Absorption of Toxicants from the Ocular Surface: Potential Applications in Toxicology

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 645 - 645

Published: March 6, 2025

In relation to the eye, body can absorb substances from ocular surface fluid (OSF) in a few ways: directly through conjunctival sac, nasal mucosa as drains into nose, or ingestion. Regardless of absorption method, sac should be used toxicological matrix, even though only small quantities are needed. Contemporary analytical techniques make it suitable matrix for research. Analyzing and nano-quantities analyte requires high-cost, sophisticated tools, which is particularly relevant high-throughput environment new drug cosmetics testing. Environmental toxicology also presents challenge, many pollutants enter system using same route. A review existing literature was conducted assess potential applications clinical forensic related toxicants surface. The selection studies this aimed identify new, more efficient, cost-effective technology diagnostic methods.

Language: Английский

Delivery of Itgb1-siRNA by triptolide-modified and anti-Flt1 peptide-guided ionizable cationic LNPs for targeted therapy of corneal neovascularization

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 383, P. 113811 - 113811

Published: May 3, 2025

Language: Английский