Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model DOI Creative Commons
S. Oliver, Michael E. Williams, Mohit Kumar Jolly

et al.

npj Systems Biology and Applications, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 17, 2025

Abstract Epithelial-to-mesenchymal transition (EMT) plays a key role in the progression of cancer tumours, significantly reducing success treatment. EMT occurs when cell undergoes phenotypical changes, resulting enhanced drug resistance, higher plasticity, and increased metastatic abilities. Here, we employ 3D agent-based multiscale modelling framework using PhysiCell to explore over time two lines, OVCAR-3 SKOV-3. This approach allows us investigate spatiotemporal ovarian impacts conditions microenvironment. SKOV-3 lines possess highly contrasting tumour layouts, allowing wide range different dynamics morphologies be tested studied. Along with performing sensitivity analysis on model, simulation results capture biological observations trends seen growth development, thus helping obtain further insights into line dynamics.

Language: Английский

Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model DOI Creative Commons
S. Oliver, Michael E. Williams, Mohit Kumar Jolly

et al.

npj Systems Biology and Applications, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 17, 2025

Abstract Epithelial-to-mesenchymal transition (EMT) plays a key role in the progression of cancer tumours, significantly reducing success treatment. EMT occurs when cell undergoes phenotypical changes, resulting enhanced drug resistance, higher plasticity, and increased metastatic abilities. Here, we employ 3D agent-based multiscale modelling framework using PhysiCell to explore over time two lines, OVCAR-3 SKOV-3. This approach allows us investigate spatiotemporal ovarian impacts conditions microenvironment. SKOV-3 lines possess highly contrasting tumour layouts, allowing wide range different dynamics morphologies be tested studied. Along with performing sensitivity analysis on model, simulation results capture biological observations trends seen growth development, thus helping obtain further insights into line dynamics.

Language: Английский

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