Molecular Characterization of Zinc Transporter Proteins (ZnT) and the Roles in Diseases DOI Creative Commons

Yongyi Zhong

Highlights in Science Engineering and Technology, Journal Year: 2023, Volume and Issue: 74, P. 749 - 755

Published: Dec. 29, 2023

As an essential trace element, zinc is required by the human body, and it associated with various physiological activities. It can impact body development, brain function, bone growth, reproductive health immune function. Zinc deficiency cause many diseases, whereas excess lead to cytotoxicity as well. Thus, in significant sustain homeostasis. transporter protein (ZnT) reported take responsibility for transport from cytoplasm extracellular or organelle. includes nine family members, they are widely localized diverse tissues. Furthermore, some ZnTs function not only but also modulating Besides, shown be involved occurrence development of several including transient neonatal (TNZD), Parkinson’s disease (PD) others. This paper will review molecular characteristics their recent research progress on which may offer new insight into treatment.

Language: Английский

Regulation of Antigen‐Specific Immunotherapy with Nanomaterials DOI Creative Commons

Weifan Ye,

Yiwen Jia,

Hongze Ren

et al.

Advanced NanoBiomed Research, Journal Year: 2023, Volume and Issue: 3(12)

Published: Nov. 27, 2023

Nonspecific immunotherapies often induce general immune activation or suppression. Conversely, antigen‐specific immunotherapy, which refers to dampening augmenting adaptive immunity against a disease‐specific antigen, increases T‐cell target specificity pathological tissues, thereby reducing side effects on the rest of system. Advances in engineering strategies for nanomaterials have enabled feasible modulation their physicochemical features incorporate antigens and inherently interact with innate cells, remarkably amplifies orchestration responses cancer autoimmune diseases. From this contemporary perspective, basic principles immunotherapy are briefly introduced we elucidate how latest nanoengineering paradigms regulate functions heterogeneous subsets such as antigen‐presenting B regulatory cytotoxic T promoting treat diseases cancer. An outlook prospects remaining challenges been discussed for, translating scientific discoveries powerful into medical advances thus offering new treatment modalities patients unmet needs.

Language: Английский

Citations

0

Molecular Characterization of Zinc Transporter Proteins (ZnT) and the Roles in Diseases DOI Creative Commons

Yongyi Zhong

Highlights in Science Engineering and Technology, Journal Year: 2023, Volume and Issue: 74, P. 749 - 755

Published: Dec. 29, 2023

As an essential trace element, zinc is required by the human body, and it associated with various physiological activities. It can impact body development, brain function, bone growth, reproductive health immune function. Zinc deficiency cause many diseases, whereas excess lead to cytotoxicity as well. Thus, in significant sustain homeostasis. transporter protein (ZnT) reported take responsibility for transport from cytoplasm extracellular or organelle. includes nine family members, they are widely localized diverse tissues. Furthermore, some ZnTs function not only but also modulating Besides, shown be involved occurrence development of several including transient neonatal (TNZD), Parkinson’s disease (PD) others. This paper will review molecular characteristics their recent research progress on which may offer new insight into treatment.

Language: Английский

Citations

0