Development and evaluation of ibuprofen-loaded chitosan nanoparticles for pulmonary therapy DOI Creative Commons
Idais Rodríguez,

J. M. Mora-Muñoz,

Verónica Rico Pérez

et al.

Frontiers in Nanotechnology, Journal Year: 2024, Volume and Issue: 6

Published: Sept. 12, 2024

Lung injuries are increasingly prevalent due to various diseases causing alveolar damage, potentially leading respiratory disorders. This study employed an incubation method develop nano-encapsulated ibuprofen within a chitosan matrix for targeted pulmonary therapy. The encapsulation was successful without altering the molecular structure of chitosan, and 500 mg dose identified as optimal through lung tissue cell viability histological analysis. controlled release mechanism this formulation ensures delivery lungs, reducing inflammation promoting regeneration. approach highlights importance optimization presents promising strategy enhance efficacy safety treatments.

Language: Английский

The potential ameliorative role of Dimercaptosuccinic acid against the toxicity of Titanium Dioxide Nanoparticles on Caelatura nilotica clams DOI

Hoda H. Abdel‐Azeem,

Azza H. Mohamed,

Gamalat Y. Osman

et al.

Journal of Experimental Zoology Part A Ecological and Integrative Physiology, Journal Year: 2024, Volume and Issue: 341(9), P. 1053 - 1065

Published: July 21, 2024

Abstract The prevalent use of nanoparticles has adverse negative effects on biosystems. Subsequently, this study aimed to Caelatura nilotica assess the ecotoxicity TiO 2 NPs and how Dimercaptosuccinic acid (DMSA) improves these effects. Two concentrations (25 150 µg/L) were used for 28 days. bioaccumulation, gonadal weight, gonado‐somatic index, histopathological alterations gonads determined. tissues’ accumulation TiO2 was concentration‐time‐dependent: it 78.5 ± 28.93 μg/g dry weight in exposed clams µg/L after 4 weeks exposure. index significantly decreased group over experimental period that they ended with values (1.01 0.57 gm, 19.15 7.75%, respectively). There are some histological C. such as necrosis, deteriorated connective tissue, increased fibrous a reduced presence mature sperms ova, irregular shapes testicular/ovarian follicles. When using (DMSA), led reduction by end experiment. So, is promising model reflect nano‐toxics. DMSA emerges potentially valuable chelating agent abolishes nanoparticles.

Language: Английский

Citations

1
Development and evaluation of ibuprofen-loaded chitosan nanoparticles for pulmonary therapy DOI Creative Commons
Idais Rodríguez,

J. M. Mora-Muñoz,

Verónica Rico Pérez

et al.

Frontiers in Nanotechnology, Journal Year: 2024, Volume and Issue: 6

Published: Sept. 12, 2024

Lung injuries are increasingly prevalent due to various diseases causing alveolar damage, potentially leading respiratory disorders. This study employed an incubation method develop nano-encapsulated ibuprofen within a chitosan matrix for targeted pulmonary therapy. The encapsulation was successful without altering the molecular structure of chitosan, and 500 mg dose identified as optimal through lung tissue cell viability histological analysis. controlled release mechanism this formulation ensures delivery lungs, reducing inflammation promoting regeneration. approach highlights importance optimization presents promising strategy enhance efficacy safety treatments.

Language: Английский

Citations

0