Physiotherapy and occupational therapy in rheumatoid arthritis: Bridging functional and comorbidity gaps DOI
Nur Azizah Allameen, Yi Wye Lai,

George J. Lian

et al.

Best Practice & Research Clinical Rheumatology, Journal Year: 2024, Volume and Issue: unknown, P. 102032 - 102032

Published: Dec. 1, 2024

Language: Английский

Advances in the study of artemisinin and its derivatives for the treatment of rheumatic skeletal disorders, autoimmune inflammatory diseases, and autoimmune disorders: a comprehensive review DOI Creative Commons
Zhiyong Long, Xiang Wang, Wei Xiao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 25, 2024

Artemisinin and its derivatives are widely recognized as first-line treatments for malaria worldwide. Recent studies have demonstrated that artemisinin-based antimalarial drugs, such artesunate, dihydroartemisinin, artemether, not only possess excellent properties but also exhibit antitumor, antifungal, immunomodulatory effects. Researchers globally synthesized artemisinin like SM735, SM905, SM934, which offer advantages low toxicity, high bioavailability, potential immunosuppressive properties. These compounds induce immunosuppression by inhibiting the activation of pathogenic T cells, suppressing B cell antibody production, enhancing differentiation regulatory cells. This review summarized mechanisms analogs modulate excessive inflammation immune responses in rheumatic skeletal diseases, autoimmune inflammatory disorders, through pathways including TNF, Toll-like receptors, IL-6, RANKL, MAPK, PI3K/AKT/mTOR, JAK/STAT, NRF2/GPX4. Notably, context NF-κB pathway, inhibits expression disrupting upstream cascades and/or directly binding to downregulates multiple downstream genes controlled NF-κB, chemokines their receptors. targets regulate various functions, apoptosis, proliferation, signal transduction, antioxidant responses, ultimately intervening systemic diseases organs kidneys, nervous system, skin, liver, biliary system modulating dysregulation responses. Ongoing multicenter randomized clinical trials investigating effects these on rheumatic, inflammatory, with aim translating promising preclinical data into applications.

Language: Английский

Citations

2
Worse Morning Energy Profiles Are Associated with Significant Levels of Stress and Decrements in Resilience in Patients Receiving Chemotherapy DOI Creative Commons

Alexandra Shelley,

Sueann Mark,

Astrid Block

et al.

Seminars in Oncology Nursing, Journal Year: 2024, Volume and Issue: 40(5), P. 151718 - 151718

Published: Aug. 20, 2024

Evidence suggests that lower levels of morning energy are associated with higher stress and resilience in patients receiving chemotherapy. Study purposes were to identify subgroups distinct profiles; evaluate for differences among the profiles demographic clinical characteristics, as well measures stress, resilience, coping.

Language: Английский

Citations

0
Effects of a symptom-titrated exercise program on fatigue and quality of life in people with post-COVID condition – a randomized controlled trial DOI Creative Commons
Andreas Barz, Joshua Berger,

Marco Speicher

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 16, 2024

Language: Английский

Citations

0
Physiotherapy and occupational therapy in rheumatoid arthritis: Bridging functional and comorbidity gaps DOI
Nur Azizah Allameen, Yi Wye Lai,

George J. Lian

et al.

Best Practice & Research Clinical Rheumatology, Journal Year: 2024, Volume and Issue: unknown, P. 102032 - 102032

Published: Dec. 1, 2024

Language: Английский

Citations

0