Non-Invasive Brain Stimulation to Improve Functional Recovery and Predict Outcome After Intracerebral Hemorrhage: A Narrative Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 398 - 398

Published: Jan. 10, 2025

Intracerebral hemorrhage (ICH) is a leading cause of stroke-related mortality and long-term disability, with initial ICH volume, age, location the hemorrhage, clinical severity being key predictors outcome. While scores incorporating these elements are validated exhibit good inter-rater reliability, their accuracy in predicting recovery remains suboptimal. Non-invasive brain stimulation (NIBS) has emerged as potential adjunct for improving both prognostication functional survivors. Despite promising results, heterogeneity protocols, patients' populations, outcome measures have prevented NIBS implementation practice. This narrative review summarizes available evidence on association between NIBS, prediction recovery, discussing current challenges future perspectives.

Language: Английский

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The effects of combined high-frequency repetitive transcranial magnetic stimulation and cervical nerve root magnetic stimulation on upper extremity motor recovery following stroke

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Feb. 7, 2023

Upper limb motor impairments after stroke cause patients partial or total loss of the capability performing daily living, working, and social activities, which significantly affects quality life (QoL) brings a heavy burden to their families society. As non-invasive neuromodulation technique, transcranial magnetic stimulation (TMS) can act not only on cerebral cortex, but also peripheral nerves, nerve roots, muscle tissues. Previous studies have shown that cortex tissues has positive effect recovery upper function stroke, however, few reported combination two.This study was investigate whether high frequency repetitive (HF-rTMS) combined with cervical root more effectively ameliorates in patients. We hypothesized two achieve synergistic further promotes functional recovery.Sixty were randomly divided into four groups received real sham rTMS consecutively before other therapies, once over five fractions per week for 15 times. evaluated activities living at time pre-treatment, post-treatment, 3-month follow up.All completed procedures without any adverse effects. The improved each group treatment (post 1) 3 months 2). Combination better than single treatments alone sham.Both promoted stroke. protocol combining is beneficial improvement easily tolerate it.https://www.chictr.org.cn/, identifier ChiCTR2100048558.

Language: Английский

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Efficacy of repeated peripheral magnetic stimulation on upper limb motor function after stroke: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

Background Post-stroke patients with upper motor neuron lesions have limited function in the limbs, and spasticity occurs thus affecting functional recovery activities of daily living. Repetitive peripheral magnetic stimulation (rPMS) is a non-invasive treatment often used clinical rehabilitation. Recent studies shown that it can reduce improve patients. Objective This study aimed to evaluate effectiveness rPMS on limb stroke by meta-analysis. Materials methods Randomized controlled trials (RCTs) post-stroke were searched PubMed, Embase, Cochrane Library, Web Science, Clinical Trials. Databases from date creation 25 August 2024 evaluated using Collaboration tool. Methodological quality was assessed tools, meta-analyses performed RevMan (version 5.4) Stata 14.0). Results A total 8 included. RPMS improved patients’ FMA-UE scores compared controls (MD = 3.34, 95% CI [0.53, 6.15], p 0.02 < 0.05). also reduced −0.66, [−1.16, −0.15], 0.01 0.05) increased ability live independently 0.85, [0.19, 1.51], Subgroup analyses showed efficacy frequency ≤ 20 Hz better than > Hz; time 15–20 min more effective 30 min; application round coil other types coils. Conclusion The results suggest if patients, their may improve. However, number small, further research needed extend current analysis results. Systematic review registration https://www.crd.york.ac.uk/prospero/ , CRD42024584040.

Language: Английский

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Integrating Ultrasound-Guided Injections and Peripheral Magnetic Stimulation in Chronic Myofascial/Lumbar Pain

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 563 - 563

Published: March 31, 2025

Myofascial pain syndrome (MPS) is a common musculoskeletal disorder that significantly affects quality of life. Conventional treatment approaches include pharmacological interventions, physical therapy, and procedures such as dry needling. Among these, ultrasound-guided injections (USGIs) have gained recognition for their precision therapeutic benefits. Additionally, repetitive peripheral magnetic stimulation (rPMS) has emerged non-invasive neuromodulatory technique management. This perspective article examines the physiological mechanisms clinical applications USGIs rPMS, particularly in lumbar multifidus muscle, explores potential synergistic effects. MPS often associated with chronic muscle dysfunction due to energy depletion, leading persistent motor impairment. play crucial role restoring perfusion, disrupting cycles, providing diagnostic insights real time. In parallel, rPMS modulates neuromuscular activation, enhances endogenous control, promotes functional recovery. Ultrasound guidance effectiveness needling, interfascial plane blocks, fascial hydrodissection, while complements these strategies by facilitating reconditioning reducing via central mechanisms. The preliminary findings suggest combining results significant relief improvements patients low back pain. Integrating represents promising multimodal strategy managing MPS. By targeted neuromodulation, clinicians may optimize outcomes provide sustained Further research needed refine protocols assess long-term efficacy.

Language: Английский

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Effects of electrical and magnetic stimulation on upper extremity function after stroke: A systematic review and network meta‐analysis

PM&R, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Abstract Objectives To pool and rank the efficacy of various stimulation therapies, including repetitive peripheral magnetic (rPMS), neuromuscular electrical (NMES), functional (FES), transcranial (TMS), combinations these interventions on upper extremity function, activities daily living (ADL), spasticity after stroke relative to sham/conventional rehabilitation. Literature Survey MEDLINE, Scopus, Physiotherapy Evidence Database, Cochrane Central Register Controlled Clinical Trials, Google Scholar were searched from inception July 2022. Methodology Randomized controlled trials comparing any mentioned above (rPMS, NMES, FES, TMS, NMES+rPMS, NMES+TMS, FES+TMS, conventional rehabilitation) ADL, or five databases systematically reviewed collected. Two‐stage network meta‐analysis was applied. Synthesis Thirty‐four studies involving 1476 patients reporting function with Fugl‐Meyer Assessment pooled. NMES combined rPMS, FES showed significantly higher improvement than rehabilitation, pooled mean differences (95% confidence intervals) 14.69 (9.94–19.45), 9.09 (6.01–12.18), 6.10 (2.51–9.69), 4.07 (0.33–7.81), 3.61 (0.14–7.07) respectively. rPMS had highest probability for improving function. plus TMS but none significant in spasticity. Conclusions might be best intervention improve functions, most likely lead improved ADL quality evidence is low.

Language: Английский

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The effects of repetitive peripheral magnetic stimulation combined with repetitive transcranial magnetic stimulation on lower limb motor function and balance in patients with chronic stroke: A pilot randomized controlled trial

PM&R, Journal Year: 2025, Volume and Issue: unknown

Published: May 26, 2025

Abstract Background In the chronic phase of stroke, repetitive transcranial magnetic stimulation (rTMS) exhibits limited effectiveness in improving motor recovery due to reduced brain plasticity. Patients with stroke also typically present lower limb dysfunction and disability. Recent studies suggest that peripheral (rPMS) can promote plasticity potentially offer additional improvement patients stroke. Objective To investigate whether combining a designed rPMS program rTMS could further improve function, mobility, balance function Design Two‐arm randomized controlled trial. Setting Inpatient clinic. Participants 20 hemiparesis were recruited. Interventions One group received ipsilateral rTMS, other based on myofascial chain neural pathways. Main Outcome Measures The primary outcome measure was extremity section Fugl‐Meyer Assessment (FMA‐LE), evaluating function. Secondary outcomes included timed up go test (TUG), 10‐meter walking (10MWT), 6‐minute (6MWT), Berg scale (BBS), parameters measured by training evaluation system (Rx, mediolateral sway; Ry, anteroposterior RecArea, total sway area). All assessments conducted at baseline, 2 weeks post intervention, 4 intervention. Two‐way repeated measures analysis variance (ANOVA) then performed analyze any differences over time. Results ANOVA revealed significant interaction effect between time for FMA‐LE ( p = .001), 6MWT < TUG .015), BBS .046), Rx .008), Ry .009), RecArea .001). Effect size (the value partial ɳ ) 0.40. Conclusions This study provides evidence may be more practical approach ambulation, compared alone.

Language: Английский

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Traditional Chinese Medicine and Ferroptosis in Intracerebral Hemorrhage: A Potential Therapeutic Approach

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 4789 - 4808

Published: June 1, 2025

Language: Английский

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Effects of repetitive peripheral magnetic stimulation for the upper limb after stroke: Meta-analysis of randomized controlled trials

Heliyon, Journal Year: 2023, Volume and Issue: 9(5), P. e15767 - e15767

Published: April 23, 2023

IntroductionRepetitive peripheral magnetic stimulation (rPMS) can stimulate profound neuromuscular tissues painlessly to evoke action potentials in motor axons and induce muscle contraction for treating neurological conditions. It has been increasingly used stroke rehabilitation as an easy-to-administer approach therapeutic neuromodulation.ObjectiveWe performed this meta-analysis of randomized controlled trials systematically evaluate the effects rPMS upper limb patients with stroke, including impairment, spasticity, strength, activity limitation outcomes.MethodsThe was conducted following Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guideline. PubMed, EMBASE, Web Science, Cochrane Library, Physiotherapy Evidence Database (PEDro) were searched articles published before June 2022. Forest plots employed estimate pooled results included studies, I2 statistical analysis identify source heterogeneity. Publication bias examined by Egger's regression tests or visual inspection funnel plots.ResultsThe database searches yielded 1052 potential eligible literature; them, five met criteria, involving a total 188 participants. Patients group showed better improvement impairment measured FM-UE (MD: 5.39 [95% CI, 4.26 6.52]; P < 0.001; = 0%) compared control group. Among secondary outcomes, no difference found spasticity (SMD: 0.36 −0.05 0.77]; 0.08; 41%). There significant proximal 0.58 0.10 1.06]; 0.02; but not distal strength 1.18 −1.00 3.36]; 0.29; 93%). Moreover, outcomes significantly improved intervention 0.59 0.08 1.10]; 0%).ConclusionThis that might improve after stroke. Due limited number further clinical are still warranted more accurate interpretation recommendation.

Language: Английский

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Repetitive peripheral sensory stimulation for motor recovery after stroke: a scoping review

Topics in Stroke Rehabilitation, Journal Year: 2024, Volume and Issue: 31(7), P. 723 - 737

Published: March 7, 2024

Enhancing afferent information from the paretic limb can improve post-stroke motor recovery. However, uncertainties exist regarding varied sensory peripheral neuromodulation protocols and their specific impacts. This study outlines use of repetitive stimulation (RPSS) magnetic (rPMS) in individuals with stroke.

Language: Английский

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Application of peripheral magnetic stimulation in physiotherapeutic practice. (A literature review)

Problems of Balneology Physiotherapy and Exercise Therapy, Journal Year: 2024, Volume and Issue: 101(3), P. 62 - 62

Published: Jan. 1, 2024

Search and development of new physiotherapeutic technologies regenerative medicine for the treatment patients with different diseases is an urgent task modern medicine.

Language: Английский

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