Furo[3,2-b]pyridine: Chemical synthesis, transformations and biological applications DOI Creative Commons

Sumayya Akram,

Sana Aslam, Nasır Rasool

et al.

Journal of Saudi Chemical Society, Journal Year: 2024, Volume and Issue: 28(5), P. 101906 - 101906

Published: July 20, 2024

The combination of heterocycles renders a new possibility to synthesize multicyclic compounds having improved biological activities. Furo[3,2-b]pyridine is fused heterocyclic ring system comprising furan attached at the third and second positions pyridine. These can be easily synthesized from versatile starting materials including pyridine, furan, benzofuran, benzopyridine via cycloaddition, cycloisomerization, multicomponent, cross-coupling, Dakin-type reactions by utilizing microwave, copper, palladium based catalysts. Among chemical transformations furo[3,2-b]pyridine derivatives, review covered acetylation, addition, condensation, chlorination, Suzuki coupling, Vilsmeier-Haack reaction, nucleophilic substitution reactions. has attracted remarkable attention researchers due its wide range pharmacological applications as antibiotic, antiviral, antifungal, anticancer, inhibitors nicotinic acetylcholine receptors, CLKs, e1F4A, DYRKIA, α-glucosidase β-glucosidase. purpose discuss chemistry title reported during 2019–2024.

Language: Английский

Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review DOI Creative Commons

Dana M. Odeh,

Mohanad Odeh,

Taghrid S. Hafez

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 366 - 366

Published: Jan. 17, 2025

Heterocyclic compounds, especially those containing the pyrazole moiety, are highly significant in organic chemistry and possess remarkable diverse biological properties. The 5-aminopyrazole derivatives key starting materials for synthesis of numerous bioactive compounds such as pyrazolopyridine, pyrazolopyrimidine, pyrazoloquinazoline, pyrazolotriazine derivatives. Many inspired by a wide spectrum activities medicinal applications antioxidants, anticancer agents, enzyme inhibitors, antimicrobials, anti-tuberculosis activities. This review summarizes recently reported methods fused pyrazole-based based on within last 5 years (2020 to present). One important goals this is illustrate future strategies design, development, utilization products potent drugs.

Language: Английский

Citations

1
Recent progress in the synthesis of imidazoquinoline derivatives DOI Creative Commons

Warda Jahangir,

Sumayya Akram,

Sana Aslam

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102270 - 102270

Published: April 1, 2025

Language: Английский

Citations

0
Innovative Silica-Supported Acid Catalyst for Sustainable Synthesis of Bioactive Pyrazoles: Insights into Mechanisms and Applications DOI Creative Commons
Afroz Aslam,

Uzma,

Umaima Hamed Al Hoqani

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(19), P. 19750 - 19763

Published: May 8, 2025

An innovative silica-bonded N-(propylaminobenzene)-sulfonic acid (SBPASA) catalyst was synthesized by immobilizing metanilic onto silica and characterized using advanced techniques, including FTIR, XRD, SEM/EDX, Raman spectroscopy, UV-visible analysis, BET surface area analysis. The exhibited a high of 306.9 m2/g, an optimal mesoporous diameter 31.4 Å, product yields (up to 98%), distinguishing it from previously reported silica-supported catalysts. This facilitated the efficient preparation 4,4'-(arylmethylene)-bis-(1H-pyrazol-5-ols) (4a-i) in solvent-free environment, resulting with variety functional groups. played critical role facilitating key reaction steps, Michael addition, Knoevenagel condensation, cyclization. demonstrated remarkable recyclability, retaining its catalytic activity up six consecutive cycles without significant loss efficiency. DPPH free radical scavenging assay employed assess antioxidant compounds. Compound 4c highest potency IC50 value 12.46 μg/mL. Molecular docking compound soybean lipoxygenase-1 (PDB ID: 3pzw) revealed binding energy (-7.9 kcal/mol), further supported iMODS normal-mode analysis indicating stable providing insights into conformational flexibility during interaction. work underscores SBPASA's utility as recyclable, sustainable for green transformations gateway bioactive compounds pharmaceutical relevance.

Language: Английский

Citations

0
Recent synthetic methodologies for pyrrolidine derivatives through multicomponent reactions DOI
Hina Fatima, Matloob Ahmad,

Muhammad Shahid Nazir

et al.

Synthetic Communications, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27

Published: May 15, 2025

Language: Английский

Citations

0
Regioselective Synthesis of N-Aryl Pyrazoles from Alkenyl Sulfoxonium Ylides and Aryl Diazonium Salts DOI

Ramesh Kumar Vishwakarma,

Raju Sen,

Shalu Deshwal

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

A convenient and practical method has been developed for synthesizing various N-aryl pyrazoles from vinyl sulfoxonium ylides diazonium salts. When using 1,3-disubstituted ylides, the reaction selectively yields 1,3,5-trisubstituted pyrazoles. On other hand, employing 2,3-disubstituted results in formation of 1,3,4-trisubstituted The proceeds through novel aryl diazene-derived ylide. Furthermore, this efficiently produces aniline derivatives a one-pot transformation. takes place under transition metal-free, mild conditions easily accessible starting materials, making it approach generating pharmaceutical chemistry.

Language: Английский

Citations

2
Furo[3,2-b]pyridine: Chemical synthesis, transformations and biological applications DOI Creative Commons

Sumayya Akram,

Sana Aslam, Nasır Rasool

et al.

Journal of Saudi Chemical Society, Journal Year: 2024, Volume and Issue: 28(5), P. 101906 - 101906

Published: July 20, 2024

The combination of heterocycles renders a new possibility to synthesize multicyclic compounds having improved biological activities. Furo[3,2-b]pyridine is fused heterocyclic ring system comprising furan attached at the third and second positions pyridine. These can be easily synthesized from versatile starting materials including pyridine, furan, benzofuran, benzopyridine via cycloaddition, cycloisomerization, multicomponent, cross-coupling, Dakin-type reactions by utilizing microwave, copper, palladium based catalysts. Among chemical transformations furo[3,2-b]pyridine derivatives, review covered acetylation, addition, condensation, chlorination, Suzuki coupling, Vilsmeier-Haack reaction, nucleophilic substitution reactions. has attracted remarkable attention researchers due its wide range pharmacological applications as antibiotic, antiviral, antifungal, anticancer, inhibitors nicotinic acetylcholine receptors, CLKs, e1F4A, DYRKIA, α-glucosidase β-glucosidase. purpose discuss chemistry title reported during 2019–2024.

Language: Английский

Citations

1