Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 98(2), P. 699 - 713
Published: Feb. 27, 2024
Alzheimer's disease (AD) is a progressive neurodegenerative and symptoms develop gradually over many years. The current direction for medication development in AD focused on neuro-inflammation oxidative stress. Amyloid-β (Aβ) deposition activates microglia leading to neurodegeneration induced by activation of COX-2 via NFκB p50 glioblastoma cells.
Language: Английский
Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 395 - 395
Published: March 26, 2024
Central neurological disorders are significant contributors to morbidity, mortality, and long-term disability globally in modern society. These encompass neurodegenerative diseases, ischemic brain traumatic injury, epilepsy, depression, more. The involved pathogenesis is notably intricate diverse. Ferroptosis neuroinflammation play pivotal roles elucidating the causes of cognitive impairment stemming from these diseases. Given concurrent occurrence ferroptosis due metabolic shifts such as iron ROS, well their critical central nervous disorders, investigation into co-regulatory mechanism has emerged a prominent area research. This paper delves mechanisms along with interrelationship. It specifically emphasizes core molecules within shared pathways governing neuroinflammation, including SIRT1, Nrf2, NF-κB, Cox-2, iNOS/NO·, how different immune cells structures contribute dysfunction through mechanisms. Researchers’ findings suggest that mutually promote each other may represent key factors progression disorders. A deeper comprehension common pathway between cellular holds promise for improving symptoms prognosis related
Language: Английский
Citations
18
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102476 - 102476
Published: Aug. 31, 2024
Language: Английский
Citations
14
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: July 3, 2024
As the most common cause of dementia, Alzheimer’s disease (AD) is characterized by neurodegeneration and synaptic loss with an increasing prevalence in elderly. Increased inflammatory responses triggers brain cells to produce pro-inflammatory cytokines accelerates Aβ accumulation, tau protein hyper-phosphorylation leading neurodegeneration. Therefore, this paper, we discuss current understanding how inflammation affects activity induce AD pathology, biomarkers possible therapies that combat for AD.
Language: Английский
Citations
8
Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 266 - 266
Published: Jan. 11, 2025
Dual inhibition of cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) is a recognized strategy for enhanced anti-inflammatory effects in small molecules, offering potential therapeutic benefits individuals at risk dementia, particularly those with neurodegenerative diseases, common cancers, diabetes type. Alzheimer’s disease (AD) the most cause acetylcholinesterase (AChE) key approach treating AD. Meanwhile, Caspase-3 catalyzes early events apoptosis, contributing to neurodegeneration subsequently Structure-based virtual screening US-FDA-approved molecules from ZINC15 database identified clozapine (CLOZ) as dual inhibitor COX-2 AChE, significant binding affinity. Further molecular docking CLOZ active site LOX also showed potential. Further, results were validated using dynamics simulation (MDS) studies, confirming docking. The MDS good interactions residues. was further assessed lipopolysaccharide (LPS)-challenged rats treated thirty days doses 5 10 mg/kg, p.o. demonstrated modulation COX-2, 5-LOX, Caspase-3, MDA LPS-induced brains. Additionally, expression level IL-10 measured. Our decrease levels MDA. decrement pro-inflammatory markers NF-κB, TNF-α, IL-6 an improvement TGF-β1. Overall, findings indicate that has neuroprotective against LPS-treated can be explored.
Language: Английский
Citations
1
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(7)
Published: July 1, 2024
Abstract Introduction Alzheimer's disease (AD), the main cause of dementia, is characterized by synaptic loss and neurodegeneration. Amyloid‐β (Aβ) accumulation, hyperphosphorylation tau protein, neurofibrillary tangles (NFTs) in brain are considered to be initiating factors AD. However, this hypothesis falls short explaining many aspects AD pathogenesis. Recently, there has been mounting evidence that neuroinflammation plays a key role pathophysiology causes neurodegeneration over‐activating microglia releasing inflammatory mediators. Methods PubMed, Web Science, EMBASE, MEDLINE were used for searching summarizing all recent publications related inflammation its association with disease. Results Our review shows how dysregulation influences pathology as well roles neuroinflammation, possible microglia‐associated therapeutic targets, top neuroinflammatory biomarkers, anti‐inflammatory drugs combat inflammation. Conclusion In conclusion, microglial reactions important pathogenesis need discussed more detail promising strategies.
Language: Английский
Citations
8
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102270 - 102270
Published: March 13, 2024
Language: Английский
Citations
7
European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 976, P. 176694 - 176694
Published: May 29, 2024
Language: Английский
Citations
5
Life, Journal Year: 2024, Volume and Issue: 14(7), P. 839 - 839
Published: July 1, 2024
Background: Despite the important clinical issue of cognitive impairment after moderate traumatic brain injury (TBI), there is currently no suitable treatment. Here, we used in vitro and vivo models to investigate effect Donepezil—an acetylcholinesterase (AChE) inhibitor—on acute period following injury, while focusing on neuroinflammation autophagy- mitophagy-related markers. Methods: The purpose study was potential neuroprotective effects TBI-induced cells donepezil treatment, study, therapeutic by analyzing TBI model involved injuring SH-SY5Y using a cell-injury controller then investigating at concentration 80 μM. made stereotaxic impactor for male C57BL/6J mice. Immuno-histochemical markers functions were compared 7 days treatment (1 mg/kg/day). Mice divided into four groups: sham operation with saline (18 mice each group). Donepezil administered within 4 h post-TBI. Results: In vitro, found lead increased cell viability 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimi-dazolylcarbocyanine iodide (JC-1), along decreased reactive oxygen species (ROS), lactate-dehydrogenase (LDH), 2′-7′-dichlorodihydrofluorescein diacetate (DCFH-DA)-positive cells, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells. mRNA protein expressions (Cyclooxygenase-2, COX-2; NOD-like receptor 3, NLRP3; Caspase-1; Interleukin-1 beta, IL-1β), as well (death-associated kinase 1, DAPK1; PTEN-induced PINK1; BCL2/adenovirus E1B 19 kDa protein-interacting 3-like, BNIP3L; Beclin-1, BECN1; BCL2-associated X protein, BAX; microtubule-associated 1A/1B-light chain 3B (LC3B); Sequestosome-1; p62) all decrease also showed that resulted levels cortical tissue losses swelling group without shown Western blotting markers, especially COX-2 BNIP3L, which most significant decreases. Moreover, an escape latency, alteration rate, improved preference index, altogether pointing better performance Conclusions: may be beneficial improving early phase ameliorating neuroinflammation, autophagy mitophagy.
Language: Английский
Citations
4
Current Behavioral Neuroscience Reports, Journal Year: 2025, Volume and Issue: 12(1)
Published: Jan. 23, 2025
Abstract Purpose of Review Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with multifaceted etiologies. Emerging evidence implicates dysregulation prostaglandins and cyclooxygenase (COX) enzymes in ASD pathophysiology. This review aims to explore key mechanisms through which COX may influence ASD. Recent Findings research highlights significant roles for modulating Wnt (Wingless Int-1) signalling pathways, are known autism susceptibility as well regulating dendritic arborisation cerebellar function. Polymorphisms genes have also been linked ASD, indicating genetic component this dysregulation. Furthermore, show potential biomarkers Summary The accumulated underscores the involvement insight offers deeper understanding pave way more effective diagnostic treatment strategies.
Language: Английский
Citations
0
Prostaglandins Leukotrienes and Essential Fatty Acids, Journal Year: 2025, Volume and Issue: unknown, P. 102665 - 102665
Published: Jan. 1, 2025
Language: Английский
Citations
0