Circulating micronutrients levels and their association with the risk of endometriosis DOI Creative Commons

Yanna Zhang,

Meng Li,

Feifei Zhang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 16, 2024

Background Endometriosis, a prevalent gynecological disease, has an unclear pathogenesis. Micronutrients play crucial role in disease development, which led to investigation of their association with endometriosis. Methods In this study, we analyzed the relationship between 15 micronutrients and endometriosis using both univariate multivariate Mendelian randomization (MR) assess correlation. The results were validated high-performance liquid chromatography (HPLC). Results MR analysis indicated that vitamin B6 (OR = 1.7060, 95% CI: 1.1796–2.4672, p 0.0045) calcium 1.4834, 1.0747–2.0475, 0.0165) are associated increased risk Higher intakes greater likelihood developing Egger regression’s intercept term demonstrated no evidence pleiotropy ( > 0.05) or heterogeneity (p SNPs for B6. analysis, 2.397, 1.231–4.669, 0.01) was linked endometriosis, independently other exposure factors. No significant 0.831) 0.369) observed genetic variation affirming reliability analysis. HPLC confirmed increase serum levels calcium, aligning findings. Conclusion Vitamin may be potentially acting as independent factor. Further research is essential elucidate offering novel insights prevention treatment strategies.

Language: Английский

The Mechanism by Which Estrogen Level Affects Knee Osteoarthritis Pain in Perimenopause and Non-Pharmacological Measures DOI Open Access
Huiying Zhao,

Yu Fan,

Wei Wu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2391 - 2391

Published: March 7, 2025

Perimenopausal women have fluctuating estrogen levels, which often trigger a range of symptoms perimenopausal syndromes as levels decrease. Changes in are closely related to pain knee osteoarthritis (KOA), has long been research area great interest women. In recent years, it found that an important role KOA pain, namely, can affect through the regulation inflammatory responses, inhibition cellular senescence and apoptosis, modulation neurotransmitters, may provide new ideas for treatment. This study aims describe mechanism level on perimenopause non-pharmacological measures, such physical therapy, factor traditional Chinese medicine, diet, reference treatment with KOA.

Language: Английский

Citations

0
Serum copper to zinc ratio and risk of endometriosis: Insights from a case–control study in infertile patients DOI Creative Commons
Yanping Liu,

Guihong Cheng,

Hong Li

et al.

Reproductive Medicine and Biology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 1, 2025

Endometriosis is a prevalent gynecological disorder, yet data on the role of trace metal elements in its risk remain limited. We aimed to investigate relationship between serum copper (Cu), zinc (Zn), iron (Fe), magnesium (Mg) levels, and Cu/Zn ratio with endometriosis. This study involved 568 infertile patients diagnosed endometriosis, compared 819 without endometriosis (Control group). Basic characteristics, hormonal parameters, essential were measured analyzed. The findings indicated notable decrease Zn levels group controls, alongside significant increase (p < 0.001). Restricted cubic spline (RCS) analysis revealed linear risk. Moreover, exhibited negative correlation trend = 0.005), while displayed positive risk, even after adjusting for age, body mass index (BMI), baseline hormones Compared first quartile adjustment, odds ratios (ORs) 95% confidence intervals (CIs) second fourth quartiles 1.97 (1.37, 2.83) 2.63 (1.80, 3.84), respectively. provided evidence decreased an increased being associated elevated among patients. These offer valuable real-world data, enriching our understanding

Language: Английский

Citations

0
Qiju Dihuang Pill protects the lens epithelial cells via alleviating cuproptosis in diabetic cataract DOI
Jun Yang, Yichen Gao,

Han Mao

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118444 - 118444

Published: June 6, 2024

Language: Английский

Citations

3
Serum Copper to Zinc Ratio and Risk of Endometriosis: Insights from a Case-Control Study DOI Creative Commons
Yanping Liu,

Guihong Cheng,

Hong Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 20, 2024

Abstract The significance of trace metal elements in the development endometriosis has garnered increasing interest. We aimed to investigate relationship between serum copper (Cu), zinc (Zn), iron (Fe), magnesium (Mg) levels, and Cu/Zn ratio with risk endometriosis. This study involved 568 infertile patients diagnosed endometriosis, compared 819 without (Control group). Basic characteristics, hormonal parameters, essential were measured analyzed. findings indicated a notable decrease Zn levels group controls, alongside significant increase (P < 0.001). Restricted cubic spline analysis (RCS) revealed linear Moreover, exhibited negative correlation trend = 0.005), while displayed positive risk, even after adjusting for age, body mass index (BMI), baseline hormones Compared first quartile adjustment, odds ratios (ORs) 95% confidence intervals (CIs) second fourth quartiles 1.97 (1.37, 2.83) 2.63 (1.80, 3.84), respectively. provided evidence decreased increased being associated an elevated among patients.

Language: Английский

Citations

0
Circulating micronutrients levels and their association with the risk of endometriosis DOI Creative Commons

Yanna Zhang,

Meng Li,

Feifei Zhang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 16, 2024

Background Endometriosis, a prevalent gynecological disease, has an unclear pathogenesis. Micronutrients play crucial role in disease development, which led to investigation of their association with endometriosis. Methods In this study, we analyzed the relationship between 15 micronutrients and endometriosis using both univariate multivariate Mendelian randomization (MR) assess correlation. The results were validated high-performance liquid chromatography (HPLC). Results MR analysis indicated that vitamin B6 (OR = 1.7060, 95% CI: 1.1796–2.4672, p 0.0045) calcium 1.4834, 1.0747–2.0475, 0.0165) are associated increased risk Higher intakes greater likelihood developing Egger regression’s intercept term demonstrated no evidence pleiotropy ( &gt; 0.05) or heterogeneity (p SNPs for B6. analysis, 2.397, 1.231–4.669, 0.01) was linked endometriosis, independently other exposure factors. No significant 0.831) 0.369) observed genetic variation affirming reliability analysis. HPLC confirmed increase serum levels calcium, aligning findings. Conclusion Vitamin may be potentially acting as independent factor. Further research is essential elucidate offering novel insights prevention treatment strategies.

Language: Английский

Citations

0