Phospholipid Nanoemulsion-Based Ocular Lubricant for the Treatment of Dry Eye Subtypes: A Multicenter and Prospective Study DOI Creative Commons

Maria Cristina Nishiwaki-Dantas,

Denise de Freitas,

Denise Oliveira Fornazari

et al.

Ophthalmology and Therapy, Journal Year: 2024, Volume and Issue: 13(12), P. 3203 - 3213

Published: Nov. 1, 2024

Dry eye disease (DED) is a multifactorial condition of the ocular surface (OS) characterized by loss tear film homeostasis, discomfort, and vision disturbances. Most available lubricants target aqueous deficiency tear, restoring only this layer, leaving lipid stratum deficient, as occurs in most patients with evaporative DED. An innovative propylene glycol-hydroxypropyl guar enriched phospholipid nanoemulsion (PG-HPG-PH-N) indicated to restore deficiencies both layers film, its composition was designed increase lubricant retention on OS. The purpose study evaluate, through Ocular Surface Disease Index (OSDI) clinical assessment, treatment who had DED due arising from mixed or subtypes PG-HPG-PH-N at reduced frequency twice day, prospective, multicenter, single-arm study. Patients were screened days − 7 0, day 1 (baseline first treatment) 28 lubricant. After visit (screening visit, 0), pre-treatment OS returned their research center 14 for complete including anamnesis, OSDI, corrected visual acuity, breakup time (TFBUT), staining evaluation, tolerability index, environmental exposure questionnaire. Seventy enrolled (60 women, 10 men), mean age 45 (range 27–64) years. TFBUT results showed an improvement stability vital dyes sodium fluorescein lysamine green decrease corneal after treatment. No significant adverse events reported, demonstrating good can be considered safe effective treating deficiency, subtypes. Brazilian National Research Ethics Commission (ReBEC registration number 16055).

Language: Английский

Low Expression of Vitamin D Receptor in Patients With Dry Eye Disease DOI
Antonia Vieira,

Javiera Meza,

Rodolfo Garretón

et al.

Cornea, Journal Year: 2024, Volume and Issue: 43(12), P. 1542 - 1546

Published: May 14, 2024

This study aimed to compare the expression of vitamin D receptor (VDR) on ocular surface patients with dry eye disease (DED) and controls without ophthalmological pathologies.

Language: Английский

Citations

0
Beauty versus Health—How Eyelash Extensions May Affect Dry Eye Disease? DOI Open Access
Christina N Grupcheva,

Dimitar Grupchev,

Natalya Usheva

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(11), P. 3101 - 3101

Published: May 25, 2024

Background: Eyelash extensions (EEs) are among the most popular cosmetic procedures today. There is no prospective study demonstrating how this procedure affects ocular surface and eye dryness in particular. The goal of to evaluate effect EEs removal on dry symptoms signs. Materials Methods: subjects were prospectively recruited from routine clinical examinations for complaints. Only with an OSDI score above 31 included study. also planned have removed agreed abstain makeup use new 4 weeks. presence was evaluated by questionnaire, objectively tear breakup time (TBUT), staining (Oxford scale) blinking intervals. All tests performed at baseline weeks after removal. Results: mean age our patients, all female, 28 years. size type diverse. decision process mainly based appearance models. None had any health conditions. result questionnaire 33.4 improved 26.7 points Objectively, TBUT increased 11.25 13.96 s. For same period, blinks two per minute, reduced 1.0 grade. Conclusions: Removal improves objective signs eye. beauty regarding eyelashes might not be innocuous health.

Language: Английский

Citations

0
Disease and Health Care Burden of Ocular Pain DOI
Barry Power, J. Brodie, Michael T. Wang

et al.

JAMA Ophthalmology, Journal Year: 2024, Volume and Issue: 142(7), P. 660 - 660

Published: June 6, 2024

Our website uses cookies to enhance your experience. By continuing use our site, or clicking "Continue," you are agreeing Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Journals Network Open Cardiology Dermatology Health Forum Internal Medicine Neurology Oncology Otolaryngology–Head & Neck Surgery Pediatrics Psychiatry Archives of (1919-1959) JN Learning / CMESubscribeJobsInstitutions LibrariansReprints Permissions Terms Use Privacy Accessibility Statement 2024 American Medical Association. All Rights Reserved Search Archive Input Term Sign In Individual inCreate an Account Access through institution Purchase Options: Buy this article Rent Subscribe the journal

Language: Английский

Citations

0
Safety and Efficacy of Photocatalytic Micro-Mist Desktop Humidifier for Dry Eye Caused by Digital Environment: A Randomized Controlled Trial DOI Open Access
Reiko Arita, Shima Fukuoka

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(13), P. 3720 - 3720

Published: June 26, 2024

Background/Objectives: Modern life is inconceivable without visual display terminal (VDT) work, including smartphones, computers, and games for both children adults. VDT work under air conditioning low humidity poses a high risk of dry eye digital strain. Methods: Thirty-one participants were randomly divided into two groups using desktop humidifier with photocatalytic technology, namely the "with mist" (humidifier) group "without (control) group. Participants performed tasks or mist 1 h. Ocular subjective symptoms objective tear film parameters assessed before, immediately after, 1.5 h after task mist. (Registry ID: UMIN000054379) Results: symptom scores improved significantly in up to later compared before (p < 0.001, =0.006, respectively). Immediately task, meniscus height was higher non-invasive breakup time longer than control =0.040, Plugging meibomian gland orifices reduced only remained = 0.004, 0.016, Conclusions: The use during resulted significant improvements symptoms. could be effective alleviating strain computer users modern office environment.

Language: Английский

Citations

0
Phospholipid Nanoemulsion-Based Ocular Lubricant for the Treatment of Dry Eye Subtypes: A Multicenter and Prospective Study DOI Creative Commons

Maria Cristina Nishiwaki-Dantas,

Denise de Freitas,

Denise Oliveira Fornazari

et al.

Ophthalmology and Therapy, Journal Year: 2024, Volume and Issue: 13(12), P. 3203 - 3213

Published: Nov. 1, 2024

Dry eye disease (DED) is a multifactorial condition of the ocular surface (OS) characterized by loss tear film homeostasis, discomfort, and vision disturbances. Most available lubricants target aqueous deficiency tear, restoring only this layer, leaving lipid stratum deficient, as occurs in most patients with evaporative DED. An innovative propylene glycol-hydroxypropyl guar enriched phospholipid nanoemulsion (PG-HPG-PH-N) indicated to restore deficiencies both layers film, its composition was designed increase lubricant retention on OS. The purpose study evaluate, through Ocular Surface Disease Index (OSDI) clinical assessment, treatment who had DED due arising from mixed or subtypes PG-HPG-PH-N at reduced frequency twice day, prospective, multicenter, single-arm study. Patients were screened days − 7 0, day 1 (baseline first treatment) 28 lubricant. After visit (screening visit, 0), pre-treatment OS returned their research center 14 for complete including anamnesis, OSDI, corrected visual acuity, breakup time (TFBUT), staining evaluation, tolerability index, environmental exposure questionnaire. Seventy enrolled (60 women, 10 men), mean age 45 (range 27–64) years. TFBUT results showed an improvement stability vital dyes sodium fluorescein lysamine green decrease corneal after treatment. No significant adverse events reported, demonstrating good can be considered safe effective treating deficiency, subtypes. Brazilian National Research Ethics Commission (ReBEC registration number 16055).

Language: Английский

Citations

0