GeroScience, Journal Year: 2020, Volume and Issue: 42(5), P. 1199 - 1216
Published: Aug. 7, 2020
Language: Английский
Therapeutic Advances in Neurological Disorders, Journal Year: 2019, Volume and Issue: 12
Published: Jan. 1, 2019
Acute brain ischemia causes changes in several neural networks and related cortico-subcortical excitability, both the affected area apparently spared contralateral hemisphere. The modulation of these processes through modern techniques noninvasive stimulation, namely repetitive transcranial magnetic stimulation (rTMS), has been proposed as a viable intervention that could promote post-stroke clinical recovery functional independence. This review provides comprehensive summary current evidence from literature on efficacy rTMS applied to different rehabilitative aspects stroke patients. A total 32 meta-analyses published until July 2019 were selected, focusing effects motor function, manual dexterity, walking balance, spasticity, dysphagia, aphasia, unilateral neglect, depression, cognitive function after stroke. Only conventional protocols considered this review, theta burst only excluded. Overall, HF-rTMS LF-rTMS have shown be safe well-tolerated. In addition, converges positive effect rehabilitation all manifestations stroke, except for spasticity impairment, where definitive cannot drawn. However, routine use specific paradigm recommended yet due significant level heterogeneity studies terms set outcome measures used. Future need preliminarily evaluate most promising before going multicenter with large cohorts patients order achieve translation into daily practice.
Language: Английский
Citations
195
Stroke, Journal Year: 2023, Volume and Issue: 54(12), P. 3202 - 3213
Published: Oct. 27, 2023
The Stroke Treatment Academic Industry Roundtable XII included a workshop to discuss the most promising approaches improve outcome from acute stroke. brought together representatives academia, industry, and government representatives. discussion examined in 4 epochs: pre-reperfusion, reperfusion, post-reperfusion, access stroke interventions. participants identified areas of priority for developing new existing treatments outcomes. Although many advances therapy have been achieved, more work is necessary reperfusion therapies benefit possible patients. Prioritization should help guide use resources investigator efforts.
Language: Английский
Citations
51
Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2019, Volume and Issue: 40(1), P. 3 - 22
Published: Oct. 23, 2019
After cerebral ischemia, events like neural plasticity and tissue reorganization intervene in lesioned non-lesioned areas of the brain. These processes are tightly related to functional improvement successful rehabilitation patients. Plastic remodeling brain is associated with limited spontaneous recovery Improvement depends on initial deficit, size, nature localization infarction, together sex age patient, all them affecting favorable outcome repair damaged areas. A better understanding pivotal design effective therapeutic strategies. Experimental models clinical studies have fueled current cellular molecular responsible for plastic remodeling. In this review, we describe known mechanisms, patients animal models, underlying contributing after ischemic stroke. We also discuss manipulations therapies that can stimulate plasticity. finally explore a new topic field stroke pathophysiology, namely brain-gut axis.
Language: Английский
Citations
103
Current Neurology and Neuroscience Reports, Journal Year: 2020, Volume and Issue: 20(1)
Published: Jan. 1, 2020
Language: Английский
Citations
86
Frontiers in Human Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: July 21, 2023
Rehabilitation approaches for individuals with neurologic conditions have increasingly shifted toward promoting neuroplasticity enhanced recovery and restoration of function. This review focuses on exercise strategies non-invasive neuromodulation techniques that target neuroplasticity, including transcranial magnetic stimulation (TMS), vagus nerve (VNS), peripheral (PNS). We chosen to focus due their greater potential integration into routine clinical practice. explore discuss the application these interventional in four neurological are frequently encountered rehabilitation settings: Parkinson’s Disease (PD), Traumatic Brain Injury (TBI), stroke, Spinal Cord (SCI). Additionally, we benefits combining rehabilitation, which has shown promise accelerating recovery. Our identifies studies demonstrate through combined selected patient populations. primarily motor aspects but also briefly address non-motor impacts conditions. identify gaps current literature barriers implementation highlight areas needing further research suggest avenues future investigation, aiming enhance personalization unique neuroplastic responses associated each condition. serves as a resource professionals researchers seeking comprehensive understanding interventions tailored specific diseases diagnoses.
Language: Английский
Citations
28
Neural Plasticity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 13
Published: Jan. 5, 2022
To determine the long-term effects of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) over contralesional M1 preceding motor task practice on interhemispheric asymmetry cortical excitability and functional recovery in subacute stroke patients with mild to moderate arm paresis.Twenty-four were randomly allocated either experimental or control group. The group underwent rTMS (1 Hz), immediately followed by 30 minutes (10 sessions within 2 weeks). controls received sham same practice. Following 2-week intervention period, was continued twice weekly for another 10 weeks both groups. Outcomes evaluated at baseline (T0), end period (T1), 12-week follow-up (T2).The MEP (paretic hand) asymmetry, Fugl-Meyer assessment, Action Research Arm Test, box block test scores improved more than T1 (p < 0.05). beneficial largely maintained T2.LF-rTMS effective enhancing ipsilesional upper limb function reducing paresis. Significance. Adding LF-rTMS prior may reduce excitabilities promote
Language: Английский
Citations
34
Neuropsychological Rehabilitation, Journal Year: 2019, Volume and Issue: 31(3), P. 479 - 505
Published: Dec. 27, 2019
There is continued interest in developing effective and innovative treatment approaches to manage improve outcomes after traumatic brain injury (TBI). Included this, the potential use of repetitive transcranial magnetic stimulation (rTMS), a neuromodulatory tool currently recommended by National Institute for Health Care Excellence as depression. This review considers application rTMS TBI, focussing on its therapeutic efficacy broad range sequalae, whether an optimal safe protocol can be determined, recommendations future clinical research work. Five databases (MEDLINE, CINAHL, PsychINFO, SCOPUS, Web Science) were electronically searched, identifying 30 empirical studies (single multiple subject case reports; randomized controlled trials) full review. Evidence suggests that has efficacious intervention symptoms including depression, dizziness, central pain, visual neglect. However, picture less encouraging prolonged disorders consciousness mixed cognitive outcomes. Overall, was well-tolerated patients, although some incidents side effects seizures have been reported. Recommendations are made more comprehensive guidelines sufficient reporting parameters procedures.
Language: Английский
Citations
51
Neurotherapeutics, Journal Year: 2020, Volume and Issue: 17(4), P. 2069 - 2088
Published: Aug. 27, 2020
Spinal cord injury (SCI) leads to a loss of sensitive and motor functions. Currently, there is no therapeutic intervention offering complete recovery. Here, we report that repetitive trans-spinal magnetic stimulation (rTSMS) can be noninvasive SCI treatment enhances tissue repair functional Several techniques including immunohistochemical, behavioral, cells cultures, proteomics have been performed. Moreover, different lesion paradigms, such as acute chronic phase following in wild-type transgenic animals at ages (juvenile, adult, aged), used. We demonstrate rTSMS modulates the scar by decreasing fibrosis inflammation increases proliferation spinal stem cells. Our results also decreases demyelination, which contributes axonal regrowth, neuronal survival, locomotor recovery after SCI. This research provides evidence induces effects preclinical rodent model suggests possible translation clinical application humans.
Language: Английский
Citations
50
Neurorehabilitation and neural repair, Journal Year: 2018, Volume and Issue: 32(11), P. 927 - 940
Published: Oct. 24, 2018
Background. Stroke is the leading cause of adult disability, but treatment options remain limited, leaving most patients with incomplete recovery. Patient and animal studies have shown potential noninvasive brain stimulation (NIBS) strategies to improve function after stroke. However, mechanisms underlying therapeutic effects NIBS are unclear there no consensus on which protocols effective. Objective. Provide a review articles that assessed repetitive transcranial magnetic (rTMS) direct current (tDCS) in stroke models. Methods. Articles were searched PubMed, including cross-references. Results. Nineteen eligible reporting rTMS or tDCS small rodents identified. Seventeen those described improved functional recovery neuroprotection compared untreated control sham-stimulated groups. The could be related molecular associated ischemic tolerance, neuroprotection, anti-apoptosis, neurogenesis, angiogenesis, neuroplasticity. Favorable outcome appeared effectively when using high-frequency (>5 Hz) intermittent theta burst ipsilesional hemisphere. strongly dependent polarity onset time. Although these findings promising, did not meet Good Laboratory Practice assessment criteria. Conclusions. Despite limited data availability, model demonstrate promote through different working mechanisms. Future models should adhere guidelines aim further develop clinically applicable by identifying favorable parameters, onset, adjuvant therapies, modes action.
Language: Английский
Citations
48
Journal of Rehabilitation Medicine, Journal Year: 2020, Volume and Issue: unknown, P. 0 - 0
Published: Jan. 1, 2020
To evaluate evidence from published systematic reviews of clinical trials to determine the effectiveness repetitive transcranial magnetic stimulation (rTMS) in stroke population.The Cochrane Library, MEDLINE, CINAHL, EMBASE, and PubMed were searched for up 15 January 2019. Three authors independently screened assessed methodological quality, using Assessment Multiple Systematic Reviews (AMSTAR) appraisal tool. Quality outcomes evaluated within was appraised with Grade Recommendation, Assessment, Development Evaluation (GRADE) tool.Twelve (n = 9,117 participants) rTMS on motor non-motor (aphasia, depression, dysphagia cognition) functions. The protocols applied measured diverse amongst selected reviews. findings suggest beneficial effect with: "moderate quality" hemineglect, "low moderate function (upper limb function, daily activities), aphasia post-stroke depression.Despite widespread use rTMS, high-quality its routine treatment survivors is lacking. Further studies are required establish differential roles various long-term effects population.
Language: Английский
Citations
46