Ophthalmology and Therapy,
Journal Year:
2024,
Volume and Issue:
13(12), P. 3203 - 3213
Published: Nov. 1, 2024
Dry
eye
disease
(DED)
is
a
multifactorial
condition
of
the
ocular
surface
(OS)
characterized
by
loss
tear
film
homeostasis,
discomfort,
and
vision
disturbances.
Most
available
lubricants
target
aqueous
deficiency
tear,
restoring
only
this
layer,
leaving
lipid
stratum
deficient,
as
occurs
in
most
patients
with
evaporative
DED.
An
innovative
propylene
glycol-hydroxypropyl
guar
enriched
phospholipid
nanoemulsion
(PG-HPG-PH-N)
indicated
to
restore
deficiencies
both
layers
film,
its
composition
was
designed
increase
lubricant
retention
on
OS.
The
purpose
study
evaluate,
through
Ocular
Surface
Disease
Index
(OSDI)
clinical
assessment,
treatment
who
had
DED
due
arising
from
mixed
or
subtypes
PG-HPG-PH-N
at
reduced
frequency
twice
day,
prospective,
multicenter,
single-arm
study.
Patients
were
screened
days
−
7
0,
day
1
(baseline
first
treatment)
28
lubricant.
After
visit
(screening
visit,
0),
pre-treatment
OS
returned
their
research
center
14
for
complete
including
anamnesis,
OSDI,
corrected
visual
acuity,
breakup
time
(TFBUT),
staining
evaluation,
tolerability
index,
environmental
exposure
questionnaire.
Seventy
enrolled
(60
women,
10
men),
mean
age
45
(range
27–64)
years.
TFBUT
results
showed
an
improvement
stability
vital
dyes
sodium
fluorescein
lysamine
green
decrease
corneal
after
treatment.
No
significant
adverse
events
reported,
demonstrating
good
can
be
considered
safe
effective
treating
deficiency,
subtypes.
Brazilian
National
Research
Ethics
Commission
(ReBEC
registration
number
16055).
Medicina,
Journal Year:
2024,
Volume and Issue:
60(9), P. 1458 - 1458
Published: Sept. 5, 2024
Dry
eye
disease
is
a
multifactorial
condition
characterised
by
tear
film
instability,
hyperosmolarity
and
ocular
surface
inflammation.
Understanding
the
epidemiology
of
dry
recognising
both
modifiable
non-modifiable
risk
factors
can
assist
care
practitioners
in
assessing,
treating,
managing
patients
with
condition.
This
review
considers
current
knowledge
surrounding
its
incidence
prevalence,
as
well
associated
demographic,
systemic,
ocular,
iatrogenic,
lifestyle-related
factors.
Population-based
prevalence
estimates
vary
according
to
diagnostic
criteria
used
define
disease,
severity
demographic
characteristics
population.
Considering
recent
data
variable
population
demographics,
conservative
suggest
that
10-20%
over
40
years
age
report
moderate
severe
symptoms
and/or
seek
treatment
for
disease.
Individuals
specific
may
be
at
increased
developing
Advanced
age,
female
sex
East
Asian
ethnicity
have
been
identified
key
features
predisposing
individuals
Systemic
conditions
an
include
migraine,
Sjögren
syndrome,
connective
tissue
disorders,
mental
health
diabetes
mellitus
androgen
deficiency.
Medications
contribute
this
antidepressants,
antihistamines,
hormone
replacement
therapy.
Ocular
iatrogenic
blepharitis,
Translational Vision Science & Technology,
Journal Year:
2024,
Volume and Issue:
13(5), P. 13 - 13
Published: May 20, 2024
The
purpose
of
this
study
was
to
conduct
a
large-scale
genome-wide
association
(GWAS)
and
construct
polygenic
risk
score
(PRS)
for
stratification
in
patients
with
dry
eye
disease
(DED)
using
the
Taiwan
Biobank
(TWB)
databases.
Vision,
Journal Year:
2025,
Volume and Issue:
9(2), P. 27 - 27
Published: April 1, 2025
Discomfort
is
one
of
the
leading
causes
associated
with
contact
lens
dropout.
This
study
investigated
changes
in
tear
film
parameters
induced
by
wear
and
their
relationship
ocular
symptomology.
Thirty-four
wearers
(32.9
±
9.1
years,
7
men)
thirty-three
non-lens
(29.4
6.8
12
participated
this
clinical
setting.
Subjects
were
categorised
into
asymptomatic
(n
=
11),
moderate
15),
or
severe
symptomatic
8).
Clinical
evaluations
performed
morning,
including
blink
frequency
completeness,
pre-corneal
(NIBUT)
pre-lens
non-invasive
break-up
(PL-NIBUT),
lipid
interference
patterns,
meniscus
height.
Contact
had
a
higher
percentage
incomplete
blinks
(37%
vs.
19%,
p
<
0.001)
reduced
height
compared
to
controls
(0.24
0.08
0.28
0.10
mm,
0.014).
PL-NIBUT
was
shorter
than
NIBUT
(7.6
6.2
10.7
9.3
s.
0.002).
Significant
statistical
differences
between
groups
found
(p
0.01)
0.05),
recording
times
symptomatic.
Long-term
use
silicone–hydrogel
lenses
can
affect
stability,
production,
adequate
distribution
through
blinking.
Ocular
symptomology
correlates
stability
both
non-wearers.
Nanomaterials,
Journal Year:
2025,
Volume and Issue:
15(7), P. 552 - 552
Published: April 4, 2025
The
tear
film,
consisting
of
the
aqueous
and
lipid
layers,
maintains
homeostasis
ocular
surface;
therefore,
when
disturbed,
it
can
cause
dry
eye,
which
affects
millions
people
worldwide.
Understanding
dynamics
film
layers
is
essential
for
developing
efficient
drug
delivery
systems
eye
disease.
Quantum
dots
(QDs)
offer
potential
real-time
monitoring
evaluating
its
dynamics.
Hydrophilic
silicon
QDs
(Si-QDs)
have
already
been
optimised
to
image
layer
film.
This
study
was
conducted
optimise
hydrophobic
Si-QDs
were
synthesised
in
solution
characterised
by
transmission
electron
microscope
spectrofluorophotometry.
fluorescence
emission
monitored
vitro
mixed
with
artificial
tears.
cytotoxicity
assessed
cultured
human
corneal
epithelial
cells
using
an
MTT
assay
following
24
h
exposure.
2.65
±
0.35
nm
size
non-toxic
at
<16
µg/mL.
emitted
stable
green
20
min
but
demonstrated
aggregation
higher
concentrations.
These
findings
highlight
as
a
biomarker
imaging
layer.
However,
further
research
on
surface
functionalisation
preclinical
evaluations
are
recommended
enhanced
solubility
biocompatibility
surface.
