Heavy metal(loid) bioaccumulation in fish and its implications for human health DOI Creative Commons
Dhary Alewy Almashhadany,

Rzgar Farooq Rashid,

K. I. Altaif‎

et al.

Italian Journal of Food Safety, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Heavy metal(loid)s (HM) pollution in aquatic environments is a serious issue due to the toxicity, persistence, bioaccumulation, and biomagnification of these pollutants. The main sources HM contamination are industrial activities, mining, agricultural practices, combustion fossil fuels. Fish can accumulate HMs through process called bioaccumulation. As larger predatory fish consume smaller fish, enter food chains become increasingly concentrated their tissues finally reach humans. Here, we provided general concise conclusion from current research findings on toxicological effects different body systems. Exposure lead range adverse health effects, including neurological damage, developmental disorders, kidney cardiovascular problems, cancers. Their long-term accumulation result chronic toxicity even at low levels exposure. exert cellular cytotoxicity by disrupting essential processes structures. They interfere with enzyme function, disrupt cell membrane integrity, induce oxidative stress, cause DNA ultimately leading death or dysfunction. Prevention control involve implementing measures reduce release into environment regulations processes, waste management, technologies. Additionally, monitoring remediation efforts crucial for identifying contaminated sites strategies such as soil water human exposure mitigate impact ecosystems. To conclude, poses risks public environment, necessitating urgent interdisciplinary harmful promote sustainable practices that flow biological

Language: Английский

Public health concerns of multifaceted exposures to metal and metalloid mixtures: a systematic review DOI
Godswill J. Udom,

David Iyaye,

Benjamin Oritsemuelebi

et al.

Environmental Monitoring and Assessment, Journal Year: 2025, Volume and Issue: 197(5)

Published: April 2, 2025

Language: Английский

Citations

1
The mediating role of inflammatory biomarkers in the association between serum copper and sarcopenia DOI Creative Commons

Dapeng Zeng,

Bo Chen, Hao Wang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 11, 2025

This study aims to investigate the association between serum copper (Cu), selenium (Se), zinc (Zn), Se/Cu and Zn/Cu ratios risk of sarcopenia. In this study, which involved 2766 adults aged ≥ 20 years enrolled in National Health Nutrition Examination Survey (NHANES) from 2011 2016, multivariable logistic regression, restricted cubic spline (RCS) models mediation analyses were used. After full adjustment, regression revealed that higher levels correlated with an increased Conversely, (OR 0.45, 95% CI 0.23-0.89, P = 0.023) 0.49, 0.27-0.90, 0.024) associated a decreased The RCS curve indicated non-linear, roughly inverted L-shaped relationship Cu sarcopenia (P non-linear < 0.001). Additionally, 0.179) 0.786) showed negative linear associations risk. Furthermore, white blood cell (WBC) count, neutrophil systemic inflammation index (SII) identified as significant mediators sarcopenia, proportions 6.34%, 6.20%, 4.37%, respectively (all 0.05). Therefore, balancing essential trace metals is crucial for maintaining muscle health.

Language: Английский

Citations

0
Association Between Urinary Metal Levels and Chronic Kidney Dysfunction in Rural China: A Study on Sex-Specific Differences DOI Creative Commons

K Teng,

Qinyi Guan, Qiumei Liu

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(1), P. 55 - 55

Published: Jan. 14, 2025

Background: While current epidemiological studies have documented associations between environmental metals and renal dysfunction, the majority concentrated on plasma metal levels. The relationship urinary exposure chronic kidney disease (CKD) remains contentious, particularly within specific demographic groups. Methods: This cross-sectional study included 2919 rural Chinese adults recruited 2018 2019. Urine were measured by ICP-MS. Least absolute shrinkage selection operator (LASSO) regression was employed to identify significantly associated with CKD. Then, we used binary logistic regression, along restricted cubic spline (RCS) models, assess individual effects of Quantile g-computation, weighted quantile sum Bayesian kernel machine (BKMR) models applied evaluate combined exposures Gender-stratified analyses also conducted explore these associations. Results: LASSO identified seven (V, Cu, Rb, Sr, Ba, W, Pb) significant impacts In single-metal Cu W exhibited a positive correlation CKD, whereas V, Pb showed negative correlations (all p < 0.05). RCS analysis revealed nonlinear Pb, CKD p-nonlinear multi-metal model, quantile-based g-computation demonstrated collective association risk for mixed (OR (95% CI) = −0.430 (−0.656, −0.204); 0.001), contributing this effect. WQS model further confirmed joint CI): −0.885 (−1.083, −0.899); V as main contributor. BKMR indicated an overall impact mixture risk. Interactions may exist well Sr Pb. female subgroup in consistency association. Conclusions: Our findings demonstrate risk, notable females. Joint multiple involve synergistic or antagonistic interactions influencing function. Further research is needed validate observations elucidate underlying mechanisms.

Language: Английский

Citations

0
Cadmium Exposure and Health Outcomes:An Umbrella Review of Meta-analyses DOI

Wenzhuo Xu,

Sainan Wang, Wen-hua Ruan

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121547 - 121547

Published: April 1, 2025

Language: Английский

Citations

0
The association between urinary cadmium exposure levels and overactive bladder syndrome in the U.S. adults from NHANES database DOI Creative Commons
Kaixuan Zhang,

Yanghao Tai,

Yu Gong

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 15, 2025

The relationship between urinary cadmium exposure levels and overactive bladder (OAB) has not been fully elucidated. purpose of this study was to further investigate the correlation OAB risk in adults. Laboratory data on were obtained from National Health Nutrition Examination Survey (NHANES) database for period 2007-2016. defined as Overactive Bladder Syndrome Symptom Score (OABSS, score ≥ 3) according International Continence Society. We used weighted logistic regression modelling assess association OAB. reliability findings assessed using restricted cubic spline, subgroup analysis. A total 7225 individuals included study, with a prevalence 18.6%. Higher U-Cd associated an increased syndrome. In models 1 unadjusted variables (OR = 1.904; 95% CI 1.902-1.905, p < 0.001), model 2 partially adjusted OR 1.264; 1.263-1.265, 0.001) 3 1.232; 1.230-1.230, which significant. This remained stable across subgroups sex, age, PIR, BMI. Restricted spline showed linear (p nonlinear > 0.05). Urinary are positively developing US adult population, but studies needed elucidate causal

Language: Английский

Citations

0
Analysis of relationship between mixed heavy metal exposure and early renal damage based on a weighted quantile sum regression and Bayesian kernel machine regression model DOI

Qi An,

Qingyao Wang,

Rujie Liu

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 84, P. 127438 - 127438

Published: March 19, 2024

Language: Английский

Citations

1
Investigating the relationship of co-exposure to multiple metals with kidney toxicity: An integrated perspective from epidemiology and adverse outcome pathways DOI

Yican Wang,

Mengyun Qiao,

Haitao Yang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135844 - 135844

Published: Sept. 16, 2024

Language: Английский

Citations

1
Heavy metal(loid) bioaccumulation in fish and its implications for human health DOI Creative Commons
Dhary Alewy Almashhadany,

Rzgar Farooq Rashid,

K. I. Altaif‎

et al.

Italian Journal of Food Safety, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Heavy metal(loid)s (HM) pollution in aquatic environments is a serious issue due to the toxicity, persistence, bioaccumulation, and biomagnification of these pollutants. The main sources HM contamination are industrial activities, mining, agricultural practices, combustion fossil fuels. Fish can accumulate HMs through process called bioaccumulation. As larger predatory fish consume smaller fish, enter food chains become increasingly concentrated their tissues finally reach humans. Here, we provided general concise conclusion from current research findings on toxicological effects different body systems. Exposure lead range adverse health effects, including neurological damage, developmental disorders, kidney cardiovascular problems, cancers. Their long-term accumulation result chronic toxicity even at low levels exposure. exert cellular cytotoxicity by disrupting essential processes structures. They interfere with enzyme function, disrupt cell membrane integrity, induce oxidative stress, cause DNA ultimately leading death or dysfunction. Prevention control involve implementing measures reduce release into environment regulations processes, waste management, technologies. Additionally, monitoring remediation efforts crucial for identifying contaminated sites strategies such as soil water human exposure mitigate impact ecosystems. To conclude, poses risks public environment, necessitating urgent interdisciplinary harmful promote sustainable practices that flow biological

Language: Английский

Citations

0