Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial DOI Open Access

Matthew Charles Bomar,

Taylor Russell Ewell,

Reagan L. Brown

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 915 - 915

Published: March 6, 2025

Background/Objectives: Although the importance of magnesium for overall health and physiological function is well established, its influence on exercise performance less clear. The primary study objective was to determine short-term supplementation cycle ergometer performance. hypothesis that would elicit an ergogenic effect. Methods: A randomized, double-blind, placebo-controlled, two-period crossover design used men women who were regular exercisers. Fifteen participants ingested either a placebo or chloride (MgCl2 300 mg) twice per day, 9 days, separated by 3-week washout. During days 8 9, completed battery tests, whole blood, vastus lateralis, stools sampled. outcomes maximal oxygen uptake (VO2max), simulated 10 km time trial, sprint Additional included skeletal muscle mitochondrial respiration, and, account known laxative effects magnesium, gut microbiota diversity. Results: Compared with placebo, MgCl2 increased circulating ionized Mg concentration (p < 0.03), decreased VO2max (44.4 ± 7.7 vs. 41.3 8.0 mL/kg/min; p = 0.005), mean power output during 30 s (439 88 415 W; 0.03). trial unaffected (1282 126 1281 97 s; 0.89). In muscle, respiration in presence fatty acids at complex II 0.04). There no significant impacts richness (CHAO1; 0.68), Shannon's Diversity 0.23), beta-diversity (Bray-Curtis distances; 0.74). Conclusions: summary, had modest ergolytic respiration. We recommend exercisers, free from hypomagnesemia, should not supplement their diet magnesium.

Language: Английский

Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial DOI Open Access

Matthew Charles Bomar,

Taylor Russell Ewell,

Reagan L. Brown

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 915 - 915

Published: March 6, 2025

Background/Objectives: Although the importance of magnesium for overall health and physiological function is well established, its influence on exercise performance less clear. The primary study objective was to determine short-term supplementation cycle ergometer performance. hypothesis that would elicit an ergogenic effect. Methods: A randomized, double-blind, placebo-controlled, two-period crossover design used men women who were regular exercisers. Fifteen participants ingested either a placebo or chloride (MgCl2 300 mg) twice per day, 9 days, separated by 3-week washout. During days 8 9, completed battery tests, whole blood, vastus lateralis, stools sampled. outcomes maximal oxygen uptake (VO2max), simulated 10 km time trial, sprint Additional included skeletal muscle mitochondrial respiration, and, account known laxative effects magnesium, gut microbiota diversity. Results: Compared with placebo, MgCl2 increased circulating ionized Mg concentration (p < 0.03), decreased VO2max (44.4 ± 7.7 vs. 41.3 8.0 mL/kg/min; p = 0.005), mean power output during 30 s (439 88 415 W; 0.03). trial unaffected (1282 126 1281 97 s; 0.89). In muscle, respiration in presence fatty acids at complex II 0.04). There no significant impacts richness (CHAO1; 0.68), Shannon's Diversity 0.23), beta-diversity (Bray-Curtis distances; 0.74). Conclusions: summary, had modest ergolytic respiration. We recommend exercisers, free from hypomagnesemia, should not supplement their diet magnesium.

Language: Английский

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