The Regulation of Trace Metal Elements in Cancer Ferroptosis DOI Creative Commons

Xiaoyan Wang,

Yuanyuan Xue, Lei Chang

et al.

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.

Language: Английский

Endoplasmic reticulum stress-autophagy axis is involved in copper-induced ovarian ferroptosis DOI
Tingting Wang,

Qianzhuo Liu,

Limin Wu

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
A dynamic study on serum biomarkers and kidney injury in a gosling model of hyperuricemia DOI Creative Commons

Yuanjing Chen,

Yang Haiming,

Zhiyue Wang

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105144 - 105144

Published: April 1, 2025

Hyperuricemia, a metabolic disorder characterized by elevated serum uric acid levels, poses significant challenges to poultry health and productivity. This study aimed establish hyperuricemia model in goslings through multi-factorial induction approach using high-purine, high-protein, high-calcium diet, investigate its dynamic progression, serological markers, renal pathology. A total of 160 male Sanhua were randomly assigned control groups fed either basal diet or for 18 days. Key findings revealed elevations acid, creatinine, urea nitrogen levels the group from day 5 onward, peaking on 13 (p < 0.01). Activities xanthine oxidase adenosine deaminase consistently higher group, indicating enhanced purine metabolism oxidative stress. Histopathological analysis showed progressive damage, including tubular degeneration, interstitial fibrosis, glomerular injury, becoming evident 7 severe 13. Ultrastructural examination further mitochondrial dysfunction, podocyte effacement, basement membrane disruption group. Behavioral abnormalities, such as reduced mobility "shrinking neck" phenomenon, observed 9, reflecting systemic disease severity. The expression fibrosis-related Col-1, Col-3, α-SMA, demonstrated progression fibrosis extracellular matrix remodeling. These identify biomarkers suggest potential therapeutic targets. establishes comprehensive framework understanding hyperuricemia-associated pathology lays groundwork developing strategies mitigate impact

Language: Английский

Citations

0
The Regulation of Trace Metal Elements in Cancer Ferroptosis DOI Creative Commons

Xiaoyan Wang,

Yuanyuan Xue, Lei Chang

et al.

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.

Language: Английский

Citations

0