Molecular Diversity, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 3, 2024
Language: Английский
Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(9), P. 105944 - 105944
Published: Aug. 1, 2024
A series of flavonol derivatives containing piperidine sulfonamide were designed and synthesized. The EC50 values for the curative tobacco mosaic virus (TMV) by Z6 Z22 108.2 102.7 μg/mL, respectively, outperforming control agent ningenmycin (NNM) with an value 253.8 μg/mL. Additionally, protective activity Z21 100.9 123.2 also surpassing NNM 203.7 Microscale thermophoresis (MST) molecular docking test showed that bound well coat protein (TMV-CP). biological safety had almost no effect on seed germination seedling growth. After treatment Z6, chlorophyll content superoxide dismutase (SOD) in leaves increased, while malondialdehyde (MDA) decreased. Therefore, has a high probability as potential antiviral agent.
Language: Английский
Citations
6
Pest Management Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Abstract BACKGROUND Fungal diseases of plants have a serious impact on the quality and yield crops, some traditional pesticides can no longer cope with this problem. Therefore, it is great significance to develop new high efficiency low toxicity. RESULTS A series flavonoid derivatives containing benzothiazole were designed synthesized. Among them, compounds V17 , V12 V13 had excellent inhibitory effect against Fusarium oxysporum f. sp. cucumerinu half‐maximal concentration (EC 50 ) values 1.2, 2.3, 3.2 μg/mL, which better than control drug Kresoxim‐methyl ( Km 37.8 μg/mL). The in vivo protective activity curative activities cucumber fusarium wilt caused by F. cucumerinum 82.4 60.5% at 200 (60.2 48.6%). In addition, could damage cell membrane mycelia, be confirmed determination cytoplasmic leakage, detection permeability, measurement malondialdehyde (MDA). Similarly, scanning electron microscopy (SEM) experiment optical microscope characterization provide direct evidence for destruction mycelium treated . CONCLUSION significantly reduced pathogenicity provided idea direction development green pesticides. © 2025 Society Chemical Industry.
Language: Английский
Citations
0
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
To develop antibacterial agents with a novel mechanism of action, series sulfone compounds containing 1,2,4-triazolo[4,3-a]pyridine were designed and synthesized by progressive molecular structure optimization. The activities some derivatives against the four plant pathogens Xanthomonas oryzae pv. (Xoo), oryzicola (Xoc), axonopodis citri (Xac), Pseudomonas syringae actinidiae (Psa) evaluated. Among them, compound K3 demonstrated significant Xoo, Xoc, Xac, EC50 values 1.5, 1.7, 4.9 mg/L, respectively. In greenhouse, exhibited protective activity 44.49% curative 42.51% rice bacterial leaf blight, which notably surpassed traditional thiodiazole-copper (24.65% 23.35%) bismerthiazol (34.69% 30.78%). Furthermore, can inhibit growth pathogenic bacteria inhibiting variety virulence factors (extracellular polysaccharides, biofilms, motile extracellular enzymes.). It also induced production reactive oxygen species (ROS) pathogens, leading to their death. Transcriptomic analysis revealed that impacts biosynthesis, biofilm formation, metabolic processes, enhancing plant's self-defense biochemical processes affecting carbohydrate transport metabolism resist pathogen invasion. Therefore, inhibition as strategy for controlling difficult-to-treat diseases presents promising approach discovery candidates.
Language: Английский
Citations
0
Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
Language: Английский
Citations
0
Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Language: Английский
Citations
0
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 16, 2025
Twenty-two chalcone derivatives containing thiourea and piperidine moieties were synthesized. The in vitro antifungal activities of these compounds against nine fungi evaluated. results demonstrated that a majority exhibited exceptional activities. Especially, K2 displayed the most potent fungicidal activity Phytophthora capsici (P. capsici), with half-effective concentration (EC50) 5.96 μg/mL, surpassing control drug azoxystrobin (Az, 25.2 μg/mL). vivo experiments conducted on pepper leaves fruits. It significant protective efficacy P. (95.3%) at 200 which surpassed Az (79.0%). Morphological investigations utilizing scanning electron microscopy (SEM) fluorescence (FM) unveiled disruptive impact mycelium. Moreover, mechanistic studies have capacity to disrupt integrity cellular membrane pathogenic fungi, influence lipid peroxidation processes within membrane, induce content release. These experimental findings provided new idea for effectively preventing plant fungal diseases developing novel green chemical pesticide products.
Language: Английский
Citations
0
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107779 - 107779
Published: Sept. 1, 2024
Language: Английский
Citations
1
Computational Biology and Chemistry, Journal Year: 2024, Volume and Issue: 113, P. 108206 - 108206
Published: Sept. 12, 2024
Language: Английский
Citations
1
Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4496 - 4496
Published: Sept. 22, 2024
2-Chloropyridine-3-carbonitrile derivative 1 was utilized as a key precursor to build series of linear and angular annulated pyridines linked 6-hydroxy-4,7-dimethoxybenzofuran moiety. Reaction substrate with various hydrazines afforded pyrazolo[3,4-b]pyridines. Treatment 1,3-N,N-binucleophiles including 3-amino-1,2,4-triazole, 5-amino-1H-tetrazole, 3-amino-6-methyl-1,2,4-triazin-5(4H)-one 2-aminobenzimidazole produced the novel pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrimidine, pyrido[3,2-e][1,2,4]tetrazolo[1,5-a]pyrimidine, pyrido[3′,2′:5,6] pyrimido[2,1-c][1,2,4]triazine benzo[4,5]imidazo[1,2-a]pyrido[3,2-e]pyrimidine, respectively. 1,3-C,N-binucleophiles cyanoacetamides 1H-benzimidazol-2-ylacetonitrile furnished 1,8-naphthyridines benzoimidazonaphthyridine. Moreover, reacting 5-aminopyrazoles gave pyrazolo[3,4-b][1,8]naphthyridines. Finally, reaction compound 6-aminouracils cyclic enamines yielded pyrimido[4,5-b][1,8]naphthyridines. Some synthesized products showed noteworthy antimicrobial efficiency against all types microbial strains. Structures compounds were established using analytical spectroscopic tools.
Language: Английский
Citations
1
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(45), P. 25034 - 25044
Published: Nov. 5, 2024
A series of myricetin derivatives containing diisopropanolamine were designed and synthesized. The in vitro inhibitory effects the target compounds on 9 fungal pathogens 3 bacterial also evaluated. A12 had best effect against Xanthomonas oryzae pv. (Xoo), with an EC50 value 4.9 μg/mL, which was better than zinc–thiazole (ZT: = 7.3 μg/mL) thiodiazole–copper (TC: 65.5 μg/mL); A25 Phomopsis sp. (Ps), 17.2 azoxystrobin (Az: 22.3 μg/mL). In vivo inhibition tests performed kiwifruit for rice leaves A12. At 200 curative activity leaf blight 40.7%, that ZT (37.2%) TC (32.9%), protective 44.8%, (39.5%) (34.6%). kiwi soft rot disease 70.1%, Az (62.8%). Preliminary elucidation possible mechanisms action carried out by experiments fluorescence microscopy, scanning electron formation biofilms, density functional theory calculations, so on.
Language: Английский
Citations
1