Yoga Practice as a Potential Sarcopenia Prevention Strategy in Indonesian Older Adults: A Cross-Sectional Study

Open Access Journal of Sports Medicine, Journal Year: 2025, Volume and Issue: Volume 16, P. 3 - 13

Published: Jan. 1, 2025

Background: Sarcopenia is characterized by the progressive loss of skeletal muscle mass and poses a significant health challenge for older adults increasing risk disability decreasing quality life. Yoga considers as low-risk beneficial exercise adults. This research aims to evaluate potential yoga practice preventive strategy against sarcopenia in Indonesian Methods: An observational cross-sectional was conducted including 41 aged 60– 87 years. The focused on key biomarkers functional assessments, serum insulin-like growth factor 1 (IGF-1) levels, telomere length, gait speed, hand grip strength, SARC-F questionnaire scores. Results: results showed that participants 71– 80 years who practiced more than year had significantly higher IGF-1 levels (p=0.04). While improvements scores were observed, these changes not statistically significant, no differences found length. Conclusion: associated with upper lower extremity though findings did influence shows an emerging adjuvant option but can be applied single prevention Keywords: aging, frailty, life,

Language: Английский

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Cardiovascular Diseases, Vital Organ Fibrosis, and Chronic Inflammation Associated with High-Intensity and/or High-Volume Exercise Training: Double-Edged Sword Effects of Vigorous Physical Activity in Elderly People and/or in Middle-Age Cancer-Therapy-Treated Patients

Journal of Functional Morphology and Kinesiology, Journal Year: 2025, Volume and Issue: 10(1), P. 33 - 33

Published: Jan. 15, 2025

Cardiotoxicity, cardiovascular diseases (CVDs), hypertension, hepatotoxicity, and respiratory problems occurring several months to years post-chemotherapy and/or radiotherapy are increasingly documented by scientists clinicians. Anthracyclines, for example, were discovered in the late 1960s be dose-dependently linked induced cardiotoxicity, which frequently resulted cardiomyopathy heart failure. Most of those changes have also been associated with aging. While it is well known that exercise can slow down cellular aging processes, lessen effects chemotherapy, improve effectiveness cancer treatments, prevent health general population, remains unclear how volume or intensity may affect overall benefits physical activity on health. For instance, higher rates sudden cardiac arrest coronary artery calcification found marathon ultra-marathon runners. Several additional pathological consequences reported recently many organs athletes. This review reports most recent evidence suggesting excessive deleterious These findings clear contrast popular belief all forms generally reduce therapies. In conclusion, high-intensity training (HIT) high-volume (HVT) should not recommended middle-age elderly people who had therapies order avoid an exacerbation long-term treatment vital organ structures functions.

Language: Английский

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EXamining the feasibility of exerCisE to manage symptoms of Lupus (EXCEL): a protocol for a randomised controlled pilot study

Lupus Science & Medicine, Journal Year: 2025, Volume and Issue: 12(1), P. e001382 - e001382

Published: Jan. 1, 2025

SLE is a chronic autoimmune disease that results in sustained hyperactivation of innate and adaptive immune cells widespread inflammatory damage. Regular exercise reduces symptoms including fatigue joint pain improves patient quality life. However, most individuals with are not sufficiently active to achieve these benefits, guidance on the optimal approach limited. EXCEL will examine feasibility conducting large-scale randomised controlled trial comparing effects remotely monitored, home-based, programme standard care for SLE. 30 females be recruited, those into Exercise (SLE-Ex) codesign progressive training plan support from research team. The aim each 12-week complete 150 min moderate (60-70% heart rate max, HRmax) or 90 vigorous (>70% per week. SLE-Ex encouraged independently (without support) weeks 13-18. Participants Control (SLE-Con) maintain habitual activity without 18 weeks. Measures acceptability reported, peripheral blood collected at 0, 12 explore whether frequency, phenotype metabolic profile lymphocyte subsets has changed. Biomarkers activity, self-reported measures fatigue, sleep health-related life also monitored timepoints. Blood compared healthy control (HC) group (n=15, age body mass index matched) baseline only. A favourable ethical opinion was given by South East Scotland Research Ethics Committee (22/SS/0082). Findings disseminated conferences published peer-reviewed journals. ISRCTN72757645.

Language: Английский

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Is Physical Exercise Beneficial for People with Primary Sjögren’s Syndrome? Findings from a Systematic Review

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 1455 - 1455

Published: Jan. 31, 2025

Background: The aim of the study was to identify and critically evaluate best available evidence on impact physical exercise patients with primary Sjögren’s syndrome. Methods: Studies were searched in four electronic databases (PubMed, Web Science, Scopus, SportDiscus) from their inception up September 2024. methodological quality included studies assessed using 10-point Physiotherapy Evidence Database (PEDro) scale Methodological Index for Non-Randomized (MINORS). Results: A total randomized controlled trials one comparative analyzed. training programs evaluated varied duration, ranging 12 28 weeks. Exercise found have a positive intra-group fatigue, life, functional capacity. However, does not demonstrate superior effects compared standard treatment improving life disease impact. Conclusions: It is essential increase number involving individuals syndrome across various conditions more comprehensively potential benefits.

Language: Английский

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The effects of acute and chronic exercise on immune markers of TH1/TH2 cells in older adults: a systematic review

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 11, 2025

Purpose Imbalance between Th1 and Th2 cells correlated with increased disease incidence, is well-documented in the older adult. Both acute chronic exercise induce a transient shift organic homeostasis, modulating immune system impacting balance cells. This review investigates impact of on markers adults. Methods study was conducted as systematic review, following PRISMA guidelines, databases including PubMed, Web Science, Embase, Science Direct, Scopus were searched until March 2024, identifying randomized controlled trials prospective observational studies that examined effects intracellular surface markers, cytokines, immunoglobulins Studies involving animal subjects, isolated cells, diseased patients, or exposure to medications drugs excluded. The quality selected assessed using Cochrane risk bias tool (ROB2), data organized presented tables figures. Results Fourteen 525 participants included analysis. An session significantly serum IL-4, IL-6, IL-10 levels immediately afterward, returning baseline within 1 hour at moderate high intensities. Chronic intensities reduced TNF-α, CD4/CD8 ratio, while increasing after 24 weeks. Intracellular, other not analyzed. Conclusion decreases TNF-α IL-6 levels, lowers increases weeks, aiding balance. Acute temporarily an hour, indicating short-term modulation Th1/Th2 Systematic Review Registration https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021244426 , Identifier CRD42021244426.

Language: Английский

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Combined Effects of Particulate Matter Exposure and Exercise Training on Neuroplasticity-Related Growth Factors and Blood–Brain Barrier Integrity

Atmosphere, Journal Year: 2025, Volume and Issue: 16(2), P. 220 - 220

Published: Feb. 15, 2025

Particulate matter (PM) negatively impacts brain health, while exercise training can mitigate these effects and promote health. However, the effect of interaction between PM exposure on health remains insufficiently explored. This study investigated neuroplasticity-related growth factors blood–brain barrier (BBB) integrity. Forty male C57BL/6 mice were randomly assigned to four groups as follows: control (CON, n = 10), (PM, (EX, with (PMEX, 10). interventions conducted over 8 weeks. The group showed significantly elevated levels malondialdehyde (MDA), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), S100 calcium-binding protein β (S100β), neuron-specific enolase (NSE) (p < 0.05) reduced superoxide dismutase (SOD), insulin-like factor-1 (IGF-1), brain-derived neurotrophic factor (BDNF), vascular endothelial (VEGF) compared CON EX groups. Conversely, demonstrated MDA, IL-6, TNF-α, S100β, NSE enhanced SOD, IGF-1, BDNF, VEGF group. PMEX exhibited attenuated benefits, showing higher lower SOD IGF-1 These findings suggest that induces oxidative stress, inflammation, BBB disruption downregulating factors. Exercise mitigates adverse by enhancing antioxidant activity, reducing upregulating factors, preserving protective may be partially diminished under conditions exposure.

Language: Английский

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EFINUTRILES Study: Integrative Extra Virgin Olive Oil and Multimodal Lifestyle Interventions for Cardiovascular Health and SLE Management

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1076 - 1076

Published: March 19, 2025

Objectives: To analyze the effects of combination Extra Virgin Olive Oil (EVOO) supplementation and a health-related lifestyle intervention on disease activity cardiovascular risk factors in Systemic Lupus Erythematosus (SLE). Methods: A total 38 women with SLE were randomly assigned to EVOO (n = 9) combined multicomponent health promotion physical exercise program (EVOO + HRLI) 15) or control (CG) 14) groups for 24 weeks. Baseline post-intervention assessments performed, collecting data activity, accrual damage, blood biochemical parameters, arterial stiffness Framingham score, anthropometric body composition measurements, factors. Results: No changes observed any group after intervention. For risk, significant differences systolic mean pressure, greater reductions HRLI (p 0.036 vs. p < 0.001; 0.017 0.001, respectively). The showed BFM BFP 0.042, 0.022, EVOO+ also triglycerides 0.001), Aix brachial 0.037), central pressure pulse 0.05), mass index 0.006), fat skeletal muscle 0.039) Conclusions: Our findings suggest that multidisciplinary integrating nutritional interventions, education, regular patients has potential significantly improve parameters. Thus, this approach into clinical practice alongside usual pharmacological treatments would be beneficial patients. Clinical Trial Registration: NCT05261529.

Language: Английский

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A narrative review of multidisciplinary rehabilitation in juvenile idiopathic arthritis

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

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Frailty assessment and outpatient pre-habilitation for adults undergoing allogeneic hematopoietic cell transplantation

Bone Marrow Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

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Exercise ameliorates cardiac injury induced by Nandrolone decanoate through downregulation of osteopontin and mTOR expressions

Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102932 - 102932

Published: April 29, 2025

Language: Английский

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