms and perspectives DOI Creative Commons
Zoya Serebrovska, Denis Tolstun, Nina Sykalo

et al.

KIDNEYS, Journal Year: 2025, Volume and Issue: 14(1), P. 63 - 70

Published: March 25, 2025

Chronic kidney disease (CKD) is a major global health issue associated with oxidative stress, inflammation, and fibrosis. Traditional pharmacological approaches have limitations due to side effects insufficient efficacy in the late stages of disease. This study explores potential combining Lespedeza (Lespedeza spp.) artichoke (Cynara scolymus) extracts CKD treatment. The nephroprotective effect extract manifested reduction albuminuria, nitrogen, creatinine levels urine. achieved through both direct antioxidant action, protecting membrane structures, DNA, mitochondria, indirect anti-inflammatory reducing NF-κB inflammasome activity, as well release pro-inflammatory cytokines chemokines. primarily attributed inhibition Wnt/β-catenin signaling pathway, which reduces fibrosis, suppression (IL-1β, IL-2, IL-6, TNF-α, NF-κB, TGF-β1), preventing progression chronic inflammation kidneys. Additionally, inhi­bits angiotensin-converting enzyme, renal hypertension tissue from damage. synergistic may provide multifactorial nephron protection, minimizing slowing fibrosis progression. A li­terature review confirms promise this approach highlights necessity further preclinical clinical stu­dies determine optimal dosing regimens for therapy.

Language: Английский

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